Determination of azole antifungal medicines using zero-order and derivative UV spectrophotometry

2009
journal article
article
dc.abstract.enThis paper presents a new methodology of quantitative determination of seven azole antifungal medicines widely used in therapy. Analyses were performed directly by using zero-order (fluconazole), first derivative (bifonazole, clotrimazole, econazole, itraconazole, miconazole) and second derivative (ketoconazole) UV spectrophotometry. Validation of all methods confirms their proper precision (%RSD = 0.47 - 2.86), recovery (98.7 - 101.4) and linearity (r coefficient over 0,999) in concentrations under investigation. The parameters received enable the developed procedure to be used in quantitative and as auxiliary in qualitative pharmaceutical analysis.pl
dc.affiliationWydział Farmaceutyczny : Zakład Chemii Analitycznejpl
dc.contributor.authorEkiert, Radosław - 147732 pl
dc.contributor.authorKrzek, Jan - 130468 pl
dc.date.accession2020-07-29pl
dc.date.accessioned2020-07-29T07:59:50Z
dc.date.available2020-07-29T07:59:50Z
dc.date.issued2009pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 23-24pl
dc.description.number1pl
dc.description.physical19-24pl
dc.description.publication0,41pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume66pl
dc.identifier.eissn2353-5288pl
dc.identifier.issn0001-6837pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/243012
dc.identifier.weblinkhttps://www.ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/11611pl
dc.languageengpl
dc.language.containerpolpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enazole antifungal medicinespl
dc.subject.enzero-order and derivative UV spectrophotometrypl
dc.subject.enpharmaceutical analysispl
dc.subtypeArticlepl
dc.titleDetermination of azole antifungal medicines using zero-order and derivative UV spectrophotometrypl
dc.title.journalActa Poloniae Pharmaceutica. Drug Researchpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
This paper presents a new methodology of quantitative determination of seven azole antifungal medicines widely used in therapy. Analyses were performed directly by using zero-order (fluconazole), first derivative (bifonazole, clotrimazole, econazole, itraconazole, miconazole) and second derivative (ketoconazole) UV spectrophotometry. Validation of all methods confirms their proper precision (%RSD = 0.47 - 2.86), recovery (98.7 - 101.4) and linearity (r coefficient over 0,999) in concentrations under investigation. The parameters received enable the developed procedure to be used in quantitative and as auxiliary in qualitative pharmaceutical analysis.
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Chemii Analitycznej
dc.contributor.authorpl
Ekiert, Radosław - 147732
dc.contributor.authorpl
Krzek, Jan - 130468
dc.date.accessionpl
2020-07-29
dc.date.accessioned
2020-07-29T07:59:50Z
dc.date.available
2020-07-29T07:59:50Z
dc.date.issuedpl
2009
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 23-24
dc.description.numberpl
1
dc.description.physicalpl
19-24
dc.description.publicationpl
0,41
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
66
dc.identifier.eissnpl
2353-5288
dc.identifier.issnpl
0001-6837
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/243012
dc.identifier.weblinkpl
https://www.ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/11611
dc.languagepl
eng
dc.language.containerpl
pol
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC
dc.rights.uri*
http://creativecommons.org/licenses/by-nc/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
azole antifungal medicines
dc.subject.enpl
zero-order and derivative UV spectrophotometry
dc.subject.enpl
pharmaceutical analysis
dc.subtypepl
Article
dc.titlepl
Determination of azole antifungal medicines using zero-order and derivative UV spectrophotometry
dc.title.journalpl
Acta Poloniae Pharmaceutica. Drug Research
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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