New arginine substituted derivative of poly(allylamine hydrochloride) for heparin reversal

2014
journal article
article
16
dc.abstract.enNew derivatives of polyallylamine containing arginine moieties (PAH-ARG) were synthesized. The in vitro tests performed in heparinized blood plasma showed that the complexation of heparin by PAH-ARG polymers allowed the reduction of the activated partial thromboplastin time (aPTT) values to the normal level. The dose of PAH-ARG required for complete reversal of aPTT (prolonged by 1 U of heparin) was half of that required for protamine sulfate, the currently used heparin antagonist. The efficacy of these polymers in the neutralization of heparin was confirmed by in vivo tests using a rat model. PAH-ARG polymers were nontoxic to the fibroblast cells.pl
dc.affiliationWydział Chemii : Zakład Chemii Fizycznej i Elektrochemiipl
dc.affiliationWydział Biochemii, Biofizyki i Biotechnologii : Zakład Biologii Komórkipl
dc.affiliationWydział Farmaceutyczny : Zakład Biochemii Farmaceutycznejpl
dc.contributor.authorKamiński, Kamil - 126126 pl
dc.contributor.authorKałaska, Bartłomiejpl
dc.contributor.authorKoczurkiewicz, Paulina - 114120 pl
dc.contributor.authorMichalik, Marta - 130517 pl
dc.contributor.authorSzczubiałka, Krzysztof - 132218 pl
dc.contributor.authorMogielnicki, Andrzejpl
dc.contributor.authorBuczko, Włodzimierzpl
dc.contributor.authorNowakowska, Maria - 131048 pl
dc.date.accessioned2015-01-15T11:08:08Z
dc.date.available2015-01-15T11:08:08Z
dc.date.issued2014pl
dc.description.number4pl
dc.description.physical489-495pl
dc.description.volume5pl
dc.identifier.doi10.1039/c3md00374dpl
dc.identifier.eissn2040-2511pl
dc.identifier.issn2040-2503pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/2565
dc.languageengpl
dc.language.containerengpl
dc.rights.licencebez licencji
dc.subtypeArticlepl
dc.titleNew arginine substituted derivative of poly(allylamine hydrochloride) for heparin reversalpl
dc.title.journalMedChemCommpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
New derivatives of polyallylamine containing arginine moieties (PAH-ARG) were synthesized. The in vitro tests performed in heparinized blood plasma showed that the complexation of heparin by PAH-ARG polymers allowed the reduction of the activated partial thromboplastin time (aPTT) values to the normal level. The dose of PAH-ARG required for complete reversal of aPTT (prolonged by 1 U of heparin) was half of that required for protamine sulfate, the currently used heparin antagonist. The efficacy of these polymers in the neutralization of heparin was confirmed by in vivo tests using a rat model. PAH-ARG polymers were nontoxic to the fibroblast cells.
dc.affiliationpl
Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii
dc.affiliationpl
Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biologii Komórki
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Biochemii Farmaceutycznej
dc.contributor.authorpl
Kamiński, Kamil - 126126
dc.contributor.authorpl
Kałaska, Bartłomiej
dc.contributor.authorpl
Koczurkiewicz, Paulina - 114120
dc.contributor.authorpl
Michalik, Marta - 130517
dc.contributor.authorpl
Szczubiałka, Krzysztof - 132218
dc.contributor.authorpl
Mogielnicki, Andrzej
dc.contributor.authorpl
Buczko, Włodzimierz
dc.contributor.authorpl
Nowakowska, Maria - 131048
dc.date.accessioned
2015-01-15T11:08:08Z
dc.date.available
2015-01-15T11:08:08Z
dc.date.issuedpl
2014
dc.description.numberpl
4
dc.description.physicalpl
489-495
dc.description.volumepl
5
dc.identifier.doipl
10.1039/c3md00374d
dc.identifier.eissnpl
2040-2511
dc.identifier.issnpl
2040-2503
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/2565
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights.licence
bez licencji
dc.subtypepl
Article
dc.titlepl
New arginine substituted derivative of poly(allylamine hydrochloride) for heparin reversal
dc.title.journalpl
MedChemComm
dc.typepl
JournalArticle
dspace.entity.type
Publication

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