Organ atrophy induced by sorafenib and sunitinib : quantitative computed tomography (CT) evaluation of the pancreas, thyroid gland and spleen

2016
journal article
article
cris.lastimport.wos2024-04-09T23:31:39Z
dc.abstract.enBACKGROUND: To evaluate organ atrophy induced by sorafenib and sunitinib, we retrospectively reviewed the CT scans of renal cell carcinoma (RCC) patients receiving molecular targeted therapy (MTT) using sorafenib or sunitinib, and performed volumetric analysis of the pancreas, thyroid gland, and spleen. MATERIAL AND METHODS: Thirteen RCC patients receiving MTT were assigned as the evaluation cases (MTT group), while thirteen additional RCC patients not receiving MTT were retrieved as the Control group. We evaluated the baseline and follow-up CT studies. The volume of the three organs estimated by CT volumetry was compared between the baseline and follow-up CTs. The atrophic ratio of the organ volume in the follow-up CT to that in the baseline CT was calculated, and compared between the MTT and Control groups. RESULTS: All measured organs in the MTT group showed statistically significant volume loss, while no significant change was observed in the Control group. Mean atrophic ratio in the MTT group was 0.74, 0.58, and 0.82 for the pancreas, thyroid and spleen, respectively. The differences in atrophic ratios between both groups were all statistically significant (P<0.05). CONCLUSIONS: Single-agent sorafenib or sunitinib therapy induced statistically significant atrophy in the pancreas, thyroid, and spleen.pl
dc.contributor.authorTakahashi, Hiroakipl
dc.contributor.authorNasu, Katsuhiropl
dc.contributor.authorMinami, Manabupl
dc.contributor.authorKojima, Takahiropl
dc.contributor.authorNishiyama, Hiroyukipl
dc.contributor.authorIshiguro, Toshitakapl
dc.contributor.authorKonishi, Takahiropl
dc.date.accessioned2017-05-10T09:58:05Z
dc.date.available2017-05-10T09:58:05Z
dc.date.issued2016pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 564-565pl
dc.description.physical557-565pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume81pl
dc.identifier.doi10.12659/PJR.898936pl
dc.identifier.eissn1899-0967pl
dc.identifier.issn1733-134Xpl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/40364
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode*
dc.share.typeotwarte czasopismo
dc.subject.enatrophypl
dc.subject.enpancreaspl
dc.subject.enspleenpl
dc.subject.enthyroid glandpl
dc.subtypeArticlepl
dc.titleOrgan atrophy induced by sorafenib and sunitinib : quantitative computed tomography (CT) evaluation of the pancreas, thyroid gland and spleenpl
dc.title.journalPolish Journal of Radiologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T23:31:39Z
dc.abstract.enpl
BACKGROUND: To evaluate organ atrophy induced by sorafenib and sunitinib, we retrospectively reviewed the CT scans of renal cell carcinoma (RCC) patients receiving molecular targeted therapy (MTT) using sorafenib or sunitinib, and performed volumetric analysis of the pancreas, thyroid gland, and spleen. MATERIAL AND METHODS: Thirteen RCC patients receiving MTT were assigned as the evaluation cases (MTT group), while thirteen additional RCC patients not receiving MTT were retrieved as the Control group. We evaluated the baseline and follow-up CT studies. The volume of the three organs estimated by CT volumetry was compared between the baseline and follow-up CTs. The atrophic ratio of the organ volume in the follow-up CT to that in the baseline CT was calculated, and compared between the MTT and Control groups. RESULTS: All measured organs in the MTT group showed statistically significant volume loss, while no significant change was observed in the Control group. Mean atrophic ratio in the MTT group was 0.74, 0.58, and 0.82 for the pancreas, thyroid and spleen, respectively. The differences in atrophic ratios between both groups were all statistically significant (P<0.05). CONCLUSIONS: Single-agent sorafenib or sunitinib therapy induced statistically significant atrophy in the pancreas, thyroid, and spleen.
dc.contributor.authorpl
Takahashi, Hiroaki
dc.contributor.authorpl
Nasu, Katsuhiro
dc.contributor.authorpl
Minami, Manabu
dc.contributor.authorpl
Kojima, Takahiro
dc.contributor.authorpl
Nishiyama, Hiroyuki
dc.contributor.authorpl
Ishiguro, Toshitaka
dc.contributor.authorpl
Konishi, Takahiro
dc.date.accessioned
2017-05-10T09:58:05Z
dc.date.available
2017-05-10T09:58:05Z
dc.date.issuedpl
2016
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 564-565
dc.description.physicalpl
557-565
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
81
dc.identifier.doipl
10.12659/PJR.898936
dc.identifier.eissnpl
1899-0967
dc.identifier.issnpl
1733-134X
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/40364
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode
dc.share.type
otwarte czasopismo
dc.subject.enpl
atrophy
dc.subject.enpl
pancreas
dc.subject.enpl
spleen
dc.subject.enpl
thyroid gland
dc.subtypepl
Article
dc.titlepl
Organ atrophy induced by sorafenib and sunitinib : quantitative computed tomography (CT) evaluation of the pancreas, thyroid gland and spleen
dc.title.journalpl
Polish Journal of Radiology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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