Prevalence of hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) in the population of adult asthmatics in Poland based on an epidemiological questionnaire

2009
journal article
article
dc.abstract.enIntroduction: Hypersensitivity reactions to drugs account for 25% of all side effects related to drugs, affecting more than 7% of the population. One in four such reactions is caused by acetylic acid and other non-steroidal anti-inflammatory drugs. Material and methods: Between 1998 and 2000 epidemiological research was carried out in various centers, with the aim of estimating the frequency of allergy-based diseases in Poland. The objective of the study was to evaluate the frequency of hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs), based on an epidemiological questionnaire, in the Polish adult population. Results: Bronchial asthma was diagnosed in 582 patients (5.4%). Of that group, 75 patients (12.9%) additionally reported symptoms of hypersensitivity to NSAIDs. Aspirin-induced asthma was diagnosed in 11 patients (14.7%) with clinical manifestations of hypersensitivity responses. Frequency of aspirin-induced asthma with clinical symptoms amounted to 1.9% of asthmatics. In the assessment of severity of the disease, aspirin intolerance was the only statistically significant factor (p = 0.0003; odds ratio 28.6 with assumed 95% confidence interval). Conclusions: In the population of adults in Poland, the frequency of aspirin-induced asthma amounted to 0.1%. Hypersensitivity to NSAIDs was observed in 12.9% of asthmatics. In asthmatics with symptoms of hypersensitivity to non-steroidal anti-inflammatory drugs, which takes the course of clinically demonstrable aspirin-induced asthma, the risk of severe asthma is 30-fold higher.pl
dc.affiliationWydział Lekarskipl
dc.contributor.authorKasper, Łukasz - 130034 pl
dc.contributor.authorSładek, Krzysztof - 133426 pl
dc.contributor.authorBochenek, Grażyna - 128796 pl
dc.contributor.authorDuplaga, Mariusz - 129287 pl
dc.contributor.authorSzczeklik, Andrzej - 133558 pl
dc.date.accession2020-06-29pl
dc.date.accessioned2020-06-29T12:20:06Z
dc.date.available2020-06-29T12:20:06Z
dc.date.issued2009pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 438-439.pl
dc.description.number5pl
dc.description.physical431-439pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume77pl
dc.identifier.eissn2299-8292pl
dc.identifier.issn0867-7077pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/158865
dc.identifier.weblinkhttps://journals.viamedica.pl/advances_in_respiratory_medicine/article/view/27776/22548pl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enasthmapl
dc.subject.enprevalencepl
dc.subject.enaspirin induced asthmapl
dc.subject.ennon-steroidal anti-inflammatory drugspl
dc.subject.enhypersensitivitypl
dc.subtypeArticlepl
dc.titlePrevalence of hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) in the population of adult asthmatics in Poland based on an epidemiological questionnairepl
dc.title.journalPneumonologia i Alergologia Polskapl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Introduction: Hypersensitivity reactions to drugs account for 25% of all side effects related to drugs, affecting more than 7% of the population. One in four such reactions is caused by acetylic acid and other non-steroidal anti-inflammatory drugs. Material and methods: Between 1998 and 2000 epidemiological research was carried out in various centers, with the aim of estimating the frequency of allergy-based diseases in Poland. The objective of the study was to evaluate the frequency of hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs), based on an epidemiological questionnaire, in the Polish adult population. Results: Bronchial asthma was diagnosed in 582 patients (5.4%). Of that group, 75 patients (12.9%) additionally reported symptoms of hypersensitivity to NSAIDs. Aspirin-induced asthma was diagnosed in 11 patients (14.7%) with clinical manifestations of hypersensitivity responses. Frequency of aspirin-induced asthma with clinical symptoms amounted to 1.9% of asthmatics. In the assessment of severity of the disease, aspirin intolerance was the only statistically significant factor (p = 0.0003; odds ratio 28.6 with assumed 95% confidence interval). Conclusions: In the population of adults in Poland, the frequency of aspirin-induced asthma amounted to 0.1%. Hypersensitivity to NSAIDs was observed in 12.9% of asthmatics. In asthmatics with symptoms of hypersensitivity to non-steroidal anti-inflammatory drugs, which takes the course of clinically demonstrable aspirin-induced asthma, the risk of severe asthma is 30-fold higher.
dc.affiliationpl
Wydział Lekarski
dc.contributor.authorpl
Kasper, Łukasz - 130034
dc.contributor.authorpl
Sładek, Krzysztof - 133426
dc.contributor.authorpl
Bochenek, Grażyna - 128796
dc.contributor.authorpl
Duplaga, Mariusz - 129287
dc.contributor.authorpl
Szczeklik, Andrzej - 133558
dc.date.accessionpl
2020-06-29
dc.date.accessioned
2020-06-29T12:20:06Z
dc.date.available
2020-06-29T12:20:06Z
dc.date.issuedpl
2009
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 438-439.
dc.description.numberpl
5
dc.description.physicalpl
431-439
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
77
dc.identifier.eissnpl
2299-8292
dc.identifier.issnpl
0867-7077
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/158865
dc.identifier.weblinkpl
https://journals.viamedica.pl/advances_in_respiratory_medicine/article/view/27776/22548
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
asthma
dc.subject.enpl
prevalence
dc.subject.enpl
aspirin induced asthma
dc.subject.enpl
non-steroidal anti-inflammatory drugs
dc.subject.enpl
hypersensitivity
dc.subtypepl
Article
dc.titlepl
Prevalence of hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) in the population of adult asthmatics in Poland based on an epidemiological questionnaire
dc.title.journalpl
Pneumonologia i Alergologia Polska
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.

Views
9
Views per month
Views per city
Ashburn
4
Boardman
2
Wroclaw
2
Dublin
1
Downloads
kasper_et-al_prevalence_of_hypersensitivity_to_non-steroidal_anti-inflammatory_drugs_2009.pdf
3