Long term patterns of association between MHC and helminth burdens in the bank vole support Red Queen dynamics

2022
journal article
article
cris.lastimport.wos2024-04-10T00:34:16Z
dc.abstract.enMajor histocompatibility complex (MHC) genes encode proteins crucial for adaptive immunity of vertebrates. Negative frequency- dependent selection (NFDS), result- ing from adaptation of parasites to common MHC types, has been hypothesized to maintain high, functionally relevant polymorphism of MHC, but demonstration of this relationship has remained elusive. In particular, differentiation of NFDS from fluctuat- ing selection, resulting from changes in parasite communities in time and space (FS), has proved difficult in short- term studies. Here, we used temporal data, accumulated through long- term monitoring of helminths infecting bank voles (Myodes glareolus), to test specific predictions of NFDS on MHC class II. Data were collected in three, mod- erately genetically differentiated subpopulations in Poland, which were characterized by some stable spatiotemporal helminth communities but also events indicating intro- duction of new species and loss of others. We found a complex association between individual MHC diversity and species richness, where intermediate numbers of DRB supertypes correlated with lowest species richness, but the opposite was true for DQB supertypes - arguing against universal selection for immunogenetic optimality. We also showed that particular MHC supertypes explain a portion of the variance in prevalence and abundance of helminths, but this effect was subpopulation- specific, which is consistent with both NFDS and FS. Finally, in line with NFDS, we found that certain helminths that have recently colonized or spread in a given subpopulation, more frequently or intensely infected voles with MHC supertypes that have been common in the recent past. Overall, our results highlight complex spatial and temporal patterns of MHC- parasite associations, the latter being consistent with Red Queen coevolutionary dynamics.pl
dc.affiliationWydział Biologii : Instytut Nauk o Środowiskupl
dc.contributor.authorMigalska, Magdalena - 165787 pl
dc.contributor.authorPrzesmycka, Karolinapl
dc.contributor.authorAlsarraf, Mohammedpl
dc.contributor.authorBajer, Annapl
dc.contributor.authorBehnke-Borowczyk, Jolantapl
dc.contributor.authorGrzybek, Maciejpl
dc.contributor.authorBehnke, Jerzypl
dc.contributor.authorRadwan, Jacekpl
dc.date.accessioned2023-02-07T09:23:53Z
dc.date.available2023-02-07T09:23:53Z
dc.date.issued2022pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number12pl
dc.description.physical3400-3415pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume31pl
dc.identifier.doi10.1111/mec.16486pl
dc.identifier.eissn1365-294Xpl
dc.identifier.issn0962-1083pl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/307377
dc.languageengpl
dc.language.containerengpl
dc.pbn.affiliationDziedzina nauk ścisłych i przyrodniczych : nauki biologicznepl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeinne
dc.subject.enmajor histocompatibility complexpl
dc.subject.enMyodes glareoluspl
dc.subject.ennegative frequency-dependent selectionpl
dc.subject.enRed Queenpl
dc.subtypeArticlepl
dc.titleLong term patterns of association between MHC and helminth burdens in the bank vole support Red Queen dynamicspl
dc.title.journalMolecular Ecologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T00:34:16Z
dc.abstract.enpl
Major histocompatibility complex (MHC) genes encode proteins crucial for adaptive immunity of vertebrates. Negative frequency- dependent selection (NFDS), result- ing from adaptation of parasites to common MHC types, has been hypothesized to maintain high, functionally relevant polymorphism of MHC, but demonstration of this relationship has remained elusive. In particular, differentiation of NFDS from fluctuat- ing selection, resulting from changes in parasite communities in time and space (FS), has proved difficult in short- term studies. Here, we used temporal data, accumulated through long- term monitoring of helminths infecting bank voles (Myodes glareolus), to test specific predictions of NFDS on MHC class II. Data were collected in three, mod- erately genetically differentiated subpopulations in Poland, which were characterized by some stable spatiotemporal helminth communities but also events indicating intro- duction of new species and loss of others. We found a complex association between individual MHC diversity and species richness, where intermediate numbers of DRB supertypes correlated with lowest species richness, but the opposite was true for DQB supertypes - arguing against universal selection for immunogenetic optimality. We also showed that particular MHC supertypes explain a portion of the variance in prevalence and abundance of helminths, but this effect was subpopulation- specific, which is consistent with both NFDS and FS. Finally, in line with NFDS, we found that certain helminths that have recently colonized or spread in a given subpopulation, more frequently or intensely infected voles with MHC supertypes that have been common in the recent past. Overall, our results highlight complex spatial and temporal patterns of MHC- parasite associations, the latter being consistent with Red Queen coevolutionary dynamics.
dc.affiliationpl
Wydział Biologii : Instytut Nauk o Środowisku
dc.contributor.authorpl
Migalska, Magdalena - 165787
dc.contributor.authorpl
Przesmycka, Karolina
dc.contributor.authorpl
Alsarraf, Mohammed
dc.contributor.authorpl
Bajer, Anna
dc.contributor.authorpl
Behnke-Borowczyk, Jolanta
dc.contributor.authorpl
Grzybek, Maciej
dc.contributor.authorpl
Behnke, Jerzy
dc.contributor.authorpl
Radwan, Jacek
dc.date.accessioned
2023-02-07T09:23:53Z
dc.date.available
2023-02-07T09:23:53Z
dc.date.issuedpl
2022
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
12
dc.description.physicalpl
3400-3415
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
31
dc.identifier.doipl
10.1111/mec.16486
dc.identifier.eissnpl
1365-294X
dc.identifier.issnpl
0962-1083
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/307377
dc.languagepl
eng
dc.language.containerpl
eng
dc.pbn.affiliationpl
Dziedzina nauk ścisłych i przyrodniczych : nauki biologiczne
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
inne
dc.subject.enpl
major histocompatibility complex
dc.subject.enpl
Myodes glareolus
dc.subject.enpl
negative frequency-dependent selection
dc.subject.enpl
Red Queen
dc.subtypepl
Article
dc.titlepl
Long term patterns of association between MHC and helminth burdens in the bank vole support Red Queen dynamics
dc.title.journalpl
Molecular Ecology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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