Polyphenol profile and pharmaceutical potential of Quercus spp. bark extracts

2019
journal article
article
55
dc.abstract.enTargeted profiling of polyphenols in trees may reveal valuable sources of natural compounds with major applications in pharmacology and disease control. The current study targeted the profiling of polyphenols using HPLC-DAD in Quercus robur, Q. macrocarpa and Q. acutissima bark extracts. Free radical scavenging of each extract was investigated using antioxidant assays. Antimicrobial activities against a wide spectrum of bacteria and fungi were explored, as well as anticancer activities against di erent cancer cell lines. The HPLC-DAD analyses revealed the availability of several polyphenols in high amounts, including ellagic acid (in Q. robur) and caffeic acid (in Q. macrocarpa) in all three species. The bioactivity assay revealed high antioxidant activity in Q. robur compared to that of the other species, as well as phenolic standards. The three oak bark extracts showed clear antibacterial activities against most bacteria tested, with the highest antibacterial activities in the extracts of Q. robur. In addition, the three extracts showed higher antibacterial activities against Pseudomonas aeruginosa, Micrococcus flavus, and Escherichia coli compared to that of other bacteria. There were strong antifungal activities against some fungi, such as Aspergillus flavus, Penicillium funiculosum, and Penicillium ochrochloron. There were also noticeable anticancer activities against MCF-7, HeLa, Jurkat, and HT-29 cell lines, with the highest anticancer activity in the extracts of Q. robur. This is the first study that reveals not only novel sources of important polyphenols (e.g., ellagic acid) in Q. robur, Q. macrocarpa and Q. acutissima bark but also their anticancer activities against diverse cancer cell lines.pl
dc.affiliationWydział Farmaceutyczny : Zakład Botaniki Farmaceutycznejpl
dc.cm.date2020-12-02
dc.cm.id96798
dc.contributor.authorElansary, Hosam O.pl
dc.contributor.authorSzopa, Agnieszka - 140550 pl
dc.contributor.authorKubica, Paweł - 169966 pl
dc.contributor.authorEkiert, Halina - 129339 pl
dc.contributor.authorMattar, Mohamed A.pl
dc.contributor.authorAl-Yafrasi, Mohamed A.pl
dc.contributor.authorEl-Ansary, Diaa O.pl
dc.contributor.authorZin El-Abedin, Tarek K.pl
dc.contributor.authorYessoufou, Kowiyoupl
dc.date.accession2020-03-09pl
dc.date.accessioned2020-12-02T10:22:37Zpl
dc.date.available2020-12-02T10:22:37Zpl
dc.date.issued2019pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number11pl
dc.description.points70pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume8pl
dc.identifier.articleid486pl
dc.identifier.doi10.3390/plants8110486pl
dc.identifier.eissn2223-7747pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/256434
dc.identifier.weblinkhttps://www.mdpi.com/2223-7747/8/11/486pl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enQuercus spp. bark extractpl
dc.subject.enflavan-3-olspl
dc.subject.enphenolic acidspl
dc.subject.enantimicrobialpl
dc.subject.enantioxidantpl
dc.subject.encytotoxicitypl
dc.subtypeArticlepl
dc.titlePolyphenol profile and pharmaceutical potential of Quercus spp. bark extractspl
dc.title.journalPlantspl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Targeted profiling of polyphenols in trees may reveal valuable sources of natural compounds with major applications in pharmacology and disease control. The current study targeted the profiling of polyphenols using HPLC-DAD in Quercus robur, Q. macrocarpa and Q. acutissima bark extracts. Free radical scavenging of each extract was investigated using antioxidant assays. Antimicrobial activities against a wide spectrum of bacteria and fungi were explored, as well as anticancer activities against di erent cancer cell lines. The HPLC-DAD analyses revealed the availability of several polyphenols in high amounts, including ellagic acid (in Q. robur) and caffeic acid (in Q. macrocarpa) in all three species. The bioactivity assay revealed high antioxidant activity in Q. robur compared to that of the other species, as well as phenolic standards. The three oak bark extracts showed clear antibacterial activities against most bacteria tested, with the highest antibacterial activities in the extracts of Q. robur. In addition, the three extracts showed higher antibacterial activities against Pseudomonas aeruginosa, Micrococcus flavus, and Escherichia coli compared to that of other bacteria. There were strong antifungal activities against some fungi, such as Aspergillus flavus, Penicillium funiculosum, and Penicillium ochrochloron. There were also noticeable anticancer activities against MCF-7, HeLa, Jurkat, and HT-29 cell lines, with the highest anticancer activity in the extracts of Q. robur. This is the first study that reveals not only novel sources of important polyphenols (e.g., ellagic acid) in Q. robur, Q. macrocarpa and Q. acutissima bark but also their anticancer activities against diverse cancer cell lines.
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Botaniki Farmaceutycznej
dc.cm.date
2020-12-02
dc.cm.id
96798
dc.contributor.authorpl
Elansary, Hosam O.
dc.contributor.authorpl
Szopa, Agnieszka - 140550
dc.contributor.authorpl
Kubica, Paweł - 169966
dc.contributor.authorpl
Ekiert, Halina - 129339
dc.contributor.authorpl
Mattar, Mohamed A.
dc.contributor.authorpl
Al-Yafrasi, Mohamed A.
dc.contributor.authorpl
El-Ansary, Diaa O.
dc.contributor.authorpl
Zin El-Abedin, Tarek K.
dc.contributor.authorpl
Yessoufou, Kowiyou
dc.date.accessionpl
2020-03-09
dc.date.accessionedpl
2020-12-02T10:22:37Z
dc.date.availablepl
2020-12-02T10:22:37Z
dc.date.issuedpl
2019
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
11
dc.description.pointspl
70
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
8
dc.identifier.articleidpl
486
dc.identifier.doipl
10.3390/plants8110486
dc.identifier.eissnpl
2223-7747
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/256434
dc.identifier.weblinkpl
https://www.mdpi.com/2223-7747/8/11/486
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
Quercus spp. bark extract
dc.subject.enpl
flavan-3-ols
dc.subject.enpl
phenolic acids
dc.subject.enpl
antimicrobial
dc.subject.enpl
antioxidant
dc.subject.enpl
cytotoxicity
dc.subtypepl
Article
dc.titlepl
Polyphenol profile and pharmaceutical potential of Quercus spp. bark extracts
dc.title.journalpl
Plants
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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