Increased expression of selected very late antigen integrin subunits on CD4 and CD8 blood T lymphocytes in patients with clinically stable asymptomatic atopic asthma

2012
journal article
article
cris.lastimport.wos2024-04-10T02:48:30Z
dc.abstract.enRecruitment of the inflammatory cells from blood to the airways in asthma is mediated by adhesive molecules, e.g. selectins and integrins. The most important integrins in cells trafficking are molecules containing $\alpha_{4}$ and $\beta_{2}$ subunits. We hypothesized that also $\alpha_{1}\beta_{1}$ and $\alpha_{2}\beta_{1}$ integrins (both found by us on blood eosinophils. To assess the expression of selected very late antigen (VLA) subunits ($\alpha_{1}$, $\alpha_{2}$, $\alpha_{4}$ and $\beta_{1}$) on blood CD4 and CD8 T lymphocytes from stable atopic asthmatic patients. of asthmatic subjects) are important in asthma pathogenesis. The study was conducted on 25 adult atopic asthmatics (mild to moderate persistent asthma in a stable clinical condition) and 17 matched healthy controls using flow cytometry. Expression of $\alpha_{4}$ and $\beta_{1}$ on CD4 T cells was significantly higher in asthma than in controls. The $\alpha_{1}$ subunit was absent from blood lymphocytes. The $\alpha_{2}$ chain hardly detected on lymphocytes from healthy subjects was distinctively present in asthmatics. Surprisingly, in subjects suffering from asthma for longer than 4 years (n = 15), the overexpression of $\alpha_{2}$, $\alpha_{4}$ and $\beta_{1}$ was observed on both: CD4 and CD8 T cells. Expression of selected VLA subunits on blood T cells may depend on asthma duration. The biological role of $\alpha_{2}\beta_{1}$ integrin in asthma is unknown, but as it was described as a stimulator of collagen accumulation in the airways, $\alpha_{2}\beta_{1}$ integrin could be, at least in part, responsible for asthma airway remodelling.pl
dc.affiliationWydział Lekarski : Klinika Alergii i Immunologiipl
dc.affiliationWydział Lekarski : II Katedra Chorób Wewnętrznych im. Profesora Andrzeja Szczeklikapl
dc.contributor.authorBazan-Socha, Stanisława - 159960 pl
dc.contributor.authorŻuk, Joanna - 141047 pl
dc.contributor.authorMusiał, Jacek - 131073 pl
dc.date.accession2020-06-03pl
dc.date.accessioned2020-06-04T14:07:49Z
dc.date.available2020-06-04T14:07:49Z
dc.date.issued2012pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 341-342pl
dc.description.number5pl
dc.description.physical337-342pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume29pl
dc.identifier.doi10.5114/pdia.2012.31485pl
dc.identifier.eissn2299-0046pl
dc.identifier.issn1642-395Xpl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/157001
dc.identifier.weblinkhttps://www.termedia.pl/Original-paper-Increased-expression-of-selected-very-late-antigen-integrin-subunits-on-CD4-and-CD8-blood-T-lymphocytes-in-patients-with-clinically-stable-asymptomatic-atopic-asthma,7,19653,0,1.htmlpl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-SA
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enasthmapl
dc.subject.enintegrinspl
dc.subject.encollagen receptorspl
dc.subject.enairway remodellingpl
dc.subject.eninflammationpl
dc.subtypeArticlepl
dc.titleIncreased expression of selected very late antigen integrin subunits on CD4 and CD8 blood T lymphocytes in patients with clinically stable asymptomatic atopic asthmapl
dc.title.journalPostępy Dermatologii i Alergologiipl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T02:48:30Z
dc.abstract.enpl
Recruitment of the inflammatory cells from blood to the airways in asthma is mediated by adhesive molecules, e.g. selectins and integrins. The most important integrins in cells trafficking are molecules containing $\alpha_{4}$ and $\beta_{2}$ subunits. We hypothesized that also $\alpha_{1}\beta_{1}$ and $\alpha_{2}\beta_{1}$ integrins (both found by us on blood eosinophils. To assess the expression of selected very late antigen (VLA) subunits ($\alpha_{1}$, $\alpha_{2}$, $\alpha_{4}$ and $\beta_{1}$) on blood CD4 and CD8 T lymphocytes from stable atopic asthmatic patients. of asthmatic subjects) are important in asthma pathogenesis. The study was conducted on 25 adult atopic asthmatics (mild to moderate persistent asthma in a stable clinical condition) and 17 matched healthy controls using flow cytometry. Expression of $\alpha_{4}$ and $\beta_{1}$ on CD4 T cells was significantly higher in asthma than in controls. The $\alpha_{1}$ subunit was absent from blood lymphocytes. The $\alpha_{2}$ chain hardly detected on lymphocytes from healthy subjects was distinctively present in asthmatics. Surprisingly, in subjects suffering from asthma for longer than 4 years (n = 15), the overexpression of $\alpha_{2}$, $\alpha_{4}$ and $\beta_{1}$ was observed on both: CD4 and CD8 T cells. Expression of selected VLA subunits on blood T cells may depend on asthma duration. The biological role of $\alpha_{2}\beta_{1}$ integrin in asthma is unknown, but as it was described as a stimulator of collagen accumulation in the airways, $\alpha_{2}\beta_{1}$ integrin could be, at least in part, responsible for asthma airway remodelling.
dc.affiliationpl
Wydział Lekarski : Klinika Alergii i Immunologii
dc.affiliationpl
Wydział Lekarski : II Katedra Chorób Wewnętrznych im. Profesora Andrzeja Szczeklika
dc.contributor.authorpl
Bazan-Socha, Stanisława - 159960
dc.contributor.authorpl
Żuk, Joanna - 141047
dc.contributor.authorpl
Musiał, Jacek - 131073
dc.date.accessionpl
2020-06-03
dc.date.accessioned
2020-06-04T14:07:49Z
dc.date.available
2020-06-04T14:07:49Z
dc.date.issuedpl
2012
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 341-342
dc.description.numberpl
5
dc.description.physicalpl
337-342
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
29
dc.identifier.doipl
10.5114/pdia.2012.31485
dc.identifier.eissnpl
2299-0046
dc.identifier.issnpl
1642-395X
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/157001
dc.identifier.weblinkpl
https://www.termedia.pl/Original-paper-Increased-expression-of-selected-very-late-antigen-integrin-subunits-on-CD4-and-CD8-blood-T-lymphocytes-in-patients-with-clinically-stable-asymptomatic-atopic-asthma,7,19653,0,1.html
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-SA
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
asthma
dc.subject.enpl
integrins
dc.subject.enpl
collagen receptors
dc.subject.enpl
airway remodelling
dc.subject.enpl
inflammation
dc.subtypepl
Article
dc.titlepl
Increased expression of selected very late antigen integrin subunits on CD4 and CD8 blood T lymphocytes in patients with clinically stable asymptomatic atopic asthma
dc.title.journalpl
Postępy Dermatologii i Alergologii
dc.typepl
JournalArticle
dspace.entity.type
Publication

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