Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 A1166C and AGTR2 G1675A gene polymorphisms

2016
journal article
article
cris.lastimport.wos2024-04-10T00:27:24Z
dc.abstract.enIntroduction: Although recently a matter of epidemiologic controversy, sodium overload and its interaction with genetic factors predispose to hypertension and related target organ complications. Methods: In 131 (66 male) treated hypertensives, we measured peripheral and central arterial pressures and pulse wave augmentation indexes ($AIx_{\rho}$, $AIx_{C1}$, $AIx_{C2}$), pulse wave velocity (PWV), daily urinary sodium excretion and did genetic studies of AGTR1 A1166C and AGTR2 G1675A polymorphisms. Proximal ($FE_{L1}$) and distal ($FDR_{Na}$) sodium reabsorption measurements were performed using endogenous lithium clearance. Results: In men, we found interaction between $FDR_{Na}$ and AGTR2 G1675A polymorphism with respect to $Alx_{C1}$ ($\rho _{INT}$=0.01), $Alx_{C2}$ ($\rho _{INT}$=0.05) and $Alx_{\rho}$ ($\rho _{INT}$=0.006). Arterial stiffness increased with higher sodium reabsorption in the distal tubule, in the presence of AGTR2 G allele with the opposite tendency in A allele carriers. In the subgroup with $FDR_{Na}$ below median, as compared to those with $FDR_{Na}$ above median, the $Alx_{C1}$ (139.6±3.8 vs 159.1±5.7%; $\rho$=0.009), $Alx_{C2}$ (26.3±1.8 vs 33.3±1.7%; $\rho$=0.016) and $Alx_{\rho}$ (83.4±2.5 vs 96.5±2.6%; $\rho$<0.0001) were lower, in the G allele carrying men and GG homozygous women. Conclusions: The relation between sodium reabsorption in the distal tubule and the development of arterial stiffness depends on the AGTR2 G1675A polymorphism in blood pressure independent fashion.pl
dc.affiliationWydział Farmaceutyczny : Zakład Bromatologiipl
dc.affiliationWydział Lekarski : Klinika Chorób Wewnętrznych i Geriatriipl
dc.affiliationWydział Lekarski : Zakład Neurogenetykipl
dc.cm.date2020-01-07
dc.cm.id78294
dc.contributor.authorCwynar, Marcin - 129078 pl
dc.contributor.authorGąsowski, Jerzy - 129477 pl
dc.contributor.authorGłuszewska, Anna - 141391 pl
dc.contributor.authorKrólczyk, Jarosław - 214057 pl
dc.contributor.authorBartoń, Henryk - 128680 pl
dc.contributor.authorSłowik, Agnieszka - 133430 pl
dc.contributor.authorGrodzicki, Tomasz - 129614 pl
dc.date.accessioned2020-01-17T09:09:05Z
dc.date.available2020-01-17T09:09:05Z
dc.date.issued2016pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number2pl
dc.description.points20pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume17pl
dc.identifier.articleid1470320316655669pl
dc.identifier.doi10.1177/1470320316655669pl
dc.identifier.eissn1752-8976pl
dc.identifier.issn1470-3203pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/138195
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 3.0*
dc.rights.licenceCC-BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/legalcode*
dc.share.typeotwarte czasopismo
dc.subject.enhypertensionpl
dc.subject.enarterial stiffnesspl
dc.subject.endistal sodium reabsorptionpl
dc.subject.enAGTR2 G1675Apl
dc.subtypeArticlepl
dc.titleBlood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 A1166C and AGTR2 G1675A gene polymorphismspl
dc.title.journalJRAAS. Journal of the Renin-Angiotensin-Aldosterone Systempl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T00:27:24Z
dc.abstract.enpl
Introduction: Although recently a matter of epidemiologic controversy, sodium overload and its interaction with genetic factors predispose to hypertension and related target organ complications. Methods: In 131 (66 male) treated hypertensives, we measured peripheral and central arterial pressures and pulse wave augmentation indexes ($AIx_{\rho}$, $AIx_{C1}$, $AIx_{C2}$), pulse wave velocity (PWV), daily urinary sodium excretion and did genetic studies of AGTR1 A1166C and AGTR2 G1675A polymorphisms. Proximal ($FE_{L1}$) and distal ($FDR_{Na}$) sodium reabsorption measurements were performed using endogenous lithium clearance. Results: In men, we found interaction between $FDR_{Na}$ and AGTR2 G1675A polymorphism with respect to $Alx_{C1}$ ($\rho _{INT}$=0.01), $Alx_{C2}$ ($\rho _{INT}$=0.05) and $Alx_{\rho}$ ($\rho _{INT}$=0.006). Arterial stiffness increased with higher sodium reabsorption in the distal tubule, in the presence of AGTR2 G allele with the opposite tendency in A allele carriers. In the subgroup with $FDR_{Na}$ below median, as compared to those with $FDR_{Na}$ above median, the $Alx_{C1}$ (139.6±3.8 vs 159.1±5.7%; $\rho$=0.009), $Alx_{C2}$ (26.3±1.8 vs 33.3±1.7%; $\rho$=0.016) and $Alx_{\rho}$ (83.4±2.5 vs 96.5±2.6%; $\rho$<0.0001) were lower, in the G allele carrying men and GG homozygous women. Conclusions: The relation between sodium reabsorption in the distal tubule and the development of arterial stiffness depends on the AGTR2 G1675A polymorphism in blood pressure independent fashion.
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Bromatologii
dc.affiliationpl
Wydział Lekarski : Klinika Chorób Wewnętrznych i Geriatrii
dc.affiliationpl
Wydział Lekarski : Zakład Neurogenetyki
dc.cm.date
2020-01-07
dc.cm.id
78294
dc.contributor.authorpl
Cwynar, Marcin - 129078
dc.contributor.authorpl
Gąsowski, Jerzy - 129477
dc.contributor.authorpl
Głuszewska, Anna - 141391
dc.contributor.authorpl
Królczyk, Jarosław - 214057
dc.contributor.authorpl
Bartoń, Henryk - 128680
dc.contributor.authorpl
Słowik, Agnieszka - 133430
dc.contributor.authorpl
Grodzicki, Tomasz - 129614
dc.date.accessioned
2020-01-17T09:09:05Z
dc.date.available
2020-01-17T09:09:05Z
dc.date.issuedpl
2016
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
2
dc.description.pointspl
20
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
17
dc.identifier.articleidpl
1470320316655669
dc.identifier.doipl
10.1177/1470320316655669
dc.identifier.eissnpl
1752-8976
dc.identifier.issnpl
1470-3203
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/138195
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 3.0
dc.rights.licence
CC-BY-NC
dc.rights.uri*
http://creativecommons.org/licenses/by-nc/3.0/legalcode
dc.share.type
otwarte czasopismo
dc.subject.enpl
hypertension
dc.subject.enpl
arterial stiffness
dc.subject.enpl
distal sodium reabsorption
dc.subject.enpl
AGTR2 G1675A
dc.subtypepl
Article
dc.titlepl
Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 A1166C and AGTR2 G1675A gene polymorphisms
dc.title.journalpl
JRAAS. Journal of the Renin-Angiotensin-Aldosterone System
dc.typepl
JournalArticle
dspace.entity.type
Publication

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