Levels of tissue factor pathway inhibitor in patients with inflammatory bowel disease

2019
journal article
article
8
cris.lastimport.wos2024-04-10T02:44:34Z
dc.abstract.enEndothelial dysfunction has been reported to be involved in the pathogenesis of inflammatory bowel disease (IBD) and concomitant thromboembolic complications. Inflammation stimulates the expression of tissue factor and tissue factor pathway inhibitor (TFPI) by endothelial cells. This study assessed the relationship between TFPI levels and disease activity in patients with IBD. A total of 50 consecutive adult patients with ulcerative colitis (UC), 50 patients with Crohn disease (CD), and 50 healthy controls were enrolled to the study. Plasma levels of total TFPI, free TFPI, and von Willebrand factor were measured. Associations among these levels, disease activity, and inflammatory marker levels were assessed. Total TFPI levels were higher in patients with IBD (median, 68.5 [IQR, 60.2-80.1] ng/ml) than in controls (median, 61.1 ng/ml [IQR, 54.3-74.2]; P = 0.01). Free TFPI levels were higher in patients with active UC (median, 12.8 ng/ml [IQR, 11.1-15.4]), inactive UC (median, 9.9 ng/ml [IQR, 7.3-11.5]), active CD (median, 11.7 [IQR, 9.7-14.4] ng/ml), and inactive CD (median,], 9.7 ng/ml [IQR, 8.6-11.6]) than in controls (median, 5.5 ng/ml [IQR, 4.3-7.2]; P <0.001). In the CD and UC groups, free TFPI levels correlated with the levels of inflammatory markers and disease activity. The von Willebrand factor level was higher in patients with UC (median, 143.4 IU/dl [IQR, 115.5–170.4]) and those with CD (median, 151.8 IU/dl [IQR, 112.8-189.4]) than in controls (85.1 IU/dl [IQR, 77.1-101.5]; P <0.001 for both comparisons). The anticoagulant TFPI pathway is activated during remissions and flares in patients with IBD. The free TFPI level correlates with biochemical markers of inflammation and disease activity.pl
dc.affiliationWydział Lekarski : Instytut Stomatologiipl
dc.affiliationWydział Lekarski : Klinika Gastroenterologii i Hepatologiipl
dc.cm.date2020-01-07
dc.cm.id94131
dc.contributor.authorCibor, Dorota - 129029 pl
dc.contributor.authorSzczeklik, Katarzyna - 133560 pl
dc.contributor.authorMach, Tomasz - 130768 pl
dc.contributor.authorOwczarek, Danuta - 133057 pl
dc.date.accessioned2020-01-17T10:09:05Z
dc.date.available2020-01-17T10:09:05Z
dc.date.issued2019pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number4pl
dc.description.physical253-258pl
dc.description.points100pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume129pl
dc.identifier.doi10.20452/pamw.4481pl
dc.identifier.eissn1897-9483pl
dc.identifier.issn0032-3772pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/146079
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-SA
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enCrohn diseasepl
dc.subject.enendothelial dysfunctionpl
dc.subject.entissue factor inhibitorpl
dc.subject.enulcerative colitispl
dc.subject.envon Willebrand factorpl
dc.subtypeArticlepl
dc.titleLevels of tissue factor pathway inhibitor in patients with inflammatory bowel diseasepl
dc.title.journalPolskie Archiwum Medycyny Wewnętrznej = Polish Archives of Internal Medicinepl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T02:44:34Z
dc.abstract.enpl
Endothelial dysfunction has been reported to be involved in the pathogenesis of inflammatory bowel disease (IBD) and concomitant thromboembolic complications. Inflammation stimulates the expression of tissue factor and tissue factor pathway inhibitor (TFPI) by endothelial cells. This study assessed the relationship between TFPI levels and disease activity in patients with IBD. A total of 50 consecutive adult patients with ulcerative colitis (UC), 50 patients with Crohn disease (CD), and 50 healthy controls were enrolled to the study. Plasma levels of total TFPI, free TFPI, and von Willebrand factor were measured. Associations among these levels, disease activity, and inflammatory marker levels were assessed. Total TFPI levels were higher in patients with IBD (median, 68.5 [IQR, 60.2-80.1] ng/ml) than in controls (median, 61.1 ng/ml [IQR, 54.3-74.2]; P = 0.01). Free TFPI levels were higher in patients with active UC (median, 12.8 ng/ml [IQR, 11.1-15.4]), inactive UC (median, 9.9 ng/ml [IQR, 7.3-11.5]), active CD (median, 11.7 [IQR, 9.7-14.4] ng/ml), and inactive CD (median,], 9.7 ng/ml [IQR, 8.6-11.6]) than in controls (median, 5.5 ng/ml [IQR, 4.3-7.2]; P <0.001). In the CD and UC groups, free TFPI levels correlated with the levels of inflammatory markers and disease activity. The von Willebrand factor level was higher in patients with UC (median, 143.4 IU/dl [IQR, 115.5–170.4]) and those with CD (median, 151.8 IU/dl [IQR, 112.8-189.4]) than in controls (85.1 IU/dl [IQR, 77.1-101.5]; P <0.001 for both comparisons). The anticoagulant TFPI pathway is activated during remissions and flares in patients with IBD. The free TFPI level correlates with biochemical markers of inflammation and disease activity.
dc.affiliationpl
Wydział Lekarski : Instytut Stomatologii
dc.affiliationpl
Wydział Lekarski : Klinika Gastroenterologii i Hepatologii
dc.cm.date
2020-01-07
dc.cm.id
94131
dc.contributor.authorpl
Cibor, Dorota - 129029
dc.contributor.authorpl
Szczeklik, Katarzyna - 133560
dc.contributor.authorpl
Mach, Tomasz - 130768
dc.contributor.authorpl
Owczarek, Danuta - 133057
dc.date.accessioned
2020-01-17T10:09:05Z
dc.date.available
2020-01-17T10:09:05Z
dc.date.issuedpl
2019
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
4
dc.description.physicalpl
253-258
dc.description.pointspl
100
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
129
dc.identifier.doipl
10.20452/pamw.4481
dc.identifier.eissnpl
1897-9483
dc.identifier.issnpl
0032-3772
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/146079
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-SA
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
Crohn disease
dc.subject.enpl
endothelial dysfunction
dc.subject.enpl
tissue factor inhibitor
dc.subject.enpl
ulcerative colitis
dc.subject.enpl
von Willebrand factor
dc.subtypepl
Article
dc.titlepl
Levels of tissue factor pathway inhibitor in patients with inflammatory bowel disease
dc.title.journalpl
Polskie Archiwum Medycyny Wewnętrznej = Polish Archives of Internal Medicine
dc.typepl
JournalArticle
dspace.entity.type
Publication

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