Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia

2019
journal article
article
13
cris.lastimport.wos2024-04-09T19:41:47Z
dc.abstract.enBackground: In this study, we aimed to analyze differences in plasma protein abundances between infants with and without bronchopulmonary dysplasia (BPD), to add new insights into a better understanding of the pathogenesis of this disease. Methods: Cord and peripheral blood of neonates (≤ 30 weeks gestational age) was drawn at birth and at the 36th postmenstrual week (36 PMA), respectively. Blood samples were retrospectively subdivided into BPD(+) and BPD(−) groups, according to the development of BPD. Results: Children with BPD were characterized by decreased afamin, gelsolin and carboxypeptidase N subunit 2 levels in cord blood, and decreased galectin-3 binding protein and hemoglobin subunit gamma-1 levels, as well as an increased serotransferrin abundance in plasma at the 36 PMA. Conclusions: BPD development is associated with the plasma proteome changes in preterm infants, adding further evidence for the possible involvement of disturbances in vitamin E availability and impaired immunological processes in the progression of prematurity pulmonary complications. Moreover, it also points to the differences in proteins related to infection resistance and maintaining an adequate level of hematocrit in infants diagnosed with BPD.pl
dc.affiliationWydział Lekarski : Instytut Pediatriipl
dc.affiliationWydział Lekarski : Zakład Farmakologiipl
dc.affiliationWydział Lekarski : Zakład Farmakologii Klinicznejpl
dc.cm.date2020-12-02
dc.cm.id95652
dc.contributor.authorZasada, Magdalena - 200766 pl
dc.contributor.authorSuski, Maciej - 162260 pl
dc.contributor.authorBokiniec, Renatapl
dc.contributor.authorSzwarc-Duma, Monikapl
dc.contributor.authorBorszewska-Kornacka, Maria Katarzynapl
dc.contributor.authorMadej, Józef - 130786 pl
dc.contributor.authorBujak-Giżycka, Beata - 128922 pl
dc.contributor.authorMadetko-Talowska, Anna - 200563 pl
dc.contributor.authorRevhaug, Ceciliepl
dc.contributor.authorBaumbusch, Lars O.pl
dc.contributor.authorSaugstad, Ola Didrikpl
dc.contributor.authorPietrzyk, Jacek J. - 133150 pl
dc.contributor.authorKwinta, Przemko - 130598 pl
dc.date.accession2019-10-07pl
dc.date.accessioned2020-12-02T10:07:34Zpl
dc.date.available2020-12-02T10:07:34Zpl
dc.date.issued2019pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number1pl
dc.description.points70pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume45pl
dc.identifier.articleid112pl
dc.identifier.doi10.1186/s13052-019-0676-0pl
dc.identifier.eissn1824-7288pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/256001
dc.identifier.weblinkhttps://ijponline.biomedcentral.com/track/pdf/10.1186/s13052-019-0676-0pl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subtypeArticlepl
dc.titleComparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasiapl
dc.title.journalItalian Journal of Pediatricspl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T19:41:47Z
dc.abstract.enpl
Background: In this study, we aimed to analyze differences in plasma protein abundances between infants with and without bronchopulmonary dysplasia (BPD), to add new insights into a better understanding of the pathogenesis of this disease. Methods: Cord and peripheral blood of neonates (≤ 30 weeks gestational age) was drawn at birth and at the 36th postmenstrual week (36 PMA), respectively. Blood samples were retrospectively subdivided into BPD(+) and BPD(−) groups, according to the development of BPD. Results: Children with BPD were characterized by decreased afamin, gelsolin and carboxypeptidase N subunit 2 levels in cord blood, and decreased galectin-3 binding protein and hemoglobin subunit gamma-1 levels, as well as an increased serotransferrin abundance in plasma at the 36 PMA. Conclusions: BPD development is associated with the plasma proteome changes in preterm infants, adding further evidence for the possible involvement of disturbances in vitamin E availability and impaired immunological processes in the progression of prematurity pulmonary complications. Moreover, it also points to the differences in proteins related to infection resistance and maintaining an adequate level of hematocrit in infants diagnosed with BPD.
dc.affiliationpl
Wydział Lekarski : Instytut Pediatrii
dc.affiliationpl
Wydział Lekarski : Zakład Farmakologii
dc.affiliationpl
Wydział Lekarski : Zakład Farmakologii Klinicznej
dc.cm.date
2020-12-02
dc.cm.id
95652
dc.contributor.authorpl
Zasada, Magdalena - 200766
dc.contributor.authorpl
Suski, Maciej - 162260
dc.contributor.authorpl
Bokiniec, Renata
dc.contributor.authorpl
Szwarc-Duma, Monika
dc.contributor.authorpl
Borszewska-Kornacka, Maria Katarzyna
dc.contributor.authorpl
Madej, Józef - 130786
dc.contributor.authorpl
Bujak-Giżycka, Beata - 128922
dc.contributor.authorpl
Madetko-Talowska, Anna - 200563
dc.contributor.authorpl
Revhaug, Cecilie
dc.contributor.authorpl
Baumbusch, Lars O.
dc.contributor.authorpl
Saugstad, Ola Didrik
dc.contributor.authorpl
Pietrzyk, Jacek J. - 133150
dc.contributor.authorpl
Kwinta, Przemko - 130598
dc.date.accessionpl
2019-10-07
dc.date.accessionedpl
2020-12-02T10:07:34Z
dc.date.availablepl
2020-12-02T10:07:34Z
dc.date.issuedpl
2019
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
1
dc.description.pointspl
70
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
45
dc.identifier.articleidpl
112
dc.identifier.doipl
10.1186/s13052-019-0676-0
dc.identifier.eissnpl
1824-7288
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/256001
dc.identifier.weblinkpl
https://ijponline.biomedcentral.com/track/pdf/10.1186/s13052-019-0676-0
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subtypepl
Article
dc.titlepl
Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
dc.title.journalpl
Italian Journal of Pediatrics
dc.typepl
JournalArticle
dspace.entity.type
Publication

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