Flow structures and red blood cell dynamics in arteriole of dilated or constricted cross section

2016
journal article
conference proceedings
cris.lastimport.wos2024-04-09T21:33:33Z
dc.abstract.enVessel with ‘circular’ or ‘star-shaped’ cross sections are studied, representing respectively dilated or constricted cases where endothelial cells smoothly line or bulge into the lumen. Computational haemodynamics simulations are carried out on idealised periodic arteriole-sized vessels, with red blood cell ‘tube’ hematocrit value=24%. A further simulation of a single red blood cell serves for comparison purposes. The bulk motion of the red blood cells reproduces well-known effects, including the presence of a cell-free layer and the apparent shear-thinning non-Newtonian rheology. The velocity flow field is analysed in a Lagrangian reference frame, relative to any given red blood cell, hence removing the bulk coaxial motion and highlighting instead the complex secondary flow patterns. An aggregate formation becomes apparent, continuously rearranging and dynamic, brought about by the inter-cellular fluid mechanics interactions and the deformability properties of the cells. The secondary flow field induces a vacillating radial migration of the red blood cells. At different radial locations, the red blood cells express different residence times, orientation and shape. The shear stresses exerted by the flow on the vessel wall are influenced by the motion of red blood cells, despite the presence of the cell-free layer. Spatial (and temporal) variations of wall shear stress patters are observed, especially for the ‘circular’ vessel. The ‘star-shaped’ vessel bears considerable stress at the protruding endothelial cell crests, where the stress vectors are coaxially aligned. The bulging endothelial cells hence regularise the transmission of stresses on the vessel wall.pl
dc.affiliationWydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiegopl
dc.conferenceInternational Conference on CFD in Medicine and Biologypl
dc.conference.cityAlbufeira
dc.conference.countryPortugalia
dc.conference.datefinish2015-09-04
dc.conference.datestart2015-08-30
dc.conference.indexscopustrue
dc.conference.indexwostrue
dc.contributor.authorGambaruto, Alberto M.pl
dc.date.accessioned2016-10-11T10:27:59Z
dc.date.available2016-10-11T10:27:59Z
dc.date.issued2016pl
dc.description.conftypeinternationalpl
dc.description.number11pl
dc.description.physical2229-2240pl
dc.description.volume49pl
dc.identifier.doi10.1016/j.jbiomech.2015.11.023pl
dc.identifier.eissn1873-2380pl
dc.identifier.issn0021-9290pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/31366
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licencebez licencji
dc.rights.uri*
dc.subject.encomputational haemodynamicspl
dc.subject.enmicrocirculationpl
dc.subject.enred blood cellspl
dc.subject.encell migrationpl
dc.subject.enwall shear stresspl
dc.subject.ensecondary flow structurespl
dc.subject.endilated vesselspl
dc.subject.enconstricted vesselspl
dc.subtypeConferenceProceedingspl
dc.titleFlow structures and red blood cell dynamics in arteriole of dilated or constricted cross sectionpl
dc.title.journalJournal of Biomechanicspl
dc.title.volumeSelected articles from the International Conference on CFD in Medicine and Biology (Albufeira, Portugal – August 30th - September 4th, 2015)pl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T21:33:33Z
dc.abstract.enpl
Vessel with ‘circular’ or ‘star-shaped’ cross sections are studied, representing respectively dilated or constricted cases where endothelial cells smoothly line or bulge into the lumen. Computational haemodynamics simulations are carried out on idealised periodic arteriole-sized vessels, with red blood cell ‘tube’ hematocrit value=24%. A further simulation of a single red blood cell serves for comparison purposes. The bulk motion of the red blood cells reproduces well-known effects, including the presence of a cell-free layer and the apparent shear-thinning non-Newtonian rheology. The velocity flow field is analysed in a Lagrangian reference frame, relative to any given red blood cell, hence removing the bulk coaxial motion and highlighting instead the complex secondary flow patterns. An aggregate formation becomes apparent, continuously rearranging and dynamic, brought about by the inter-cellular fluid mechanics interactions and the deformability properties of the cells. The secondary flow field induces a vacillating radial migration of the red blood cells. At different radial locations, the red blood cells express different residence times, orientation and shape. The shear stresses exerted by the flow on the vessel wall are influenced by the motion of red blood cells, despite the presence of the cell-free layer. Spatial (and temporal) variations of wall shear stress patters are observed, especially for the ‘circular’ vessel. The ‘star-shaped’ vessel bears considerable stress at the protruding endothelial cell crests, where the stress vectors are coaxially aligned. The bulging endothelial cells hence regularise the transmission of stresses on the vessel wall.
dc.affiliationpl
Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego
dc.conferencepl
International Conference on CFD in Medicine and Biology
dc.conference.city
Albufeira
dc.conference.country
Portugalia
dc.conference.datefinish
2015-09-04
dc.conference.datestart
2015-08-30
dc.conference.indexscopus
true
dc.conference.indexwos
true
dc.contributor.authorpl
Gambaruto, Alberto M.
dc.date.accessioned
2016-10-11T10:27:59Z
dc.date.available
2016-10-11T10:27:59Z
dc.date.issuedpl
2016
dc.description.conftypepl
international
dc.description.numberpl
11
dc.description.physicalpl
2229-2240
dc.description.volumepl
49
dc.identifier.doipl
10.1016/j.jbiomech.2015.11.023
dc.identifier.eissnpl
1873-2380
dc.identifier.issnpl
0021-9290
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/31366
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
bez licencji
dc.rights.uri*
dc.subject.enpl
computational haemodynamics
dc.subject.enpl
microcirculation
dc.subject.enpl
red blood cells
dc.subject.enpl
cell migration
dc.subject.enpl
wall shear stress
dc.subject.enpl
secondary flow structures
dc.subject.enpl
dilated vessels
dc.subject.enpl
constricted vessels
dc.subtypepl
ConferenceProceedings
dc.titlepl
Flow structures and red blood cell dynamics in arteriole of dilated or constricted cross section
dc.title.journalpl
Journal of Biomechanics
dc.title.volumepl
Selected articles from the International Conference on CFD in Medicine and Biology (Albufeira, Portugal – August 30th - September 4th, 2015)
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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