Long-term effects of aircraft noise exposure on vascular oxidative stress, endothelial function and blood pressure : no evidence for adaptation or tolerance development

2022
journal article
article
13
cris.lastimport.wos2024-04-09T18:40:21Z
dc.abstract.enTransportation noise is recognized as an important cardiovascular risk factor. Key mechanisms are noise-triggered vascular inflammation and oxidative stress with subsequent endothelial dysfunction. Here, we test for adaptation or tolerance mechanisms in mice in response to chronic noise exposure. C57BL/6J mice were exposed to aircraft noise for 0, 4, 7, 14 and 28d at a mean sound pressure level of 72 dB(A) and peak levels of 85 dB(A). Chronic aircraft noise exposure up to 28d caused persistent endothelial dysfunction and elevation of blood pressure. Likewise, reactive oxygen species (ROS) formation as determined by dihydroethidium (DHE) staining and HPLC-based measurement of superoxide formation in the aorta/heart/brain was time-dependently increased by noise. Oxidative burst in the whole blood showed a maximum at 4d or 7d of noise exposure. Increased superoxide formation in the brain was mirrored by a downregulation of neuronal nitric oxide synthase (Nos3) and transcription factor Foxo3 genes, whereas Vcam1 mRNA, a marker for inflammation was upregulated in all noise exposure groups. Induction of a pronounced hearing loss in the mice was excluded by auditory brainstem response audiometry. Endothelial dysfunction and inflammation were present during the entire 28d of aircraft noise exposure. ROS formation gradually increases with ongoing exposure without significant adaptation or tolerance in mice in response to chronic noise stress at moderate levels. These data further illustrate health side effects of long-term noise exposure and further strengthen a consequent implementation of the WHO noise guidelines in order to prevent the development of noise-related future cardiovascular disease.pl
dc.affiliationPion Prorektora ds. badań naukowych : Jagiellońskie Centrum Rozwoju Lekówpl
dc.cm.id107528pl
dc.cm.idOmegaUJCM65c0153fec9b44f4811f48fabeb6bd2fpl
dc.contributor.authorFrenis, Katiepl
dc.contributor.authorKalinovic, Sanelapl
dc.contributor.authorErnst, Benjamin P.pl
dc.contributor.authorKvandova, Miroslavapl
dc.contributor.authorAl Zuabi, Ahmadpl
dc.contributor.authorKuntic, Marinpl
dc.contributor.authorOelze, Matthiaspl
dc.contributor.authorStamm, Paulpl
dc.contributor.authorBayo Jimenez, Maria Teresapl
dc.contributor.authorKij, Agnieszka - 215016 pl
dc.contributor.authorKeppeler, Karinpl
dc.contributor.authorKlein, Veroniquepl
dc.contributor.authorStrohm, Leapl
dc.contributor.authorUbbens, Henningpl
dc.contributor.authorDaub, Steffenpl
dc.contributor.authorHahad, Omarpl
dc.contributor.authorKröller-Schön, Swenjapl
dc.contributor.authorSchmeisser, Michael J.pl
dc.contributor.authorChłopicki, Stefan - 128995 pl
dc.contributor.authorEckrich, Jonaspl
dc.contributor.authorStrieth, Sebastianpl
dc.contributor.authorDaiber, Andreaspl
dc.contributor.authorSteven, Sebastianpl
dc.contributor.authorMünzel, Thomaspl
dc.date.accession2022-03-19pl
dc.date.accessioned2022-03-14T07:23:57Z
dc.date.available2022-03-14T07:23:57Z
dc.date.issued2022pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.versionostateczna wersja wydawcy
dc.description.volume8pl
dc.identifier.articleid814921pl
dc.identifier.doi10.3389/fmolb.2021.814921pl
dc.identifier.eissn2296-889Xpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/289033
dc.identifier.weblinkhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.814921/fullpl
dc.languageengpl
dc.language.containerengpl
dc.pbn.affiliationDziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeOtwarte czasopismo
dc.subtypeArticlepl
dc.titleLong-term effects of aircraft noise exposure on vascular oxidative stress, endothelial function and blood pressure : no evidence for adaptation or tolerance developmentpl
