Simple view

Full metadata view

Authors

Statistics

Reversed-phase TLC study of some long chain arylpiperazine of imidazolidine-2,4-dione and imidazo[2,1-φ]purine-2,4-dione derivatives

2014
journal article
article
Journal
Acta Poloniae Pharmaceutica. Drug Research
Author
Zagórska Agnieszka

Czopek Anna

Pełka Karolina

Stanisz-Wallis Krystyna

Pawłowski Maciej
Volume
71
Number
3
Pages
379-383
ISSN
0001-6837
eISSN
2353-5288
Keywords in English

imidazolidine-2,4-diones

imidazo[2,1-f]purine-2,4-diones

lipophilicity

URL
http://www.ptfarm.pl/pub/File/Acta_Poloniae/2014/3/379.pdf
Access date
2016-10-03
Remarks

Bibliogr. s. 383

Language
English
Journal language
English
Abstract in English

The chromatographic parameters of arylpiperazinylpropyl derivatives of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione were investigated using reversed-phase thin layer chromatography method. The results revealed that RM0 of investigated compounds depended on substituent in arylpiperazinyl fragment as well as on a nature of (cycloalkyl)aromatic ring at 5 position of imidazolidine-2,4-dione and at 7 position of imidazo[2,1-f]theophylline. The RM0 parameters were compared with computationally calculated partition coefficients values by principal component analysis (PCA). To verify the influence of lipophilic parameter of investigated compounds on their biological activity the statistical analysis of Mann-Whitney was performed.

Affiliation
Wydział Farmaceutyczny : Zakład Chemii LekówWydział Farmaceutyczny : Zakład Biofizyki Farmaceutycznej
dc.abstract.enThe chromatographic parameters of arylpiperazinylpropyl derivatives of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione were investigated using reversed-phase thin layer chromatography method. The results revealed that RM0 of investigated compounds depended on substituent in arylpiperazinyl fragment as well as on a nature of (cycloalkyl)aromatic ring at 5 position of imidazolidine-2,4-dione and at 7 position of imidazo[2,1-f]theophylline. The RM0 parameters were compared with computationally calculated partition coefficients values by principal component analysis (PCA). To verify the influence of lipophilic parameter of investigated compounds on their biological activity the statistical analysis of Mann-Whitney was performed.pl
dc.affiliationWydział Farmaceutyczny : Zakład Chemii Lekówpl
dc.affiliationWydział Farmaceutyczny : Zakład Biofizyki Farmaceutycznejpl
dc.cm.date2020-01-07
dc.cm.id65323
dc.contributor.authorZagórska, Agnieszka - 133872 pl
dc.contributor.authorCzopek, Anna - 129115 pl
dc.contributor.authorPełka, Karolinapl
dc.contributor.authorStanisz-Wallis, Krystyna - 133476 pl
dc.contributor.authorPawłowski, Maciej - 133112 pl
dc.date.accession2016-10-03pl
dc.date.accessioned2020-01-17T08:42:39Z
dc.date.available2020-01-17T08:42:39Z
dc.date.issued2014pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 383pl
dc.description.number3pl
dc.description.physical379-383pl
dc.description.points15pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume71pl
dc.identifier.eissn2353-5288pl
dc.identifier.issn0001-6837pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/133384
dc.identifier.weblinkhttp://www.ptfarm.pl/pub/File/Acta_Poloniae/2014/3/379.pdfpl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enimidazolidine-2,4-dionespl
dc.subject.enimidazo[2,1-f]purine-2,4-dionespl
dc.subject.enlipophilicitypl
dc.subtypeArticlepl
dc.titleReversed-phase TLC study of some long chain arylpiperazine of imidazolidine-2,4-dione and imidazo[2,1-φ]purine-2,4-dione derivativespl
dc.title.journalActa Poloniae Pharmaceutica. Drug Researchpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
The chromatographic parameters of arylpiperazinylpropyl derivatives of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione were investigated using reversed-phase thin layer chromatography method. The results revealed that RM0 of investigated compounds depended on substituent in arylpiperazinyl fragment as well as on a nature of (cycloalkyl)aromatic ring at 5 position of imidazolidine-2,4-dione and at 7 position of imidazo[2,1-f]theophylline. The RM0 parameters were compared with computationally calculated partition coefficients values by principal component analysis (PCA). To verify the influence of lipophilic parameter of investigated compounds on their biological activity the statistical analysis of Mann-Whitney was performed.
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Chemii Leków
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Biofizyki Farmaceutycznej
dc.cm.date
2020-01-07
dc.cm.id
65323
dc.contributor.authorpl
Zagórska, Agnieszka - 133872
dc.contributor.authorpl
Czopek, Anna - 129115
dc.contributor.authorpl
Pełka, Karolina
dc.contributor.authorpl
Stanisz-Wallis, Krystyna - 133476
dc.contributor.authorpl
Pawłowski, Maciej - 133112
dc.date.accessionpl
2016-10-03
dc.date.accessioned
2020-01-17T08:42:39Z
dc.date.available
2020-01-17T08:42:39Z
dc.date.issuedpl
2014
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 383
dc.description.numberpl
3
dc.description.physicalpl
379-383
dc.description.pointspl
15
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
71
dc.identifier.eissnpl
2353-5288
dc.identifier.issnpl
0001-6837
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/133384
dc.identifier.weblinkpl
http://www.ptfarm.pl/pub/File/Acta_Poloniae/2014/3/379.pdf
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC
dc.rights.uri*
http://creativecommons.org/licenses/by-nc/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
imidazolidine-2,4-diones
dc.subject.enpl
imidazo[2,1-f]purine-2,4-diones
dc.subject.enpl
lipophilicity
dc.subtypepl
Article
dc.titlepl
Reversed-phase TLC study of some long chain arylpiperazine of imidazolidine-2,4-dione and imidazo[2,1-φ]purine-2,4-dione derivatives
dc.title.journalpl
Acta Poloniae Pharmaceutica. Drug Research
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations
Wydział Farmaceutyczny
Zagórska, Agnieszka
Czopek, Anna
Pełka, Karolina
Stanisz-Wallis, Krystyna
Pawłowski, Maciej

* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.

Views
13
Views per month
Views per city
Des Moines
3
Wroclaw
2
Denver
1
Dublin
1
Hanoi
1
Houston
1
Moscow
1
Shanghai
1
Downloads
zagorska_et-al_reversed-phase_tlc_study_of_some_long_chain_arylpiperazine_2014.pdf
6
zagorska_et-al_reversed-phase_tlc_study_of_some_long_chain_arylpiperazine_2014.odt
3

Open Access

Thumbnail Image
License
CC-BY-NC

Except as otherwise noted, this item is licensed under : Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa

Collections
Research publications
Medical sciences
Publications of the Medical College
ROD UJ