Preoperative Short-Course Radiotherapy and Surgery versus Surgery Alone for Patients with Rectal Cancer : A Propensity Score-Matched Analysis at 18-Year Follow-Up

2021
journal article
article
2
dc.abstract.enA significant problem for long-term rectal cancer survivors may be the late toxicity of radiotherapy. It creates the possible risk of developing second primary malignancy and a theoretical decrease in overall survival. This study aimed to assess the influence of short-course preoperative radiotherapy in patients with locally advanced rectal cancer on overall survival, local recurrence rate, and second malignancy at 18-year follow-up. The rectal cancer trial was conducted in a single tertiary center between February 1992 and June 2006. A total of 389 patients with locally advanced rectal cancer (cT2-cT4, cN0/+, cM0) were included in the study. Preoperative radiotherapy was conducted in 148 patients and 241 patients underwent surgery alone. The propensity-matched group consisted of 105 patients operated on after radiotherapy and 105 controls. The number of local recurrences was 7 (6.7%) in the preoperative radiotherapy group and 22 (21%) in the surgery alone group (p = 0.016). The 18-year survival analysis showed no survival benefit in the preoperative radiotherapy group (38% versus 48%, p = 0.107) but improved recurrence-free survival (81% versus 58%, p = 0.001). The preoperative short-course radiotherapy significantly decreases the risk of local recurrence in locally advanced rectal cancer and may improve recurrence-free survival without an increased risk of second primary malignancy.pl
dc.affiliationWydział Nauk o Zdrowiu : Instytut Fizjoterapiipl
dc.affiliationWydział Lekarski : I Katedra Chirurgii Ogólnejpl
dc.affiliationWydział Lekarski : Klinika Chirurgii Ogólnej, Onkologicznej i Gastroenterologicznejpl
dc.cm.id105045
dc.cm.idOmegaUJCM1125aef0f2e648e3a6c742c95b031361pl
dc.contributor.authorPach, Radosław - 161566 pl
dc.contributor.authorRichter, Piotr - 133277 pl
dc.contributor.authorSierżęga, Marek - 133388 pl
dc.contributor.authorPapp, Nataliapl
dc.contributor.authorSzczepanik, Marian - 133568 pl
dc.date.accession2021-12-10pl
dc.date.accessioned2021-12-10T15:17:07Z
dc.date.available2021-12-10T15:17:07Z
dc.date.issued2021pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number7pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume9pl
dc.identifier.articleid725pl
dc.identifier.doi10.3390/biomedicines9070725pl
dc.identifier.eissn2227-9059pl
dc.identifier.issn2227-9059pl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/285042
dc.identifier.weblinkhttps://www.mdpi.com/2227-9059/9/7/725pl
dc.languageengpl
dc.language.containerengpl
dc.pbn.affiliationDziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licenceCC-BY
dc.rights.uri*
dc.share.typeOtwarte czasopismo
dc.subtypeArticlepl
dc.titlePreoperative Short-Course Radiotherapy and Surgery versus Surgery Alone for Patients with Rectal Cancer : A Propensity Score-Matched Analysis at 18-Year Follow-Uppl
dc.title.journalBiomedicinespl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
A significant problem for long-term rectal cancer survivors may be the late toxicity of radiotherapy. It creates the possible risk of developing second primary malignancy and a theoretical decrease in overall survival. This study aimed to assess the influence of short-course preoperative radiotherapy in patients with locally advanced rectal cancer on overall survival, local recurrence rate, and second malignancy at 18-year follow-up. The rectal cancer trial was conducted in a single tertiary center between February 1992 and June 2006. A total of 389 patients with locally advanced rectal cancer (cT2-cT4, cN0/+, cM0) were included in the study. Preoperative radiotherapy was conducted in 148 patients and 241 patients underwent surgery alone. The propensity-matched group consisted of 105 patients operated on after radiotherapy and 105 controls. The number of local recurrences was 7 (6.7%) in the preoperative radiotherapy group and 22 (21%) in the surgery alone group (p = 0.016). The 18-year survival analysis showed no survival benefit in the preoperative radiotherapy group (38% versus 48%, p = 0.107) but improved recurrence-free survival (81% versus 58%, p = 0.001). The preoperative short-course radiotherapy significantly decreases the risk of local recurrence in locally advanced rectal cancer and may improve recurrence-free survival without an increased risk of second primary malignancy.
dc.affiliationpl
Wydział Nauk o Zdrowiu : Instytut Fizjoterapii
dc.affiliationpl
Wydział Lekarski : I Katedra Chirurgii Ogólnej
dc.affiliationpl
Wydział Lekarski : Klinika Chirurgii Ogólnej, Onkologicznej i Gastroenterologicznej
dc.cm.id
105045
dc.cm.idOmegapl
UJCM1125aef0f2e648e3a6c742c95b031361
dc.contributor.authorpl
Pach, Radosław - 161566
dc.contributor.authorpl
Richter, Piotr - 133277
dc.contributor.authorpl
Sierżęga, Marek - 133388
dc.contributor.authorpl
Papp, Natalia
dc.contributor.authorpl
Szczepanik, Marian - 133568
dc.date.accessionpl
2021-12-10
dc.date.accessioned
2021-12-10T15:17:07Z
dc.date.available
2021-12-10T15:17:07Z
dc.date.issuedpl
2021
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
7
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
9
dc.identifier.articleidpl
725
dc.identifier.doipl
10.3390/biomedicines9070725
dc.identifier.eissnpl
2227-9059
dc.identifier.issnpl
2227-9059
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/285042
dc.identifier.weblinkpl
https://www.mdpi.com/2227-9059/9/7/725
dc.languagepl
eng
dc.language.containerpl
eng
dc.pbn.affiliation
Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
CC-BY
dc.rights.uri*
dc.share.type
Otwarte czasopismo
dc.subtypepl
Article
dc.titlepl
Preoperative Short-Course Radiotherapy and Surgery versus Surgery Alone for Patients with Rectal Cancer : A Propensity Score-Matched Analysis at 18-Year Follow-Up
dc.title.journalpl
Biomedicines
dc.typepl
JournalArticle
dspace.entity.type
Publication

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