Altered plasma cytokine levels in acute and chronic central serous chorioretinopathy

2021
journal article
article
19
cris.lastimport.wos2024-04-09T23:04:37Z
dc.abstract.enPurpose: To evaluate plasma levels of selected cytokines and investigate their correlation with choroidal thickness (CT) in patients with acute and chronic central serous chorioretinopathy (CSC). Methods: We enrolled 30 patients with acute CSC, 30 patients with chronic CSC and 20 controls. Plasma concentrations of 12 cytokines, interleukins IL-8, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-10 and IL-12 p70, granulocyte-macrophage colony-stimulating factor, interferon-c, tumour necrosis factor-a (TNF-a) and vascular endothelial growth factor (VEGF), were measured using multiplex immunoassays. Differences in cytokine levels between groups were assessed. We also investigated correlations between cytokine levels and CT using swept-source optical coherence tomography, as well as an association between plasma cytokine profile and systemic hypertension. Results: We noted differences in IL-6 (p = 0.005), IL-10 (p = 0.03), IL-12 p70 (p = 0.028) and VEGF (p = 0.029) levels between groups. Pro-inflammatory IL12 p70 and multidirectional IL-10 cytokines were upregulated, while proangiogenic VEGF was downregulated in chronic CSC as compared with controls (p = 0.005, p = 0.025 and p = 0.027, respectively). Interleukin-6 (IL-6) was upregulated in acute and chronic CSC (p = 0.030 and p = 0.005, respectively). Interleukin-5 (IL-5), IL-6 and IL-12 levels correlated with mean CT in acute CSC (p = 0.008, p = 0.003 and p = 0.044, respectively), while IL-8, IL-6 and TNF-a plasma levels correlated with hypertension in chronic CSC (p = 0.005, p = 0.033 and p = 0.001, respectively). Conclusion: We provided new evidence for the possible role of plasma cytokines in the pathogenesis of CSC. Our results suggest that IL-6 may be important in the pathophysiology of acute and chronic CSC. The association between inflammatory response and hypertension in patients with CSC was also confirmed.pl
dc.affiliationWydział Lekarski : Klinika Okulistyki i Onkologii Okulistycznejpl
dc.affiliationWydział Lekarski : Zakład Biologii Molekularnej i Genetyki Klinicznejpl
dc.cm.date2021-04-15
dc.cm.id100481
dc.cm.idOmegaUJCMe71d289174bb48008adad77f258bed6cpl
dc.contributor.authorKarska-Basta, Izabella - 130029 pl
dc.contributor.authorPociej-Marciak, Weronika - 141644 pl
dc.contributor.authorChrząszcz, Michałpl
dc.contributor.authorKubicka-Trząska, Agnieszka - 130507 pl
dc.contributor.authorRomanowska-Dixon, Bożena - 133294 pl
dc.contributor.authorSanak, Marek - 133357 pl
dc.date.accession2021-03-15pl
dc.date.accessioned2021-04-29T09:32:05Z
dc.date.available2021-04-29T09:32:05Z
dc.date.issued2021pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number2pl
dc.description.physicale222-e231pl
dc.description.points140
dc.description.versionostateczna wersja wydawcy
dc.description.volume99pl
dc.identifier.doi10.1111/aos.14547pl
dc.identifier.eissn1755-3768pl
dc.identifier.issn1755-375Xpl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/270517
dc.identifier.weblinkhttps://onlinelibrary.wiley.com/doi/full/10.1111/aos.14547
dc.languageengpl
dc.language.containerengpl
dc.pbn.affiliationDziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.relation.uri*
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeinne
dc.subject.encentral serous chorioretinopathypl
dc.subject.enchoroidal thicknesspl
dc.subject.encytokinespl
dc.subject.enhypertensionpl
dc.subject.eninflammationpl
dc.subject.eninterleukinspl
dc.subtypeArticlepl
dc.titleAltered plasma cytokine levels in acute and chronic central serous chorioretinopathypl
