Ketogenic diet influence on the elemental homeostasis of internal organs is gender dependent

2023
journal article
article
dc.abstract.enThe ketogenic diet (KD) is a low-carbohydrate and high-fat diet that gains increasing popularity in the treatment of numerous diseases, including epilepsy, brain cancers, type 2 diabetes and various metabolic syndromes. Although KD is effective in the treatment of mentioned medical conditions, it is unfortunately not without side effects. The most frequently occurring undesired outcomes of this diet are nutrient deficiencies, the formation of kidney stones, loss of bone mineral density, increased LDL (low-density lipoprotein) cholesterol levels and hormonal disturbances. Both the diet itself and the mentioned adverse effects can influence the elemental composition and homeostasis of internal organs. Therefore, the objective of this study was to determine the elemental abnormalities that appear in the liver, kidney, and spleen of rats subjected to long-term KD treatment. The investigation was conducted separately on males and females to determine if observed changes in the elemental composition of organs are gender-dependent. To measure the concentration of P, S, K, Ca, Fe, Cu, Zn and Se in the tissues the method of the total reflection X-ray fluorescence (TXRF) was utilized. The obtained results revealed numerous elemental abnormalities in the organs of animals fed a high-fat diet. Only some of them can be explained by the differences in the composition and intake of the ketogenic and standard diets. Furthermore, in many cases, the observed anomalies differed between male and female rats.pl
dc.affiliationWydział Biologii : Instytut Zoologii i Badań Biomedycznychpl
dc.contributor.authorKawon, Kamilpl
dc.contributor.authorRugiel, Marzenapl
dc.contributor.authorSetkowicz-Janeczko, Zuzanna - 131836 pl
dc.contributor.authorMatusiak, Katarzynapl
dc.contributor.authorKubala‑Kukus, Aldonapl
dc.contributor.authorStabrawa, Ilonapl
dc.contributor.authorSzary, Karolpl
dc.contributor.authorRauk, Zuzanna - 371268 pl
dc.contributor.authorChwiej, Joannapl
dc.date.accessioned2024-01-23T12:46:30Z
dc.date.available2024-01-23T12:46:30Z
dc.date.issued2023pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalZuzanna Setkowicz-Janeczko podpisana jako Zuzanna Setkowiczpl
dc.description.points140pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume13pl
dc.identifier.articleid18448pl
dc.identifier.doi10.1038/s41598-023-45611-4pl
dc.identifier.eissn2045-2322pl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/325969
dc.languageengpl
dc.language.containerengpl
dc.pbn.affiliationDziedzina nauk ścisłych i przyrodniczych : nauki biologicznepl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subtypeArticlepl
dc.titleKetogenic diet influence on the elemental homeostasis of internal organs is gender dependentpl
dc.title.journalScientific Reportspl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
The ketogenic diet (KD) is a low-carbohydrate and high-fat diet that gains increasing popularity in the treatment of numerous diseases, including epilepsy, brain cancers, type 2 diabetes and various metabolic syndromes. Although KD is effective in the treatment of mentioned medical conditions, it is unfortunately not without side effects. The most frequently occurring undesired outcomes of this diet are nutrient deficiencies, the formation of kidney stones, loss of bone mineral density, increased LDL (low-density lipoprotein) cholesterol levels and hormonal disturbances. Both the diet itself and the mentioned adverse effects can influence the elemental composition and homeostasis of internal organs. Therefore, the objective of this study was to determine the elemental abnormalities that appear in the liver, kidney, and spleen of rats subjected to long-term KD treatment. The investigation was conducted separately on males and females to determine if observed changes in the elemental composition of organs are gender-dependent. To measure the concentration of P, S, K, Ca, Fe, Cu, Zn and Se in the tissues the method of the total reflection X-ray fluorescence (TXRF) was utilized. The obtained results revealed numerous elemental abnormalities in the organs of animals fed a high-fat diet. Only some of them can be explained by the differences in the composition and intake of the ketogenic and standard diets. Furthermore, in many cases, the observed anomalies differed between male and female rats.
dc.affiliationpl
Wydział Biologii : Instytut Zoologii i Badań Biomedycznych
dc.contributor.authorpl
Kawon, Kamil
dc.contributor.authorpl
Rugiel, Marzena
dc.contributor.authorpl
Setkowicz-Janeczko, Zuzanna - 131836
dc.contributor.authorpl
Matusiak, Katarzyna
dc.contributor.authorpl
Kubala‑Kukus, Aldona
dc.contributor.authorpl
Stabrawa, Ilona
dc.contributor.authorpl
Szary, Karol
dc.contributor.authorpl
Rauk, Zuzanna - 371268
dc.contributor.authorpl
Chwiej, Joanna
dc.date.accessioned
2024-01-23T12:46:30Z
dc.date.available
2024-01-23T12:46:30Z
dc.date.issuedpl
2023
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Zuzanna Setkowicz-Janeczko podpisana jako Zuzanna Setkowicz
dc.description.pointspl
140
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
13
dc.identifier.articleidpl
18448
dc.identifier.doipl
10.1038/s41598-023-45611-4
dc.identifier.eissnpl
2045-2322
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/325969
dc.languagepl
eng
dc.language.containerpl
eng
dc.pbn.affiliationpl
Dziedzina nauk ścisłych i przyrodniczych : nauki biologiczne
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subtypepl
Article
dc.titlepl
Ketogenic diet influence on the elemental homeostasis of internal organs is gender dependent
dc.title.journalpl
Scientific Reports
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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