Typical variant of takotsubo cardiomyopathy in oncological patients : two case reports and review of the literature

2020
journal article
article
2
dc.abstract.enTakotsubo cardiomyopathy (TCM) represents an acute systolic left ventricular dysfunction typically triggered by severe psychological or physical stress. Oncological patients due to emotional distress of the diagnosis, proinflammatory and prothrombotic nature of cancer and also physical stress often following complex anticancer therapies are at high-risk of TCM. Moreover, there are also few reports of TCM associated with oncological treatment, mostly chemotherapy. Recent data from large registries indicate a surprisingly high incidence of malignancy in TCM, significant differences in clinical characteristics and unfavorable short- and long-term clinical outcomes in this specific group of patients. Therefore, we present two case reports of TCM that occurred during active anticancer therapy. Both women were admitted with suspicion of acute coronary syndrome. The first patient underwent mastectomy two years before due to hormone receptor-positive breast cancer and on admission she was during adjuvant hormonotherapy with tamoxifen. The admission of the second patient was preceded by fifteen fractions of adjuvant external beam radiotherapy due to intermediate-risk endometrial cancer after radical hysterectomy. Based on coronary angiography type I of acute coronary syndrome was excluded. Both patients negated stressful situations in the period immediately before the symptoms onset. Within hospital course baseline apical ballooning observed in both cases fully recovered and enabled subsequent completion of oncological treatment in accordance with adopted treatment protocols without recurrence of TCM. To our knowledge, presented cases are the first reports showing direct relationship between TCM and adjuvant hormonotherapy with tamoxifen or pelvic radiotherapy.pl
dc.affiliationWydział Lekarski : Instytut Kardiologiipl
dc.cm.date2020-12-02
dc.cm.id99985
dc.contributor.authorStępień, Konradpl
dc.contributor.authorNowak, Karolpl
dc.contributor.authorPasieka, Pawełpl
dc.contributor.authorWarmuz, Konradpl
dc.contributor.authorStępień, Adampl
dc.contributor.authorNessler, Jadwiga - 131113 pl
dc.contributor.authorZalewski, Jarosław - 214058 pl
dc.date.accessioned2020-12-02T10:28:22Zpl
dc.date.available2020-12-02T10:28:22Zpl
dc.date.issued2020pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number1pl
dc.description.physical45-54pl
dc.description.points40pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume60pl
dc.identifier.doi10.24425/fmc.2020.133485pl
dc.identifier.issn0015-5616pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/257876
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/legalcode*
dc.share.typeotwarte czasopismo
dc.subject.entakotsubo cardiomyopathypl
dc.subject.enacute coronary syndromepl
dc.subject.enhormonotherapypl
dc.subject.enradiotherapypl
dc.subject.encardiooncologypl
dc.subtypeArticlepl
dc.titleTypical variant of takotsubo cardiomyopathy in oncological patients : two case reports and review of the literaturepl
dc.title.journalFolia Medica Cracoviensiapl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Takotsubo cardiomyopathy (TCM) represents an acute systolic left ventricular dysfunction typically triggered by severe psychological or physical stress. Oncological patients due to emotional distress of the diagnosis, proinflammatory and prothrombotic nature of cancer and also physical stress often following complex anticancer therapies are at high-risk of TCM. Moreover, there are also few reports of TCM associated with oncological treatment, mostly chemotherapy. Recent data from large registries indicate a surprisingly high incidence of malignancy in TCM, significant differences in clinical characteristics and unfavorable short- and long-term clinical outcomes in this specific group of patients. Therefore, we present two case reports of TCM that occurred during active anticancer therapy. Both women were admitted with suspicion of acute coronary syndrome. The first patient underwent mastectomy two years before due to hormone receptor-positive breast cancer and on admission she was during adjuvant hormonotherapy with tamoxifen. The admission of the second patient was preceded by fifteen fractions of adjuvant external beam radiotherapy due to intermediate-risk endometrial cancer after radical hysterectomy. Based on coronary angiography type I of acute coronary syndrome was excluded. Both patients negated stressful situations in the period immediately before the symptoms onset. Within hospital course baseline apical ballooning observed in both cases fully recovered and enabled subsequent completion of oncological treatment in accordance with adopted treatment protocols without recurrence of TCM. To our knowledge, presented cases are the first reports showing direct relationship between TCM and adjuvant hormonotherapy with tamoxifen or pelvic radiotherapy.
dc.affiliationpl
Wydział Lekarski : Instytut Kardiologii
dc.cm.date
2020-12-02
dc.cm.id
99985
dc.contributor.authorpl
Stępień, Konrad
dc.contributor.authorpl
Nowak, Karol
dc.contributor.authorpl
Pasieka, Paweł
dc.contributor.authorpl
Warmuz, Konrad
dc.contributor.authorpl
Stępień, Adam
dc.contributor.authorpl
Nessler, Jadwiga - 131113
dc.contributor.authorpl
Zalewski, Jarosław - 214058
dc.date.accessionedpl
2020-12-02T10:28:22Z
dc.date.availablepl
2020-12-02T10:28:22Z
dc.date.issuedpl
2020
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
1
dc.description.physicalpl
45-54
dc.description.pointspl
40
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
60
dc.identifier.doipl
10.24425/fmc.2020.133485
dc.identifier.issnpl
0015-5616
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/257876
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
https://creativecommons.org/licenses/by-nc-nd/3.0/legalcode
dc.share.type
otwarte czasopismo
dc.subject.enpl
takotsubo cardiomyopathy
dc.subject.enpl
acute coronary syndrome
dc.subject.enpl
hormonotherapy
dc.subject.enpl
radiotherapy
dc.subject.enpl
cardiooncology
dc.subtypepl
Article
dc.titlepl
Typical variant of takotsubo cardiomyopathy in oncological patients : two case reports and review of the literature
dc.title.journalpl
Folia Medica Cracoviensia
dc.typepl
JournalArticle
dspace.entity.type
Publication

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