Stability of Metronidazole and Its Complexes with Silver(I) Salts under Various Stress Conditions

2021
journal article
article
10
dc.abstract.enMetronidazole is a drug widely used in the prevention and treatment of bacterial infections. Due to its possibility of the formation of stable metal complexes, it was decided to broaden its activity spectrum by introducing the silver(I) coordination compounds i.e., [Ag(MTZ)2NO3] and [(Ag(MTZ)2)2]SO4, which have significant antibacterial properties. The paper presents a description of a new qualitative and quantitative analysis of metronidazole in bulk and possible pharmaceutical preparations by thin-layer chromatography with densitometric detection. Optimal separation conditions were selected, and the analytical procedure was validated according to the ICH guidelines. The obtained data indicate that the method is sufficiently sensitive, precise, and accurate. The stability of the metronidazole solutions obtained from tablets, pure metronidazole, and its silver(I) complexes was tested. The research was carried out in various environments, at different temperatures, in H2O2 solution, and during exposure to radiation (UV, sunlight). The greatest degradation was found in the alkaline environment and at higher temperatures. The silver(I) complexes exhibited relatively high stability under analyzed conditions that are higher than standard metronidazole solutions and tablets. The observations were confirmed by the kinetic and thermodynamic analysis. The described studies of new metronidazole silver(I) complexes increase the potential for their application in infections both in humans and animals.pl
dc.affiliationWydział Farmaceutyczny : Zakład Chemii Nieorganicznejpl
dc.cm.id105046
dc.cm.idOmegaUJCMe5d15535d86b49548baf34fbd4170c1cpl
dc.contributor.authorStarek, Małgorzata - 133481 pl
dc.contributor.authorDąbrowska, Monika - 129159 pl
dc.contributor.authorChebda, Joannapl
dc.contributor.authorŻyro, Dominikpl
dc.contributor.authorOchocki, Justynpl
dc.date.accession2022-02-01pl
dc.date.accessioned2021-11-08T09:33:46Z
dc.date.available2021-11-08T09:33:46Z
dc.date.issued2021pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number12pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume26pl
dc.identifier.articleid3582pl
dc.identifier.doi10.3390/molecules26123582pl
dc.identifier.eissn1420-3049pl
dc.identifier.issn1420-3049pl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/283065
dc.identifier.weblinkhttps://www.mdpi.com/1420-3049/26/12/3582pl
dc.languageengpl
dc.language.containerengpl
dc.pbn.affiliationDziedzina nauk medycznych i nauk o zdrowiu : nauki farmaceutyczne
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licenceCC-BY
dc.rights.uri*
dc.share.typeOtwarte czasopismo
dc.subject.enmetronidazolepl
dc.subject.enTLC-densitometrypl
dc.subject.envalidation of the methodpl
dc.subject.enstability testingpl
dc.subject.ensilver(I) complexpl
dc.subtypeArticlepl
dc.titleStability of Metronidazole and Its Complexes with Silver(I) Salts under Various Stress Conditionspl
dc.title.journalMoleculespl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Metronidazole is a drug widely used in the prevention and treatment of bacterial infections. Due to its possibility of the formation of stable metal complexes, it was decided to broaden its activity spectrum by introducing the silver(I) coordination compounds i.e., [Ag(MTZ)2NO3] and [(Ag(MTZ)2)2]SO4, which have significant antibacterial properties. The paper presents a description of a new qualitative and quantitative analysis of metronidazole in bulk and possible pharmaceutical preparations by thin-layer chromatography with densitometric detection. Optimal separation conditions were selected, and the analytical procedure was validated according to the ICH guidelines. The obtained data indicate that the method is sufficiently sensitive, precise, and accurate. The stability of the metronidazole solutions obtained from tablets, pure metronidazole, and its silver(I) complexes was tested. The research was carried out in various environments, at different temperatures, in H2O2 solution, and during exposure to radiation (UV, sunlight). The greatest degradation was found in the alkaline environment and at higher temperatures. The silver(I) complexes exhibited relatively high stability under analyzed conditions that are higher than standard metronidazole solutions and tablets. The observations were confirmed by the kinetic and thermodynamic analysis. The described studies of new metronidazole silver(I) complexes increase the potential for their application in infections both in humans and animals.
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Chemii Nieorganicznej
dc.cm.id
105046
dc.cm.idOmegapl
UJCMe5d15535d86b49548baf34fbd4170c1c
dc.contributor.authorpl
Starek, Małgorzata - 133481
dc.contributor.authorpl
Dąbrowska, Monika - 129159
dc.contributor.authorpl
Chebda, Joanna
dc.contributor.authorpl
Żyro, Dominik
dc.contributor.authorpl
Ochocki, Justyn
dc.date.accessionpl
2022-02-01
dc.date.accessioned
2021-11-08T09:33:46Z
dc.date.available
2021-11-08T09:33:46Z
dc.date.issuedpl
2021
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
12
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
26
dc.identifier.articleidpl
3582
dc.identifier.doipl
10.3390/molecules26123582
dc.identifier.eissnpl
1420-3049
dc.identifier.issnpl
1420-3049
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/283065
dc.identifier.weblinkpl
https://www.mdpi.com/1420-3049/26/12/3582
dc.languagepl
eng
dc.language.containerpl
eng
dc.pbn.affiliation
Dziedzina nauk medycznych i nauk o zdrowiu : nauki farmaceutyczne
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
CC-BY
dc.rights.uri*
dc.share.type
Otwarte czasopismo
dc.subject.enpl
metronidazole
dc.subject.enpl
TLC-densitometry
dc.subject.enpl
validation of the method
dc.subject.enpl
stability testing
dc.subject.enpl
silver(I) complex
dc.subtypepl
Article
dc.titlepl
Stability of Metronidazole and Its Complexes with Silver(I) Salts under Various Stress Conditions
dc.title.journalpl
Molecules
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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