Short- and long-term outcomes of continuous-flow left ventricular assist device therapy in 79 patients with end-stage heart failure

2020
journal article
article
1
cris.lastimport.wos2024-04-10T02:55:51Z
dc.abstract.enIntroduction An increasing number of patients with end‑stage heart failure, along with a shortage of heart donors, necessitates the use of mechanical circulatory support. Objecti ves This single‑center retrospective study evaluated short- and long‑term outcomes of continuous‑flow left ventricular assist device (CF‑LVAD) therapy in patients with end‑stage heart failure. Patient s and methods We collected and assessed data of 79 patients (77 men, 2 women; mean age, 50.3 years; mean INTERMACS profile, 3.1) implanted with a CF‑LVAD between 2009 and 2017 (HeartMate 3 in 19 patients [24%]; HeartMate 2 in 9 [11.4%]; and HeartWare in 51 [64.6%]). Result s The mean time on CF‑LVAD support was 604 days (range, 1–1758 days). There were 2 device exchanges due to pump thrombosis and 1 explantation due to heart regeneration; 9 patients (11.4%) underwent heart transplant. Stroke (nondisabling, 48%) occurred in 27.8% of patients (ischemic in 9 patients; hemorrhagic, in 14; both types, in 1) despite the standardized anticoagulation regimen. Major gastrointestinal bleeding and pump thrombosis were reported in 13 patients (16.5%), while 18 patients (22.8%) developed driveline infections (recurrent in 15 patients [19%]). Hemorrhagic stroke and bacteremia had a negative impact on survival. Hemorrhagic stroke was the main cause of death. Survival probability was 0.9 at 1 month and 0.81, 0.71, 0.61, and 0.53 at 1, 2, 3, and 4 years, respectively. Conclusions Although CF‑LVAD support is associated with substantial adverse events, they do not significantly affect mortality (except hemorrhagic stroke and bacteremia). Novel devices seem to overcome these limitations, but larger studies are needed to support these findings.pl
dc.affiliationWydział Lekarski : Klinika Chirurgii Ogólnej, Onkologicznej i Gastroenterologicznejpl
dc.cm.date2021-02-15
dc.cm.id100458
dc.contributor.authorBien, Agnieszkapl
dc.contributor.authorKalinowski, Mariuszpl
dc.contributor.authorPacholewicz, Jerzypl
dc.contributor.authorMałyszek-Tumidajewicz, Justynapl
dc.contributor.authorWaszak, Jacekpl
dc.contributor.authorCopik, Izabelapl
dc.contributor.authorKowalczuk-Wieteska, Anettapl
dc.contributor.authorZakliczyński, Michałpl
dc.contributor.authorPrzybyłowski, Piotr - 133230 pl
dc.contributor.authorZembala, Marianpl
dc.contributor.authorZembala, Marianpl
dc.date.accessioned2021-02-15T01:20:47Z
dc.date.available2021-02-15T01:20:47Z
dc.date.issued2020pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number7-8pl
dc.description.physical589-597pl
dc.description.points100
dc.description.versionostateczna wersja wydawcy
dc.description.volume130pl
dc.identifier.doi10.20452/pamw.15362pl
dc.identifier.eissn1897-9483pl
dc.identifier.issn0032-3772pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/263766
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-SA
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enadverse eventspl
dc.subject.enend‑stage heart failurepl
dc.subject.enleft ventricular assist devicepl
dc.subject.ensurvivalpl
dc.subtypeArticlepl
dc.titleShort- and long-term outcomes of continuous-flow left ventricular assist device therapy in 79 patients with end-stage heart failurepl
dc.title.journalPolskie Archiwum Medycyny Wewnętrznej = Polish Archives of Internal Medicinepl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T02:55:51Z
dc.abstract.enpl
Introduction An increasing number of patients with end‑stage heart failure, along with a shortage of heart donors, necessitates the use of mechanical circulatory support. Objecti ves This single‑center retrospective study evaluated short- and long‑term outcomes of continuous‑flow left ventricular assist device (CF‑LVAD) therapy in patients with end‑stage heart failure. Patient s and methods We collected and assessed data of 79 patients (77 men, 2 women; mean age, 50.3 years; mean INTERMACS profile, 3.1) implanted with a CF‑LVAD between 2009 and 2017 (HeartMate 3 in 19 patients [24%]; HeartMate 2 in 9 [11.4%]; and HeartWare in 51 [64.6%]). Result s The mean time on CF‑LVAD support was 604 days (range, 1–1758 days). There were 2 device exchanges due to pump thrombosis and 1 explantation due to heart regeneration; 9 patients (11.4%) underwent heart transplant. Stroke (nondisabling, 48%) occurred in 27.8% of patients (ischemic in 9 patients; hemorrhagic, in 14; both types, in 1) despite the standardized anticoagulation regimen. Major gastrointestinal bleeding and pump thrombosis were reported in 13 patients (16.5%), while 18 patients (22.8%) developed driveline infections (recurrent in 15 patients [19%]). Hemorrhagic stroke and bacteremia had a negative impact on survival. Hemorrhagic stroke was the main cause of death. Survival probability was 0.9 at 1 month and 0.81, 0.71, 0.61, and 0.53 at 1, 2, 3, and 4 years, respectively. Conclusions Although CF‑LVAD support is associated with substantial adverse events, they do not significantly affect mortality (except hemorrhagic stroke and bacteremia). Novel devices seem to overcome these limitations, but larger studies are needed to support these findings.
dc.affiliationpl
Wydział Lekarski : Klinika Chirurgii Ogólnej, Onkologicznej i Gastroenterologicznej
dc.cm.date
2021-02-15
dc.cm.id
100458
dc.contributor.authorpl
Bien, Agnieszka
dc.contributor.authorpl
Kalinowski, Mariusz
dc.contributor.authorpl
Pacholewicz, Jerzy
dc.contributor.authorpl
Małyszek-Tumidajewicz, Justyna
dc.contributor.authorpl
Waszak, Jacek
dc.contributor.authorpl
Copik, Izabela
dc.contributor.authorpl
Kowalczuk-Wieteska, Anetta
dc.contributor.authorpl
Zakliczyński, Michał
dc.contributor.authorpl
Przybyłowski, Piotr - 133230
dc.contributor.authorpl
Zembala, Marian
dc.contributor.authorpl
Zembala, Marian
dc.date.accessioned
2021-02-15T01:20:47Z
dc.date.available
2021-02-15T01:20:47Z
dc.date.issuedpl
2020
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
7-8
dc.description.physicalpl
589-597
dc.description.points
100
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
130
dc.identifier.doipl
10.20452/pamw.15362
dc.identifier.eissnpl
1897-9483
dc.identifier.issnpl
0032-3772
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/263766
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-SA
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
adverse events
dc.subject.enpl
end‑stage heart failure
dc.subject.enpl
left ventricular assist device
dc.subject.enpl
survival
dc.subtypepl
Article
dc.titlepl
Short- and long-term outcomes of continuous-flow left ventricular assist device therapy in 79 patients with end-stage heart failure
dc.title.journalpl
Polskie Archiwum Medycyny Wewnętrznej = Polish Archives of Internal Medicine
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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