Central nervous system lymphoma in a 3-year-old male suffering from a severe juvenile xanthogranuloma : the usefulness of perfusion weighted imaging and diffusion weighted imaging in the diagnostics of pediatric brain tumors

2015
journal article
article
8
cris.lastimport.wos2024-04-10T02:56:31Z
dc.abstract.enBackground: Primary Central Nervous System Lymphomas (PCNSLs) are rare, malignant brain tumors derived from lymphocytes B. Juvenile xanthogranuloma (JXG) is a non-Langerhans histiocytic cell disorder in children which mostly affects the skin. Rare fatalities have been reported in extracutaneous manifestation. Brain magnetic resonance imaging (MRI) is a method of choice in the diagnostics of all neoplastic CNS lesions. Perfusion weighted imaging (PWI) and diffusion weighted imaging (DWI) allow for more detailed analysis of brain tumors including the rate of neoangiogenesis and cellularity. We presented a pediatric patient suffering from JXG with CNS involvement and the role of brain MRI including DWI and PWI in the evaluation of brain focal lesions. Case Report: A 3-year-old male with severe JXG underwent two stem cell transplantations with a development of neurological complications. The patient underwent emergency CT and MRI which revealed a non-specific enhancing focal brain lesion. In DWI it showed restricted diffusion while PWI revealed low values of rCBV and the signal intensity curve returning above the baseline level. Advanced MRI techniques such as DWI and PWI suggested PCNSL. Stereotactic biopsy confirmed PCNSL due to Ebstein-Barr virus reactivation. Conclusions: The use of advanced MRI sequences is important to differentiate brain lesions in pediatric patients. The use of PWI and DWI facilitated the diagnosis of PCNSL. It is important to remember that PCNSLs show a very typical pattern of changes visualized with MRI such as: usually strong homogenous enhancement, restricted diffusion and low perfusion.pl
dc.contributor.authorNeska-Matuszewska, Małgorzatapl
dc.contributor.authorZimny, Annapl
dc.contributor.authorKałwak, Krzysztofpl
dc.contributor.authorSąsiadek, Marek J.pl
dc.date.accessioned2017-07-06T09:48:37Z
dc.date.available2017-07-06T09:48:37Z
dc.date.issued2015pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 35pl
dc.description.physical31-35pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume80pl
dc.identifier.doi10.12659/PJR.892106pl
dc.identifier.eissn1899-0967pl
dc.identifier.issn1733-134Xpl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/42436
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode*
dc.share.typeotwarte czasopismo
dc.subject.encentral nervous system neoplasmspl
dc.subject.endiffusion magnetic resonance imagingpl
dc.subject.enlymphomapl
dc.subject.enb-cellpl
dc.subject.enmagnetic resonance angiographypl
dc.subject.enmagnetic resonance imagingpl
dc.subject.enxanthogranulomapl
dc.subject.enjuvenilepl
dc.subtypeArticlepl
dc.titleCentral nervous system lymphoma in a 3-year-old male suffering from a severe juvenile xanthogranuloma : the usefulness of perfusion weighted imaging and diffusion weighted imaging in the diagnostics of pediatric brain tumorspl
dc.title.journalPolish Journal of Radiologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T02:56:31Z
dc.abstract.enpl
Background: Primary Central Nervous System Lymphomas (PCNSLs) are rare, malignant brain tumors derived from lymphocytes B. Juvenile xanthogranuloma (JXG) is a non-Langerhans histiocytic cell disorder in children which mostly affects the skin. Rare fatalities have been reported in extracutaneous manifestation. Brain magnetic resonance imaging (MRI) is a method of choice in the diagnostics of all neoplastic CNS lesions. Perfusion weighted imaging (PWI) and diffusion weighted imaging (DWI) allow for more detailed analysis of brain tumors including the rate of neoangiogenesis and cellularity. We presented a pediatric patient suffering from JXG with CNS involvement and the role of brain MRI including DWI and PWI in the evaluation of brain focal lesions. Case Report: A 3-year-old male with severe JXG underwent two stem cell transplantations with a development of neurological complications. The patient underwent emergency CT and MRI which revealed a non-specific enhancing focal brain lesion. In DWI it showed restricted diffusion while PWI revealed low values of rCBV and the signal intensity curve returning above the baseline level. Advanced MRI techniques such as DWI and PWI suggested PCNSL. Stereotactic biopsy confirmed PCNSL due to Ebstein-Barr virus reactivation. Conclusions: The use of advanced MRI sequences is important to differentiate brain lesions in pediatric patients. The use of PWI and DWI facilitated the diagnosis of PCNSL. It is important to remember that PCNSLs show a very typical pattern of changes visualized with MRI such as: usually strong homogenous enhancement, restricted diffusion and low perfusion.
dc.contributor.authorpl
Neska-Matuszewska, Małgorzata
dc.contributor.authorpl
Zimny, Anna
dc.contributor.authorpl
Kałwak, Krzysztof
dc.contributor.authorpl
Sąsiadek, Marek J.
dc.date.accessioned
2017-07-06T09:48:37Z
dc.date.available
2017-07-06T09:48:37Z
dc.date.issuedpl
2015
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 35
dc.description.physicalpl
31-35
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
80
dc.identifier.doipl
10.12659/PJR.892106
dc.identifier.eissnpl
1899-0967
dc.identifier.issnpl
1733-134X
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/42436
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode
dc.share.type
otwarte czasopismo
dc.subject.enpl
central nervous system neoplasms
dc.subject.enpl
diffusion magnetic resonance imaging
dc.subject.enpl
lymphoma
dc.subject.enpl
b-cell
dc.subject.enpl
magnetic resonance angiography
dc.subject.enpl
magnetic resonance imaging
dc.subject.enpl
xanthogranuloma
dc.subject.enpl
juvenile
dc.subtypepl
Article
dc.titlepl
Central nervous system lymphoma in a 3-year-old male suffering from a severe juvenile xanthogranuloma : the usefulness of perfusion weighted imaging and diffusion weighted imaging in the diagnostics of pediatric brain tumors
dc.title.journalpl
Polish Journal of Radiology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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