Nanomaterial exposure, extracellular vesicle biogenesis and adverse cellular outcomes : a scoping review

2022
journal article
review article
9
dc.abstract.enThe progressively increasing use of nanomaterials (NMs) has awakened issues related to nanosafety and its potential toxic effects on human health. Emerging studies suggest that NMs alter cell communication by reshaping and altering the secretion of extracellular vesicles (EVs), leading to dysfunction in recipient cells. However, there is limited understanding of how the physicochemical characteristics of NMs alter the EV content and their consequent physiological functions. Therefore, this review explored the relevance of EVs in the nanotoxicology field. The current state of the art on how EVs are modulated by NM exposure and the possible regulation and modulation of signaling pathways and physiological responses were assessed in detail. This review followed the manual for reviewers produced by The Joanna Brigs Institute for Scoping Reviews and the PRISMA extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. The research question, "Do NMs modulate cellular responses mediated by EVs?" was analyzed following the PECO model (P (Population) = EVs, E (Exposure) = NMs, C (Comparator) = EVs without exposure to NMs, O (Outcome) = Cellular responses/change in EVs) to help methodologically assess the association between exposure and outcome. For each theme in the PECO acronym, keywords were defined, organized, and researched in PubMed, Science Direct, Scopus, Web of Science, EMBASE, and Cochrane databases, up to 30 September 2021. In vitro, in vivo, ex vivo, and clinical studies that analyzed the effect of NMs on EV biogenesis, cargo, and cellular responses were included in the analysis. The methodological quality assessment was conducted using the ToxRTool, ARRIVE guideline, Newcastle Ottawa and the EV-TRACK platform. The search in the referred databases identified 2944 articles. After applying the eligibility criteria and two-step screening, 18 articles were included in the final review. We observed that depending on the concentration and physicochemical characteristics, specific NMs promote a significant increase in EV secretion as well as changes in their cargo, especially regarding the expression of proteins and miRNAs, which, in turn, were involved in biological processes that included cell communication, angiogenesis, and activation of the immune response, etc. Although further studies are necessary, this work suggests that molecular investigations on EVs induced by NM exposure may become a potential tool for toxicological studies since they are widely accessible biomarkers that may form a bridge between NM exposure and the cellular response and pathological outcome.pl
dc.affiliationWydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiegopl
dc.contributor.authorLima, Thais S. M.pl
dc.contributor.authorSouza, Wandersonpl
dc.contributor.authorGeaquinto, Luths R. O.pl
dc.contributor.authorSanches, Priscila L.pl
dc.contributor.authorStępień, Ewa - 161583 pl
dc.contributor.authorMeneses, Joãopl
dc.contributor.authorFernández-de Gortari, Elipl
dc.contributor.authorMeisner-Kober, Nicolepl
dc.contributor.authorHimly, Martinpl
dc.contributor.authorGranjeiro, José M.pl
dc.contributor.authorRibeiro, Ana R.pl
dc.date.accessioned2022-12-05T11:35:18Z
dc.date.available2022-12-05T11:35:18Z
dc.date.issued2022pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalArtykuł należy do Wydania Specjalnego: "Health, Environment and Nanosafety"pl
dc.description.number7pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume12pl
dc.identifier.articleid1231pl
dc.identifier.doi10.3390/nano12071231pl
dc.identifier.eissn2079-4991pl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/304385
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.ennanomaterialspl
dc.subject.ennanotoxicologypl
dc.subject.enextracellular vesiclespl
dc.subject.encell communicationpl
dc.subtypeReviewArticlepl
dc.titleNanomaterial exposure, extracellular vesicle biogenesis and adverse cellular outcomes : a scoping reviewpl
dc.title.journalNanomaterials (Basel)pl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
The progressively increasing use of nanomaterials (NMs) has awakened issues related to nanosafety and its potential toxic effects on human health. Emerging studies suggest that NMs alter cell communication by reshaping and altering the secretion of extracellular vesicles (EVs), leading to dysfunction in recipient cells. However, there is limited understanding of how the physicochemical characteristics of NMs alter the EV content and their consequent physiological functions. Therefore, this review explored the relevance of EVs in the nanotoxicology field. The current state of the art on how EVs are modulated by NM exposure and the possible regulation and modulation of signaling pathways and physiological responses were assessed in detail. This review followed the manual for reviewers produced by The Joanna Brigs Institute for Scoping Reviews and the PRISMA extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. The research question, "Do NMs modulate cellular responses mediated by EVs?" was analyzed following the PECO model (P (Population) = EVs, E (Exposure) = NMs, C (Comparator) = EVs without exposure to NMs, O (Outcome) = Cellular responses/change in EVs) to help methodologically assess the association between exposure and outcome. For each theme in the PECO acronym, keywords were defined, organized, and researched in PubMed, Science Direct, Scopus, Web of Science, EMBASE, and Cochrane databases, up to 30 September 2021. In vitro, in vivo, ex vivo, and clinical studies that analyzed the effect of NMs on EV biogenesis, cargo, and cellular responses were included in the analysis. The methodological quality assessment was conducted using the ToxRTool, ARRIVE guideline, Newcastle Ottawa and the EV-TRACK platform. The search in the referred databases identified 2944 articles. After applying the eligibility criteria and two-step screening, 18 articles were included in the final review. We observed that depending on the concentration and physicochemical characteristics, specific NMs promote a significant increase in EV secretion as well as changes in their cargo, especially regarding the expression of proteins and miRNAs, which, in turn, were involved in biological processes that included cell communication, angiogenesis, and activation of the immune response, etc. Although further studies are necessary, this work suggests that molecular investigations on EVs induced by NM exposure may become a potential tool for toxicological studies since they are widely accessible biomarkers that may form a bridge between NM exposure and the cellular response and pathological outcome.
dc.affiliationpl
Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego
dc.contributor.authorpl
Lima, Thais S. M.
dc.contributor.authorpl
Souza, Wanderson
dc.contributor.authorpl
Geaquinto, Luths R. O.
dc.contributor.authorpl
Sanches, Priscila L.
dc.contributor.authorpl
Stępień, Ewa - 161583
dc.contributor.authorpl
Meneses, João
dc.contributor.authorpl
Fernández-de Gortari, Eli
dc.contributor.authorpl
Meisner-Kober, Nicole
dc.contributor.authorpl
Himly, Martin
dc.contributor.authorpl
Granjeiro, José M.
dc.contributor.authorpl
Ribeiro, Ana R.
dc.date.accessioned
2022-12-05T11:35:18Z
dc.date.available
2022-12-05T11:35:18Z
dc.date.issuedpl
2022
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Artykuł należy do Wydania Specjalnego: "Health, Environment and Nanosafety"
dc.description.numberpl
7
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
12
dc.identifier.articleidpl
1231
dc.identifier.doipl
10.3390/nano12071231
dc.identifier.eissnpl
2079-4991
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/304385
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
nanomaterials
dc.subject.enpl
nanotoxicology
dc.subject.enpl
extracellular vesicles
dc.subject.enpl
cell communication
dc.subtypepl
ReviewArticle
dc.titlepl
Nanomaterial exposure, extracellular vesicle biogenesis and adverse cellular outcomes : a scoping review
dc.title.journalpl
Nanomaterials (Basel)
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.

Views
6
Views per month
Views per city
Ashburn
2
Downloads
stepien_et-al_nanomaterial_exposure_extracellular_vesicle_biogenesis_and_adverse_cellular_2022.pdf
1