Differentiation between radionecrosis and malignant brain tumor recurrence in patients treated by Ir192 HDR brachytherapy : H1-MRS analysis of the brain metabolic spectrum

2005
journal article
article
dc.abstract.enBackground: Computerized tomography (CT) with contrast infusion and Magnetic Resonance Imaging (MRI) do not differentiate radionecrosis and malignant tumor recurrence. Proton Magnetic Resonance Spectroscopy seems to be a new radiological method that could solve this problem. The aim of the study was to evaluate the usability of H1-MRS in patients after brachytherapy. Material/Methods: Sixty patients were treated by Ir 192 HDR brachytherapy because of malignant brain tumors (gliomas and brain metastases). Prospectively, 4 months after brachytherapy, 24 patients underwent MRI and H1-MRS examinations. All patients qualified for the prospective study were in good general condition before and after the brachytherapy (Karnofsky Performance Score (KPS) > 60%). Results: Combined assessment of MRI and H1-MRS gave us the possibility to differentiate the observed pathological changes. In 18 cases (75%) there was a decrease in tumor volume. The tumor infiltration area was larger than the necrotic area in 5 cases. An isolated recurrence mass was observed in only one case. Neurosurgical brain decompression with pathological mass resection was needed in 6 patients with increased intracranial pressure and enhanced neurological deficits. Histopathological examination confirmed the diagnosis revealed in the H1-MRS examination in each case. Conclusions: Proton Magnetic Resonance Spectroscopy is helpful in evaluating the influence of radiation on the tumor and the surrounding brain tissue. Moreover, it solves the problem of differentiating between radionecrosis and tumor recurrence.pl
dc.contributor.authorBarczewska, Monikapl
dc.contributor.authorMaksymowicz, Wojciechpl
dc.contributor.authorWalecki, Jerzypl
dc.contributor.authorŁyczek, Jarosławpl
dc.contributor.authorBeta, Jarosławpl
dc.contributor.authorBulski, Tomaszpl
dc.date.accession2021-02-26pl
dc.date.accessioned2021-02-26T16:52:21Z
dc.date.available2021-02-26T16:52:21Z
dc.date.issued2005pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 26pl
dc.description.number1pl
dc.description.physical22-26pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume70pl
dc.identifier.articleid14763pl
dc.identifier.eissn1899-0967pl
dc.identifier.issn1733-134Xpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/265861
dc.identifier.weblinkhttp://archiwum.inforadiologia.pl/download/index/idArt/14763.htmlpl
dc.languagepolpl
dc.language.containerpolpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enH1-MRSpl
dc.subject.enspectroscopypl
dc.subject.enpost-radiation necrosispl
dc.subject.enbrachytherapypl
dc.subtypeArticlepl
dc.titleDifferentiation between radionecrosis and malignant brain tumor recurrence in patients treated by Ir192 HDR brachytherapy : H1-MRS analysis of the brain metabolic spectrumpl
dc.title.alternativeRóżnicowanie popromiennej martwicy i wznowy złośliwego guza mózgu u pacjentów leczonych przy pomocy brachyterapii Ir 192 metodą HDR w oparciu o analizę spektroskopową widma metabolitów z użyciem H1-MRSpl
dc.title.journalPolish Journal of Radiologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Background: Computerized tomography (CT) with contrast infusion and Magnetic Resonance Imaging (MRI) do not differentiate radionecrosis and malignant tumor recurrence. Proton Magnetic Resonance Spectroscopy seems to be a new radiological method that could solve this problem. The aim of the study was to evaluate the usability of H1-MRS in patients after brachytherapy. Material/Methods: Sixty patients were treated by Ir 192 HDR brachytherapy because of malignant brain tumors (gliomas and brain metastases). Prospectively, 4 months after brachytherapy, 24 patients underwent MRI and H1-MRS examinations. All patients qualified for the prospective study were in good general condition before and after the brachytherapy (Karnofsky Performance Score (KPS) > 60%). Results: Combined assessment of MRI and H1-MRS gave us the possibility to differentiate the observed pathological changes. In 18 cases (75%) there was a decrease in tumor volume. The tumor infiltration area was larger than the necrotic area in 5 cases. An isolated recurrence mass was observed in only one case. Neurosurgical brain decompression with pathological mass resection was needed in 6 patients with increased intracranial pressure and enhanced neurological deficits. Histopathological examination confirmed the diagnosis revealed in the H1-MRS examination in each case. Conclusions: Proton Magnetic Resonance Spectroscopy is helpful in evaluating the influence of radiation on the tumor and the surrounding brain tissue. Moreover, it solves the problem of differentiating between radionecrosis and tumor recurrence.
dc.contributor.authorpl
Barczewska, Monika
dc.contributor.authorpl
Maksymowicz, Wojciech
dc.contributor.authorpl
Walecki, Jerzy
dc.contributor.authorpl
Łyczek, Jarosław
dc.contributor.authorpl
Beta, Jarosław
dc.contributor.authorpl
Bulski, Tomasz
dc.date.accessionpl
2021-02-26
dc.date.accessioned
2021-02-26T16:52:21Z
dc.date.available
2021-02-26T16:52:21Z
dc.date.issuedpl
2005
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 26
dc.description.numberpl
1
dc.description.physicalpl
22-26
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
70
dc.identifier.articleidpl
14763
dc.identifier.eissnpl
1899-0967
dc.identifier.issnpl
1733-134X
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/265861
dc.identifier.weblinkpl
http://archiwum.inforadiologia.pl/download/index/idArt/14763.html
dc.languagepl
pol
dc.language.containerpl
pol
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
H1-MRS
dc.subject.enpl
spectroscopy
dc.subject.enpl
post-radiation necrosis
dc.subject.enpl
brachytherapy
dc.subtypepl
Article
dc.titlepl
Differentiation between radionecrosis and malignant brain tumor recurrence in patients treated by Ir192 HDR brachytherapy : H1-MRS analysis of the brain metabolic spectrum
dc.title.alternativepl
Różnicowanie popromiennej martwicy i wznowy złośliwego guza mózgu u pacjentów leczonych przy pomocy brachyterapii Ir 192 metodą HDR w oparciu o analizę spektroskopową widma metabolitów z użyciem H1-MRS
dc.title.journalpl
Polish Journal of Radiology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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