dc.title.journalFrontiers in Molecular Biosciencespl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T18:40:21Z
dc.abstract.enpl
Transportation noise is recognized as an important cardiovascular risk factor. Key mechanisms are noise-triggered vascular inflammation and oxidative stress with subsequent endothelial dysfunction. Here, we test for adaptation or tolerance mechanisms in mice in response to chronic noise exposure. C57BL/6J mice were exposed to aircraft noise for 0, 4, 7, 14 and 28d at a mean sound pressure level of 72 dB(A) and peak levels of 85 dB(A). Chronic aircraft noise exposure up to 28d caused persistent endothelial dysfunction and elevation of blood pressure. Likewise, reactive oxygen species (ROS) formation as determined by dihydroethidium (DHE) staining and HPLC-based measurement of superoxide formation in the aorta/heart/brain was time-dependently increased by noise. Oxidative burst in the whole blood showed a maximum at 4d or 7d of noise exposure. Increased superoxide formation in the brain was mirrored by a downregulation of neuronal nitric oxide synthase (Nos3) and transcription factor Foxo3 genes, whereas Vcam1 mRNA, a marker for inflammation was upregulated in all noise exposure groups. Induction of a pronounced hearing loss in the mice was excluded by auditory brainstem response audiometry. Endothelial dysfunction and inflammation were present during the entire 28d of aircraft noise exposure. ROS formation gradually increases with ongoing exposure without significant adaptation or tolerance in mice in response to chronic noise stress at moderate levels. These data further illustrate health side effects of long-term noise exposure and further strengthen a consequent implementation of the WHO noise guidelines in order to prevent the development of noise-related future cardiovascular disease.
dc.affiliationpl
Pion Prorektora ds. badań naukowych : Jagiellońskie Centrum Rozwoju Leków
dc.cm.idpl
107528
dc.cm.idOmegapl
UJCM65c0153fec9b44f4811f48fabeb6bd2f
dc.contributor.authorpl
Frenis, Katie
dc.contributor.authorpl
Kalinovic, Sanela
dc.contributor.authorpl
Ernst, Benjamin P.
dc.contributor.authorpl
Kvandova, Miroslava
dc.contributor.authorpl
Al Zuabi, Ahmad
dc.contributor.authorpl
Kuntic, Marin
dc.contributor.authorpl
Oelze, Matthias
dc.contributor.authorpl
Stamm, Paul
dc.contributor.authorpl
Bayo Jimenez, Maria Teresa
dc.contributor.authorpl
Kij, Agnieszka - 215016
dc.contributor.authorpl
Keppeler, Karin
dc.contributor.authorpl
Klein, Veronique
dc.contributor.authorpl
Strohm, Lea
dc.contributor.authorpl
Ubbens, Henning
dc.contributor.authorpl
Daub, Steffen
dc.contributor.authorpl
Hahad, Omar
dc.contributor.authorpl
Kröller-Schön, Swenja
dc.contributor.authorpl
Schmeisser, Michael J.
dc.contributor.authorpl
Chłopicki, Stefan - 128995
dc.contributor.authorpl
Eckrich, Jonas
dc.contributor.authorpl
Strieth, Sebastian
dc.contributor.authorpl
Daiber, Andreas
dc.contributor.authorpl
Steven, Sebastian
dc.contributor.authorpl
Münzel, Thomas
dc.date.accessionpl
2022-03-19
dc.date.accessioned
2022-03-14T07:23:57Z
dc.date.available
2022-03-14T07:23:57Z
dc.date.issuedpl
2022
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
8
dc.identifier.articleidpl
814921
dc.identifier.doipl
10.3389/fmolb.2021.814921
dc.identifier.eissnpl
2296-889X
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/289033
dc.identifier.weblinkpl
https://www.frontiersin.org/articles/10.3389/fmolb.2021.814921/full
dc.languagepl
eng
dc.language.containerpl
eng
dc.pbn.affiliation
Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
Otwarte czasopismo
dc.subtypepl
Article
dc.titlepl
Long-term effects of aircraft noise exposure on vascular oxidative stress, endothelial function and blood pressure : no evidence for adaptation or tolerance development
dc.title.journalpl
Frontiers in Molecular Biosciences
dc.typepl
JournalArticle
dspace.entity.type
Publication

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