Androgen signaling disruption during fetal and postnatal development affects androgen receptor and connexin 43 expression and distribution in adult boar prostate

2013
journal article
article
9
cris.lastimport.wos2024-04-10T02:50:08Z
dc.abstract.enTo date, limited knowledge exists regarding the role of the androgen signaling during specific periods of development in the regulation of androgen receptor (AR) and connexin 43 (Cx43) in adult prostate. Therefore, in this study we examined mRNA and protein expression, and tissue distribution of AR and Cx43 in adult boar prostates following fetal (GD20), neonatal (PD2), and prepubertal (PD90) exposure to an antiandrogen flutamide (50 mg/kg bw). In GD20 and PD2 males we found the reduction of the luminal compartment, inflammatory changes, decreased AR and increased Cx43 expression, and altered localization of both proteins. Moreover, enhanced apoptosis and reduced proliferation were detected in the prostates of these animals. In PD90 males the alterations were less evident, except that Cx43 expression was markedly upregulated. The results presented herein indicate that in boar androgen action during early fetal and neonatal periods plays a key role in the maintenance of normal phenotype and functions of prostatic cells at adulthood. Furthermore, we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.pl
dc.affiliationWydział Biologii i Nauk o Ziemi : Instytut Zoologiipl
dc.contributor.authorHejmej, Anna - 141886 pl
dc.contributor.authorGórowska-Wójtowicz, Ewelina - 150833 pl
dc.contributor.authorKotula-Balak, Małgorzata - 129241 pl
dc.contributor.authorChojnacka, Katarzyna - 118682 pl
dc.contributor.authorZarzycka, Marta - 104151 pl
dc.contributor.authorZając, Justynapl
dc.contributor.authorBilińska, Barbara - 127338 pl
dc.date.accessioned2015-07-01T17:52:41Z
dc.date.available2015-07-01T17:52:41Z
dc.date.issued2013pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalEwelina Górowska-Wójtowicz podpisana: Ewelina Górowskapl
dc.description.versionostateczna wersja wydawcy
dc.description.volume2013pl
dc.identifier.articleid407678pl
dc.identifier.doi10.1155/2013/407678pl
dc.identifier.eissn2314-6141pl
dc.identifier.issn2314-6133pl
dc.identifier.projectROD UJ / Ppl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/11076
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses*
dc.share.typeotwarte czasopismo
dc.subject.enboarpl
dc.subject.enprostatepl
dc.subject.enconnexin 43pl
dc.subject.enandrogen receptorpl
dc.subtypeArticlepl
dc.titleAndrogen signaling disruption during fetal and postnatal development affects androgen receptor and connexin 43 expression and distribution in adult boar prostatepl
dc.title.journalBioMed Research Internationalpl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T02:50:08Z
dc.abstract.enpl
To date, limited knowledge exists regarding the role of the androgen signaling during specific periods of development in the regulation of androgen receptor (AR) and connexin 43 (Cx43) in adult prostate. Therefore, in this study we examined mRNA and protein expression, and tissue distribution of AR and Cx43 in adult boar prostates following fetal (GD20), neonatal (PD2), and prepubertal (PD90) exposure to an antiandrogen flutamide (50 mg/kg bw). In GD20 and PD2 males we found the reduction of the luminal compartment, inflammatory changes, decreased AR and increased Cx43 expression, and altered localization of both proteins. Moreover, enhanced apoptosis and reduced proliferation were detected in the prostates of these animals. In PD90 males the alterations were less evident, except that Cx43 expression was markedly upregulated. The results presented herein indicate that in boar androgen action during early fetal and neonatal periods plays a key role in the maintenance of normal phenotype and functions of prostatic cells at adulthood. Furthermore, we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.
dc.affiliationpl
Wydział Biologii i Nauk o Ziemi : Instytut Zoologii
dc.contributor.authorpl
Hejmej, Anna - 141886
dc.contributor.authorpl
Górowska-Wójtowicz, Ewelina - 150833
dc.contributor.authorpl
Kotula-Balak, Małgorzata - 129241
dc.contributor.authorpl
Chojnacka, Katarzyna - 118682
dc.contributor.authorpl
Zarzycka, Marta - 104151
dc.contributor.authorpl
Zając, Justyna
dc.contributor.authorpl
Bilińska, Barbara - 127338
dc.date.accessioned
2015-07-01T17:52:41Z
dc.date.available
2015-07-01T17:52:41Z
dc.date.issuedpl
2013
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Ewelina Górowska-Wójtowicz podpisana: Ewelina Górowska
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
2013
dc.identifier.articleidpl
407678
dc.identifier.doipl
10.1155/2013/407678
dc.identifier.eissnpl
2314-6141
dc.identifier.issnpl
2314-6133
dc.identifier.projectpl
ROD UJ / P
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/11076
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses
dc.share.type
otwarte czasopismo
dc.subject.enpl
boar
dc.subject.enpl
prostate
dc.subject.enpl
connexin 43
dc.subject.enpl
androgen receptor
dc.subtypepl
Article
dc.titlepl
Androgen signaling disruption during fetal and postnatal development affects androgen receptor and connexin 43 expression and distribution in adult boar prostate
dc.title.journalpl
BioMed Research International
dc.typepl
JournalArticle
dspace.entity.type
Publication

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