Phosphine derivatives of ciprofloxacin and norfloxacin, a new class of potential therapeutic agents

2014
journal article
article
33
dc.abstract.enIn this paper a new series of chalcogenides of diphenylmethylaminophosphine derived from ciprofloxacin (PPh 2 CH 2 Cp) and a new phosphine derived from norfloxacin (PPh 2 CH 2 Nr) are presented. The synthesized compounds were characterized by N MR, MS and X-ray techniques. Both phosphines exhibit antibacterial activity against: S. aureus , E. coli , K. pneumoniae and P. aeruginosa , similar to ciprofloxacin and norfloxacin. They inhibit the growth of microorganisms in relatively low concentrations. Chalcogenides are slightly less active than phosphines and unmodified a ntibiotics. All the derivatives were also tested in vitro as anticancer agents towards mouse colon carcinoma (CT26) and human lung adenocarcinoma (A549). Cytotoxicity studies revealed that phosphines and their chalcogenides are able to inhibit the proliferation of the cells at relatively low concentrations. Moreover, all the tested compounds are more active against tested cell lines than cisplatin – the main representative of antitumor drugs.pl
dc.affiliationWydział Chemii : Zakład Chemii Nieorganicznejpl
dc.contributor.authorBykowska, Aleksandrapl
dc.contributor.authorStarosta, Radosławpl
dc.contributor.authorKomarnicka, Urszula K.pl
dc.contributor.authorCiunik, Zbigniewpl
dc.contributor.authorKyzioł, Agnieszka - 147927 pl
dc.contributor.authorGuz-Regner, Katarzynapl
dc.contributor.authorBugla-Płoskońska, Gabrielapl
dc.contributor.authorJeżowska-Bojczuk, Małgorzatapl
dc.date.accessioned2015-06-11T08:38:51Z
dc.date.available2015-06-11T08:38:51Z
dc.date.issued2014pl
dc.description.number3pl
dc.description.physical1062-1071pl
dc.description.volume38pl
dc.identifier.doi10.1039/c3nj01243cpl
dc.identifier.eissn1369-9261pl
dc.identifier.issn1144-0546pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/9358
dc.languageengpl
dc.language.containerengpl
dc.rights.licencebez licencji
dc.subtypeArticlepl
dc.titlePhosphine derivatives of ciprofloxacin and norfloxacin, a new class of potential therapeutic agentspl
dc.title.journalNew Journal of Chemistrypl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
In this paper a new series of chalcogenides of diphenylmethylaminophosphine derived from ciprofloxacin (PPh 2 CH 2 Cp) and a new phosphine derived from norfloxacin (PPh 2 CH 2 Nr) are presented. The synthesized compounds were characterized by N MR, MS and X-ray techniques. Both phosphines exhibit antibacterial activity against: S. aureus , E. coli , K. pneumoniae and P. aeruginosa , similar to ciprofloxacin and norfloxacin. They inhibit the growth of microorganisms in relatively low concentrations. Chalcogenides are slightly less active than phosphines and unmodified a ntibiotics. All the derivatives were also tested in vitro as anticancer agents towards mouse colon carcinoma (CT26) and human lung adenocarcinoma (A549). Cytotoxicity studies revealed that phosphines and their chalcogenides are able to inhibit the proliferation of the cells at relatively low concentrations. Moreover, all the tested compounds are more active against tested cell lines than cisplatin – the main representative of antitumor drugs.
dc.affiliationpl
Wydział Chemii : Zakład Chemii Nieorganicznej
dc.contributor.authorpl
Bykowska, Aleksandra
dc.contributor.authorpl
Starosta, Radosław
dc.contributor.authorpl
Komarnicka, Urszula K.
dc.contributor.authorpl
Ciunik, Zbigniew
dc.contributor.authorpl
Kyzioł, Agnieszka - 147927
dc.contributor.authorpl
Guz-Regner, Katarzyna
dc.contributor.authorpl
Bugla-Płoskońska, Gabriela
dc.contributor.authorpl
Jeżowska-Bojczuk, Małgorzata
dc.date.accessioned
2015-06-11T08:38:51Z
dc.date.available
2015-06-11T08:38:51Z
dc.date.issuedpl
2014
dc.description.numberpl
3
dc.description.physicalpl
1062-1071
dc.description.volumepl
38
dc.identifier.doipl
10.1039/c3nj01243c
dc.identifier.eissnpl
1369-9261
dc.identifier.issnpl
1144-0546
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/9358
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights.licence
bez licencji
dc.subtypepl
Article
dc.titlepl
Phosphine derivatives of ciprofloxacin and norfloxacin, a new class of potential therapeutic agents
dc.title.journalpl
New Journal of Chemistry
dc.typepl
JournalArticle
dspace.entity.type
Publication

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