Raman spectroscopy and the material study of nanocomposite membranes from poly(ε-caprolactone) with biocompatibility testing in osteoblast-like cells

2015
journal article
article
39
dc.abstract.enModern medical treatment can be improved by nanotechnology methods for preparing nanocomposites with novel physical, chemical and biological properties. The materials studied and analysed as membranes were produced from poly(ε-caprolactone) (PCL), which contained identical amounts of nano-additives, either montmorillonite (MMT) or functionalized multi-walled carbon nanotubes (MWCNT-f), while the reference membranes were obtained from unmodified PCL. In addition to the conventional methods used in the study of materials for medical purposes such as DSC, contact angle measurements, surface topography, Raman spectroscopy was also applied. Raman microspectroscopy can decode the phenomenon that occurs in the polymer in contact with the nanoparticles. Besides identifying the vibrations of certain functional groups, the calculation of crystallinity parameters is also possible, by which the most intense interactions within the nanocomposites can be analysed. The Raman studies indicate that each of the nano-additives reacts differently with the polymer matrix, which results in material properties that influence its biological properties. MWCNT-f interacts preferentially with the oxygen-containing groups, and particularly with the backbone regions in the vicinity of the single CO bond. The human osteoblast-like MG-63 cells, cultured on the PCL/MWCNT-f membrane for three days, show almost 100% viability.pl
dc.affiliationPion Prorektora ds. badań naukowych i funduszy strukturalnych : Centrum Transferu Technologii CITTRUpl
dc.affiliationWydział Chemii : Zakład Fizyki Chemicznejpl
dc.contributor.authorWesełucha-Birczyńska, Aleksandra - 132583 pl
dc.contributor.authorŚwiętek, Małgorzatapl
dc.contributor.authorSołtysiak, Elżbietapl
dc.contributor.authorGaliński, Piotrpl
dc.contributor.authorPłachta, Łukaszpl
dc.contributor.authorPiekara, Katarzynapl
dc.contributor.authorBłażewicz, M.pl
dc.date.accessioned2015-07-02T08:00:25Z
dc.date.available2015-07-02T08:00:25Z
dc.date.issued2015pl
dc.description.admin[AB] Galiński, Piotr 50000141pl
dc.description.admin[AB] Płachta, Łukasz 50000141pl
dc.description.admin[AB] Piekara, Katarzyna 50000141pl
dc.description.number7pl
dc.description.physical2311-2320pl
dc.description.volume140pl
dc.identifier.doi10.1039/C4AN02284Jpl
dc.identifier.eissn1364-5528pl
dc.identifier.issn0003-2654pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/11125
dc.languageengpl
dc.language.containerengpl
dc.rights.licencebez licencji
dc.subtypeArticlepl
dc.titleRaman spectroscopy and the material study of nanocomposite membranes from poly(ε-caprolactone) with biocompatibility testing in osteoblast-like cellspl
dc.title.journalAnalystpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Modern medical treatment can be improved by nanotechnology methods for preparing nanocomposites with novel physical, chemical and biological properties. The materials studied and analysed as membranes were produced from poly(ε-caprolactone) (PCL), which contained identical amounts of nano-additives, either montmorillonite (MMT) or functionalized multi-walled carbon nanotubes (MWCNT-f), while the reference membranes were obtained from unmodified PCL. In addition to the conventional methods used in the study of materials for medical purposes such as DSC, contact angle measurements, surface topography, Raman spectroscopy was also applied. Raman microspectroscopy can decode the phenomenon that occurs in the polymer in contact with the nanoparticles. Besides identifying the vibrations of certain functional groups, the calculation of crystallinity parameters is also possible, by which the most intense interactions within the nanocomposites can be analysed. The Raman studies indicate that each of the nano-additives reacts differently with the polymer matrix, which results in material properties that influence its biological properties. MWCNT-f interacts preferentially with the oxygen-containing groups, and particularly with the backbone regions in the vicinity of the single CO bond. The human osteoblast-like MG-63 cells, cultured on the PCL/MWCNT-f membrane for three days, show almost 100% viability.
dc.affiliationpl
Pion Prorektora ds. badań naukowych i funduszy strukturalnych : Centrum Transferu Technologii CITTRU
dc.affiliationpl
Wydział Chemii : Zakład Fizyki Chemicznej
dc.contributor.authorpl
Wesełucha-Birczyńska, Aleksandra - 132583
dc.contributor.authorpl
Świętek, Małgorzata
dc.contributor.authorpl
Sołtysiak, Elżbieta
dc.contributor.authorpl
Galiński, Piotr
dc.contributor.authorpl
Płachta, Łukasz
dc.contributor.authorpl
Piekara, Katarzyna
dc.contributor.authorpl
Błażewicz, M.
dc.date.accessioned
2015-07-02T08:00:25Z
dc.date.available
2015-07-02T08:00:25Z
dc.date.issuedpl
2015
dc.description.adminpl
[AB] Galiński, Piotr 50000141
dc.description.adminpl
[AB] Płachta, Łukasz 50000141
dc.description.adminpl
[AB] Piekara, Katarzyna 50000141
dc.description.numberpl
7
dc.description.physicalpl
2311-2320
dc.description.volumepl
140
dc.identifier.doipl
10.1039/C4AN02284J
dc.identifier.eissnpl
1364-5528
dc.identifier.issnpl
0003-2654
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/11125
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights.licence
bez licencji
dc.subtypepl
Article
dc.titlepl
Raman spectroscopy and the material study of nanocomposite membranes from poly(ε-caprolactone) with biocompatibility testing in osteoblast-like cells
dc.title.journalpl
Analyst
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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