Curcumin-poly(sodium 4-styrenesulfonate) conjugates as potent Zika virus entry inhibitors

2024
journal article
article
1
cris.lastimport.wos2024-04-09T18:35:16Z
dc.abstract.enCurcumin, a natural product with recognized antiviral properties, is limited in its application largely due to its poor solubility. This study presents the synthesis of water-soluble curcumin-poly(sodium 4-styrenesulfonate) (Cur-PSSNan) covalent conjugates. The antiflaviviral activity of conjugates was validated in vitro by using the Zika virus as a model. In the development of these water-soluble curcumin-containing derivatives, we used the macromolecules reported by us to also hamper viral infections. Mechanistic investigations indicated that the conjugates exhibited excellent stability and bioavailability. The curcumin and macromolecules in concerted action interact directly with virus particles and block their attachment to host cells, hampering the infection process.pl
dc.affiliationWydział Chemii : Zakład Chemii Fizycznej i Elektrochemiipl
dc.affiliationPion Prorektora ds. badań naukowych : Małopolskie Centrum Biotechnologiipl
dc.affiliationWydział Biochemii, Biofizyki i Biotechnologii : Zakład Biochemii Fizycznejpl
dc.affiliationSzkoła Doktorska Nauk Ścisłych i Przyrodniczychpl
dc.contributor.authorObłoza, Magdalena - 180217 pl
dc.contributor.authorMilewska, Aleksandra - 115344 pl
dc.contributor.authorBotwina, Paweł - 205270 pl
dc.contributor.authorSzczepański, Artur - 165863 pl
dc.contributor.authorMedaj, Aneta - 440745 pl
dc.contributor.authorBonarek, Piotr - 127398 pl
dc.contributor.authorSzczubiałka, Krzysztof - 132218 pl
dc.contributor.authorPyrć, Krzysztof - 161470 pl
dc.contributor.authorNowakowska, Maria - 131048 pl
dc.date.accessioned2024-02-16T14:01:06Z
dc.date.available2024-02-16T14:01:06Z
dc.date.issued2024pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 5435-5437pl
dc.description.number5pl
dc.description.physical5426-5437pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume16pl
dc.identifier.doi10.1021/acsami.3c13893pl
dc.identifier.eissn1944-8252pl
dc.identifier.issn1944-8244pl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/327224
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeinne
dc.subject.enZika viruspl
dc.subject.enantiviralpl
dc.subject.enpolymerpl
dc.subject.enpoly(sodium4-styrenesulfonate)pl
dc.subject.encurcuminpl
dc.subject.enflaviviruspl
dc.subtypeArticlepl
dc.titleCurcumin-poly(sodium 4-styrenesulfonate) conjugates as potent Zika virus entry inhibitorspl
dc.title.journalACS Applied Materials & Interfacespl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T18:35:16Z
dc.abstract.enpl
Curcumin, a natural product with recognized antiviral properties, is limited in its application largely due to its poor solubility. This study presents the synthesis of water-soluble curcumin-poly(sodium 4-styrenesulfonate) (Cur-PSSNan) covalent conjugates. The antiflaviviral activity of conjugates was validated in vitro by using the Zika virus as a model. In the development of these water-soluble curcumin-containing derivatives, we used the macromolecules reported by us to also hamper viral infections. Mechanistic investigations indicated that the conjugates exhibited excellent stability and bioavailability. The curcumin and macromolecules in concerted action interact directly with virus particles and block their attachment to host cells, hampering the infection process.
dc.affiliationpl
Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii
dc.affiliationpl
Pion Prorektora ds. badań naukowych : Małopolskie Centrum Biotechnologii
dc.affiliationpl
Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biochemii Fizycznej
dc.affiliationpl
Szkoła Doktorska Nauk Ścisłych i Przyrodniczych
dc.contributor.authorpl
Obłoza, Magdalena - 180217
dc.contributor.authorpl
Milewska, Aleksandra - 115344
dc.contributor.authorpl
Botwina, Paweł - 205270
dc.contributor.authorpl
Szczepański, Artur - 165863
dc.contributor.authorpl
Medaj, Aneta - 440745
dc.contributor.authorpl
Bonarek, Piotr - 127398
dc.contributor.authorpl
Szczubiałka, Krzysztof - 132218
dc.contributor.authorpl
Pyrć, Krzysztof - 161470
dc.contributor.authorpl
Nowakowska, Maria - 131048
dc.date.accessioned
2024-02-16T14:01:06Z
dc.date.available
2024-02-16T14:01:06Z
dc.date.issuedpl
2024
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 5435-5437
dc.description.numberpl
5
dc.description.physicalpl
5426-5437
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
16
dc.identifier.doipl
10.1021/acsami.3c13893
dc.identifier.eissnpl
1944-8252
dc.identifier.issnpl
1944-8244
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/327224
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
inne
dc.subject.enpl
Zika virus
dc.subject.enpl
antiviral
dc.subject.enpl
polymer
dc.subject.enpl
poly(sodium4-styrenesulfonate)
dc.subject.enpl
curcumin
dc.subject.enpl
flavivirus
dc.subtypepl
Article
dc.titlepl
Curcumin-poly(sodium 4-styrenesulfonate) conjugates as potent Zika virus entry inhibitors
dc.title.journalpl
ACS Applied Materials & Interfaces
dc.typepl
JournalArticle
dspace.entity.type
Publication

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