Infra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised rats

2013
journal article
article
26
dc.abstract.enMultiplicity of oscillatory phenomena in a range of infra-slow frequencies (<0.01 Hz) has been described in mammalian brains at different levels of organisation. The significance and manifestation in physiology and/or behaviour of many brain infra-slow oscillations (ISO) remain unknown. Examples of this phenomenon are two types of ISO observed in the brains of urethane-anaesthetised rats: infra-slow, rhythmic changes in the rate of action potential firing in a few nuclei of the subcortical visual system and a sleep-like cycle of activation/deactivation visible in the EEG signal. Because both of these rhythmic phenomena involve brain networks that can influence autonomic nervous system activity, we hypothesised that these two brain ISOs can be reflected by rhythmic changes of pupil size. Thus, in the present study, we used simultaneous pupillography and ECoG recording to verify the hypothesised existence of infra-slow oscillations in the pupil size of urethane-anaesthetised rats. The obtained results showed rhythmic changes in the size of the pupils and rhythmic eyeball movements in urethane-anaesthetised rats. The observed rhythms were characterised by two different dominant components in a range of infra-slow frequencies. First, the long component had a period of ≈29 minutes and was present in both the irises and the eyeball movements. Second, the short component had a period of ≈2 minutes and was observed only in the rhythmic constrictions and dilations of the pupils. Both ISOs were simultaneously present in both eyes, and they were synchronised between the left and right eye. The long ISO component was synchronised with the cyclic alternations of the brain state, as revealed by rhythmic changes in the pattern of the ECoG signal. Based on the obtained results, we propose a model of interference of ISO present in different brain systems involved in the control of pupil size.pl
dc.affiliationWydział Biologii i Nauk o Ziemi : Instytut Zoologiipl
dc.contributor.authorBłasiak, Tomasz - 127358 pl
dc.contributor.authorZawadzki, Arturpl
dc.contributor.authorLewandowski, Marian - 129942 pl
dc.date.accessioned2015-04-27T11:21:17Z
dc.date.available2015-04-27T11:21:17Z
dc.date.issued2013pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number4pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume8pl
dc.identifier.articleide62430pl
dc.identifier.doi10.1371/journal.pone.0062430pl
dc.identifier.eissn1932-6203pl
dc.identifier.projectROD UJ / Ppl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/5843
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses*
dc.share.typeotwarte czasopismo
dc.subject.enlateral geniculate nucleuspl
dc.subject.enolivary pretectal nucleuspl
dc.subject.enintergeniculate leafletpl
dc.subject.ensuprachiasmatic nucleuspl
dc.subject.enlight reflexpl
dc.subtypeArticlepl
dc.titleInfra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised ratspl
dc.title.journalPLoS ONEpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Multiplicity of oscillatory phenomena in a range of infra-slow frequencies (<0.01 Hz) has been described in mammalian brains at different levels of organisation. The significance and manifestation in physiology and/or behaviour of many brain infra-slow oscillations (ISO) remain unknown. Examples of this phenomenon are two types of ISO observed in the brains of urethane-anaesthetised rats: infra-slow, rhythmic changes in the rate of action potential firing in a few nuclei of the subcortical visual system and a sleep-like cycle of activation/deactivation visible in the EEG signal. Because both of these rhythmic phenomena involve brain networks that can influence autonomic nervous system activity, we hypothesised that these two brain ISOs can be reflected by rhythmic changes of pupil size. Thus, in the present study, we used simultaneous pupillography and ECoG recording to verify the hypothesised existence of infra-slow oscillations in the pupil size of urethane-anaesthetised rats. The obtained results showed rhythmic changes in the size of the pupils and rhythmic eyeball movements in urethane-anaesthetised rats. The observed rhythms were characterised by two different dominant components in a range of infra-slow frequencies. First, the long component had a period of ≈29 minutes and was present in both the irises and the eyeball movements. Second, the short component had a period of ≈2 minutes and was observed only in the rhythmic constrictions and dilations of the pupils. Both ISOs were simultaneously present in both eyes, and they were synchronised between the left and right eye. The long ISO component was synchronised with the cyclic alternations of the brain state, as revealed by rhythmic changes in the pattern of the ECoG signal. Based on the obtained results, we propose a model of interference of ISO present in different brain systems involved in the control of pupil size.
dc.affiliationpl
Wydział Biologii i Nauk o Ziemi : Instytut Zoologii
dc.contributor.authorpl
Błasiak, Tomasz - 127358
dc.contributor.authorpl
Zawadzki, Artur
dc.contributor.authorpl
Lewandowski, Marian - 129942
dc.date.accessioned
2015-04-27T11:21:17Z
dc.date.available
2015-04-27T11:21:17Z
dc.date.issuedpl
2013
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
4
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
8
dc.identifier.articleidpl
e62430
dc.identifier.doipl
10.1371/journal.pone.0062430
dc.identifier.eissnpl
1932-6203
dc.identifier.projectpl
ROD UJ / P
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/5843
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses
dc.share.type
otwarte czasopismo
dc.subject.enpl
lateral geniculate nucleus
dc.subject.enpl
olivary pretectal nucleus
dc.subject.enpl
intergeniculate leaflet
dc.subject.enpl
suprachiasmatic nucleus
dc.subject.enpl
light reflex
dc.subtypepl
Article
dc.titlepl
Infra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised rats
dc.title.journalpl
PLoS ONE
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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