Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects : a randomized placebo controlled trial

2015
journal article
article
20
dc.abstract.enBackground: Caloric restriction and n-3 polyunsaturated fatty acid (PUFA) supplementation protect fromsome of themetabolic complications. The aim of this study was to assess the influence of a low calorie diet with or without n-3 PUFA supplementation on glucose dependent insulinotropic polypeptide (GIP) output and insulin sensitivity markers in obese subjects. Methods: Obese, non-diabetic subjects (BMI $30-40 kg/m^{2}$) and aged 25-65 yr. were put on low calorie diet (1200-1500 kcal/day) supplemented with either 1.8 g/day n-3 PUFA (DHA/EPA, 5:1) (n=24) or placebo capsules (n= 24) for three months in a randomized placebo controlled trial. Insulin resistance markers and GIP levels were analysed from samples obtained at fasting and during an oral glucose tolerance test (OGTT). Results: Caloric restriction with n-3 PUFA led to a decrease of insulin resistance index (HOMA-IR) and a significant reduction of insulin output as well as decreased GIP secretion during the OGTT. These effects were not seen with caloric restriction alone. Changes in GIP output were inversely associatedwith changes in red blood cell EPA content whereas fasting GIP level positively correlatedwith HOMA-IR index. Blood triglyceride levelwas lowered by caloric restriction with a greater effect when n-3 PUFA were included and correlated positively with fasting GIP level. Conclusions: Three months of caloric restriction with DHA + EPA supplementation exerts beneficial effects on insulin resistance, GIP and triglycerides. General significance: Combining caloric restriction and n-3 PUFA improves insulin sensitivity, whichmay be related to a decrease of GIP levels.pl
dc.affiliationWydział Lekarski : Zakład Biochemii Klinicznejpl
dc.affiliationWydział Lekarski : Klinika Chorób Metabolicznychpl
dc.affiliationWydział Lekarski : Zakład Diagnostyki Genetycznej i Nutrigenomikipl
dc.affiliationWydział Lekarski : Zakład Diagnostykipl
dc.cm.date2020-01-07
dc.cm.id77751
dc.contributor.authorRaźny, Urszula - 133265 pl
dc.contributor.authorKieć-Wilk, Beata - 130090 pl
dc.contributor.authorPolus, Anna - 133199 pl
dc.contributor.authorGóralska, Joanna - 129579 pl
dc.contributor.authorMalczewska-Malec, Małgorzata - 130821 pl
dc.contributor.authorWnek, Dominikapl
dc.contributor.authorZdzienicka, Anna - 133912 pl
dc.contributor.authorGruca, Anna - 129624 pl
dc.contributor.authorChilds, Caroline E.pl
dc.contributor.authorKapusta, Maria - 130011 pl
dc.contributor.authorSłowińska-Solnica, Krystyna - 133433 pl
dc.contributor.authorCalder, Philip C.pl
dc.contributor.authorDembińska-Kieć, Aldona - 129163 pl
dc.date.accessioned2020-01-17T09:04:05Z
dc.date.available2020-01-17T09:04:05Z
dc.date.issued2015pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.physical7-13pl
dc.description.points5pl
dc.description.publication1,24pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume4pl
dc.identifier.doi10.1016/j.bbacli.2015.05.001pl
dc.identifier.eissn2214-6474
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/137884
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enn-3 polyunsaturated fatty acidspl
dc.subject.endocosahexaenoic acidpl
dc.subject.eneicosapentaenoic acidpl
dc.subject.encaloric restrictionpl
dc.subject.eninsulin resistancepl
dc.subject.enobesitypl
dc.subtypeArticlepl
dc.titleEffect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects : a randomized placebo controlled trialpl
dc.title.journalBBA Clinicalpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Background: Caloric restriction and n-3 polyunsaturated fatty acid (PUFA) supplementation protect fromsome of themetabolic complications. The aim of this study was to assess the influence of a low calorie diet with or without n-3 PUFA supplementation on glucose dependent insulinotropic polypeptide (GIP) output and insulin sensitivity markers in obese subjects. Methods: Obese, non-diabetic subjects (BMI $30-40 kg/m^{2}$) and aged 25-65 yr. were put on low calorie diet (1200-1500 kcal/day) supplemented with either 1.8 g/day n-3 PUFA (DHA/EPA, 5:1) (n=24) or placebo capsules (n= 24) for three months in a randomized placebo controlled trial. Insulin resistance markers and GIP levels were analysed from samples obtained at fasting and during an oral glucose tolerance test (OGTT). Results: Caloric restriction with n-3 PUFA led to a decrease of insulin resistance index (HOMA-IR) and a significant reduction of insulin output as well as decreased GIP secretion during the OGTT. These effects were not seen with caloric restriction alone. Changes in GIP output were inversely associatedwith changes in red blood cell EPA content whereas fasting GIP level positively correlatedwith HOMA-IR index. Blood triglyceride levelwas lowered by caloric restriction with a greater effect when n-3 PUFA were included and correlated positively with fasting GIP level. Conclusions: Three months of caloric restriction with DHA + EPA supplementation exerts beneficial effects on insulin resistance, GIP and triglycerides. General significance: Combining caloric restriction and n-3 PUFA improves insulin sensitivity, whichmay be related to a decrease of GIP levels.
dc.affiliationpl
Wydział Lekarski : Zakład Biochemii Klinicznej
dc.affiliationpl
Wydział Lekarski : Klinika Chorób Metabolicznych
dc.affiliationpl
Wydział Lekarski : Zakład Diagnostyki Genetycznej i Nutrigenomiki
dc.affiliationpl
Wydział Lekarski : Zakład Diagnostyki
dc.cm.date
2020-01-07
dc.cm.id
77751
dc.contributor.authorpl
Raźny, Urszula - 133265
dc.contributor.authorpl
Kieć-Wilk, Beata - 130090
dc.contributor.authorpl
Polus, Anna - 133199
dc.contributor.authorpl
Góralska, Joanna - 129579
dc.contributor.authorpl
Malczewska-Malec, Małgorzata - 130821
dc.contributor.authorpl
Wnek, Dominika
dc.contributor.authorpl
Zdzienicka, Anna - 133912
dc.contributor.authorpl
Gruca, Anna - 129624
dc.contributor.authorpl
Childs, Caroline E.
dc.contributor.authorpl
Kapusta, Maria - 130011
dc.contributor.authorpl
Słowińska-Solnica, Krystyna - 133433
dc.contributor.authorpl
Calder, Philip C.
dc.contributor.authorpl
Dembińska-Kieć, Aldona - 129163
dc.date.accessioned
2020-01-17T09:04:05Z
dc.date.available
2020-01-17T09:04:05Z
dc.date.issuedpl
2015
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.physicalpl
7-13
dc.description.pointspl
5
dc.description.publicationpl
1,24
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
4
dc.identifier.doipl
10.1016/j.bbacli.2015.05.001
dc.identifier.eissn
2214-6474
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/137884
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
n-3 polyunsaturated fatty acids
dc.subject.enpl
docosahexaenoic acid
dc.subject.enpl
eicosapentaenoic acid
dc.subject.enpl
caloric restriction
dc.subject.enpl
insulin resistance
dc.subject.enpl
obesity
dc.subtypepl
Article
dc.titlepl
Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects : a randomized placebo controlled trial
dc.title.journalpl
BBA Clinical
dc.typepl
JournalArticle
dspace.entity.type
Publication

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