Effects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness : results from a cross-sectional study in a nonclinical sample

2020
journal article
article
6
cris.lastimport.wos2024-04-09T19:40:06Z
dc.abstract.enBackground: there is a growing number of studies showing interactions between genetic polymorphisms associated with dopaminergic neurotransmission and traumatic life events (TLEs) on a risk of psychotic-like experiences (PLEs). Anomalous self-experiences (ASEs) have been associated both with TLEs as well as with PLEs. However, it remains unknown what is the role of ASEs in the complexity of gene - environment interactions on the emergence of PLEs. Patients and methods: we included 445 young adults - university students from three big cities in Poland. We used the Traumatic Events Checklist to assess TLEs, the Inventory of Psychotic-Like anomalous self-experiences in order to measure ASEs, and the Prodromal Questionnaire (PQ16) to record the level of PLEs. The following gene polymorphisms, related to dopaminergic neurotransmission, were determined: the catechol-O-methyltransferase (COMT) rs4680 polymorphism, the dopamine D2 receptor (DRD2) rs6277 polymorphism, and the dopamine transporter 1 (DAT1) rs28363170 polymorphism. Results: there was a significant effect of the interaction between the DAT1 polymorphism, a severity of ASEs, and a history of TLEs on the level of PLEs. Among the DAT1 10R/10R homozygotes with low level of ASEs, a severity of PLEs was significantly higher in individuals with a history of any TLEs. Higher scores of the PQ16 were associated with a greater severity of ASEs both in the DAT1 9R allele carriers and the DAT1 10R/10R homozygotes. Conclusion: our findings imply that genetic liability related to aberrant dopamine transport might impact the association between TLEs and PLEs in subjects with high levels of ASEs.pl
dc.affiliationWydział Filozoficzny : Instytut Psychologiipl
dc.affiliationWydział Lekarski : Zakład Psychiatrii Środowiskowejpl
dc.cm.id102263
dc.contributor.authorFrydecka, Dorotapl
dc.contributor.authorKotowicz, Kamilapl
dc.contributor.authorGawęda, Łukaszpl
dc.contributor.authorProchwicz, Katarzyna - 131546 pl
dc.contributor.authorKłosowska, Joanna - 138897 pl
dc.contributor.authorRymaszewska, Joannapl
dc.contributor.authorSamochowiec, Agnieszkapl
dc.contributor.authorSamochowiec, Jerzypl
dc.contributor.authorPodwalski, Piotrpl
dc.contributor.authorPawlak-Adamska, Edytapl
dc.contributor.authorSzmida, Elżbietapl
dc.contributor.authorCechnicki, Andrzej - 128966 pl
dc.contributor.authorMisiak, Błażejpl
dc.date.accessioned2021-01-08T09:38:01Z
dc.date.available2021-01-08T09:38:01Z
dc.date.issued2020pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number1pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume63pl
dc.identifier.articleide104pl
dc.identifier.doi10.1192/j.eurpsy.2020.103pl
dc.identifier.eissn1778-3585pl
dc.identifier.issn0924-9338pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/259955
dc.languageengpl
dc.language.containerengpl
dc.pbn.affiliationDziedzina nauk społecznych : psychologiapl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeinne
dc.subject.enanomalous self-experiencespl
dc.subject.enchildhood traumapl
dc.subject.enpsychosispl
dc.subject.enschizophreniapl
dc.subject.enstresspl
dc.subtypeArticlepl
dc.titleEffects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness : results from a cross-sectional study in a nonclinical samplepl
dc.title.journalEuropean Psychiatrypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T19:40:06Z
dc.abstract.enpl
Background: there is a growing number of studies showing interactions between genetic polymorphisms associated with dopaminergic neurotransmission and traumatic life events (TLEs) on a risk of psychotic-like experiences (PLEs). Anomalous self-experiences (ASEs) have been associated both with TLEs as well as with PLEs. However, it remains unknown what is the role of ASEs in the complexity of gene - environment interactions on the emergence of PLEs. Patients and methods: we included 445 young adults - university students from three big cities in Poland. We used the Traumatic Events Checklist to assess TLEs, the Inventory of Psychotic-Like anomalous self-experiences in order to measure ASEs, and the Prodromal Questionnaire (PQ16) to record the level of PLEs. The following gene polymorphisms, related to dopaminergic neurotransmission, were determined: the catechol-O-methyltransferase (COMT) rs4680 polymorphism, the dopamine D2 receptor (DRD2) rs6277 polymorphism, and the dopamine transporter 1 (DAT1) rs28363170 polymorphism. Results: there was a significant effect of the interaction between the DAT1 polymorphism, a severity of ASEs, and a history of TLEs on the level of PLEs. Among the DAT1 10R/10R homozygotes with low level of ASEs, a severity of PLEs was significantly higher in individuals with a history of any TLEs. Higher scores of the PQ16 were associated with a greater severity of ASEs both in the DAT1 9R allele carriers and the DAT1 10R/10R homozygotes. Conclusion: our findings imply that genetic liability related to aberrant dopamine transport might impact the association between TLEs and PLEs in subjects with high levels of ASEs.
dc.affiliationpl
Wydział Filozoficzny : Instytut Psychologii
dc.affiliationpl
Wydział Lekarski : Zakład Psychiatrii Środowiskowej
dc.cm.id
102263
dc.contributor.authorpl
Frydecka, Dorota
dc.contributor.authorpl
Kotowicz, Kamila
dc.contributor.authorpl
Gawęda, Łukasz
dc.contributor.authorpl
Prochwicz, Katarzyna - 131546
dc.contributor.authorpl
Kłosowska, Joanna - 138897
dc.contributor.authorpl
Rymaszewska, Joanna
dc.contributor.authorpl
Samochowiec, Agnieszka
dc.contributor.authorpl
Samochowiec, Jerzy
dc.contributor.authorpl
Podwalski, Piotr
dc.contributor.authorpl
Pawlak-Adamska, Edyta
dc.contributor.authorpl
Szmida, Elżbieta
dc.contributor.authorpl
Cechnicki, Andrzej - 128966
dc.contributor.authorpl
Misiak, Błażej
dc.date.accessioned
2021-01-08T09:38:01Z
dc.date.available
2021-01-08T09:38:01Z
dc.date.issuedpl
2020
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
1
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
63
dc.identifier.articleidpl
e104
dc.identifier.doipl
10.1192/j.eurpsy.2020.103
dc.identifier.eissnpl
1778-3585
dc.identifier.issnpl
0924-9338
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/259955
dc.languagepl
eng
dc.language.containerpl
eng
dc.pbn.affiliationpl
Dziedzina nauk społecznych : psychologia
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
inne
dc.subject.enpl
anomalous self-experiences
dc.subject.enpl
childhood trauma
dc.subject.enpl
psychosis
dc.subject.enpl
schizophrenia
dc.subject.enpl
stress
dc.subtypepl
Article
dc.titlepl
Effects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness : results from a cross-sectional study in a nonclinical sample
dc.title.journalpl
European Psychiatry
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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