dc.title.journalActa Ophthalmologicapl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T23:04:37Z
dc.abstract.enpl
Purpose: To evaluate plasma levels of selected cytokines and investigate their correlation with choroidal thickness (CT) in patients with acute and chronic central serous chorioretinopathy (CSC). Methods: We enrolled 30 patients with acute CSC, 30 patients with chronic CSC and 20 controls. Plasma concentrations of 12 cytokines, interleukins IL-8, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-10 and IL-12 p70, granulocyte-macrophage colony-stimulating factor, interferon-c, tumour necrosis factor-a (TNF-a) and vascular endothelial growth factor (VEGF), were measured using multiplex immunoassays. Differences in cytokine levels between groups were assessed. We also investigated correlations between cytokine levels and CT using swept-source optical coherence tomography, as well as an association between plasma cytokine profile and systemic hypertension. Results: We noted differences in IL-6 (p = 0.005), IL-10 (p = 0.03), IL-12 p70 (p = 0.028) and VEGF (p = 0.029) levels between groups. Pro-inflammatory IL12 p70 and multidirectional IL-10 cytokines were upregulated, while proangiogenic VEGF was downregulated in chronic CSC as compared with controls (p = 0.005, p = 0.025 and p = 0.027, respectively). Interleukin-6 (IL-6) was upregulated in acute and chronic CSC (p = 0.030 and p = 0.005, respectively). Interleukin-5 (IL-5), IL-6 and IL-12 levels correlated with mean CT in acute CSC (p = 0.008, p = 0.003 and p = 0.044, respectively), while IL-8, IL-6 and TNF-a plasma levels correlated with hypertension in chronic CSC (p = 0.005, p = 0.033 and p = 0.001, respectively). Conclusion: We provided new evidence for the possible role of plasma cytokines in the pathogenesis of CSC. Our results suggest that IL-6 may be important in the pathophysiology of acute and chronic CSC. The association between inflammatory response and hypertension in patients with CSC was also confirmed.
dc.affiliationpl
Wydział Lekarski : Klinika Okulistyki i Onkologii Okulistycznej
dc.affiliationpl
Wydział Lekarski : Zakład Biologii Molekularnej i Genetyki Klinicznej
dc.cm.date
2021-04-15
dc.cm.id
100481
dc.cm.idOmegapl
UJCMe71d289174bb48008adad77f258bed6c
dc.contributor.authorpl
Karska-Basta, Izabella - 130029
dc.contributor.authorpl
Pociej-Marciak, Weronika - 141644
dc.contributor.authorpl
Chrząszcz, Michał
dc.contributor.authorpl
Kubicka-Trząska, Agnieszka - 130507
dc.contributor.authorpl
Romanowska-Dixon, Bożena - 133294
dc.contributor.authorpl
Sanak, Marek - 133357
dc.date.accessionpl
2021-03-15
dc.date.accessioned
2021-04-29T09:32:05Z
dc.date.available
2021-04-29T09:32:05Z
dc.date.issuedpl
2021
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
2
dc.description.physicalpl
e222-e231
dc.description.points
140
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
99
dc.identifier.doipl
10.1111/aos.14547
dc.identifier.eissnpl
1755-3768
dc.identifier.issnpl
1755-375X
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/270517
dc.identifier.weblink
https://onlinelibrary.wiley.com/doi/full/10.1111/aos.14547
dc.languagepl
eng
dc.language.containerpl
eng
dc.pbn.affiliation
Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.relation.uri*
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
inne
dc.subject.enpl
central serous chorioretinopathy
dc.subject.enpl
choroidal thickness
dc.subject.enpl
cytokines
dc.subject.enpl
hypertension
dc.subject.enpl
inflammation
dc.subject.enpl
interleukins
dc.subtypepl
Article
dc.titlepl
Altered plasma cytokine levels in acute and chronic central serous chorioretinopathy
dc.title.journalpl
Acta Ophthalmologica
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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