Chicken or egg? : outcomes of experimental manipulations of maternally transmitted hormones depend on administration method : a meta‐analysis

2018
journal article
article
dc.abstract.enSteroid hormones are important mediators of prenatal maternal effects in animals. Despite a growing number of studies involving experimental manipulation of these hormones, little is known about the impact of methodological differences among experiments on the final results expressed as offspring traits. Using ameta-analytical approach and a representative sample of experimental studies performed on birds, we tested the effect of two types of direct hormonal manipulations: manipulation of females (either by implantation of hormone pellets or injection of hormonal solutions) andmanipulation of eggs by injection. In both types ofmanipulation we looked at the effects of two groups of hormones: corticosterone and androgens in the form of testosterone and androstenedione. We found that the average effect on offspring traits differed between the manipulation types, with a well-supported positive effect of egg manipulation and lack of a significant effect of maternal manipulation. The observed average positive effect for egg manipulation was driven mainly by androgen manipulations, while corticosterone manipulations exerted no overall effect, regardless of manipulation type. Detailed analyses revealed effects of varying size and direction depending on the specific offspring traits; e.g., egg manipulation positively affected physiology and behaviour (androgens), and negatively affected future reproduction (corticosterone). Effect size was negatively related to the dose of androgen injected into the eggs, but unrelated to timing of manipulation, offspring developmental stage at the time of measuring their traits, solvent type, the site of egg injection and maternal hormone delivery method. Despite the generally acknowledged importance of maternal hormones for offspring development in birds, the overall effect of their experimental elevation is rather weak, significantly heterogeneous and dependent on the hormone and type of manipulation. We conclude by providing general recommendations as to how hormonalmanipulations should be performed in order to standardize their impact and the results achieved. We also emphasize the need for research on free-living birds with a focus on fitness-related and other long-term effects of maternal hormones.pl
dc.affiliationWydział Biologii : Instytut Nauk o Środowiskupl
dc.contributor.authorPodmokła, Edyta - 104185 pl
dc.contributor.authorDrobniak, Szymon - 103910 pl
dc.contributor.authorRutkowska, Joanna - 131733 pl
dc.date.accessioned2018-07-23T06:27:05Z
dc.date.available2018-07-23T06:27:05Z
dc.date.issued2018pl
dc.description.additionalBibliogr. s. 1513-1517pl
dc.description.number3pl
dc.description.physical1499-1517pl
dc.description.volume93pl
dc.identifier.doi10.1111/brv.12406pl
dc.identifier.eissn1469-185Xpl
dc.identifier.issn1464-7931pl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/56043
dc.languageengpl
dc.language.containerengpl
dc.participationRutkowska, Joanna: 20%; Drobniak, Szymon: 40%; Podmokła, Edyta: 40%;pl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licencebez licencji
dc.rights.uri*
dc.subject.enmaternal effects, offspring fitness, development, avian egg, yolk steroids, androgen, corticosterone, testosterone, phenotypic plasticity, experimental designpl
dc.subtypeArticlepl
dc.titleChicken or egg? : outcomes of experimental manipulations of maternally transmitted hormones depend on administration method : a meta‐analysispl
dc.title.journalBiological Reviewspl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Steroid hormones are important mediators of prenatal maternal effects in animals. Despite a growing number of studies involving experimental manipulation of these hormones, little is known about the impact of methodological differences among experiments on the final results expressed as offspring traits. Using ameta-analytical approach and a representative sample of experimental studies performed on birds, we tested the effect of two types of direct hormonal manipulations: manipulation of females (either by implantation of hormone pellets or injection of hormonal solutions) andmanipulation of eggs by injection. In both types ofmanipulation we looked at the effects of two groups of hormones: corticosterone and androgens in the form of testosterone and androstenedione. We found that the average effect on offspring traits differed between the manipulation types, with a well-supported positive effect of egg manipulation and lack of a significant effect of maternal manipulation. The observed average positive effect for egg manipulation was driven mainly by androgen manipulations, while corticosterone manipulations exerted no overall effect, regardless of manipulation type. Detailed analyses revealed effects of varying size and direction depending on the specific offspring traits; e.g., egg manipulation positively affected physiology and behaviour (androgens), and negatively affected future reproduction (corticosterone). Effect size was negatively related to the dose of androgen injected into the eggs, but unrelated to timing of manipulation, offspring developmental stage at the time of measuring their traits, solvent type, the site of egg injection and maternal hormone delivery method. Despite the generally acknowledged importance of maternal hormones for offspring development in birds, the overall effect of their experimental elevation is rather weak, significantly heterogeneous and dependent on the hormone and type of manipulation. We conclude by providing general recommendations as to how hormonalmanipulations should be performed in order to standardize their impact and the results achieved. We also emphasize the need for research on free-living birds with a focus on fitness-related and other long-term effects of maternal hormones.
dc.affiliationpl
Wydział Biologii : Instytut Nauk o Środowisku
dc.contributor.authorpl
Podmokła, Edyta - 104185
dc.contributor.authorpl
Drobniak, Szymon - 103910
dc.contributor.authorpl
Rutkowska, Joanna - 131733
dc.date.accessioned
2018-07-23T06:27:05Z
dc.date.available
2018-07-23T06:27:05Z
dc.date.issuedpl
2018
dc.description.additionalpl
Bibliogr. s. 1513-1517
dc.description.numberpl
3
dc.description.physicalpl
1499-1517
dc.description.volumepl
93
dc.identifier.doipl
10.1111/brv.12406
dc.identifier.eissnpl
1469-185X
dc.identifier.issnpl
1464-7931
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/56043
dc.languagepl
eng
dc.language.containerpl
eng
dc.participationpl
Rutkowska, Joanna: 20%; Drobniak, Szymon: 40%; Podmokła, Edyta: 40%;
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
bez licencji
dc.rights.uri*
dc.subject.enpl
maternal effects, offspring fitness, development, avian egg, yolk steroids, androgen, corticosterone, testosterone, phenotypic plasticity, experimental design
dc.subtypepl
Article
dc.titlepl
Chicken or egg? : outcomes of experimental manipulations of maternally transmitted hormones depend on administration method : a meta‐analysis
dc.title.journalpl
Biological Reviews
dc.typepl
JournalArticle
dspace.entity.type
Publication

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