Assessment of brain phenylalanine dynamics in phenylketonuria patients

2006
journal article
article
dc.abstract.enBackground: Phenylketonuria (PKU) is the most common inborn error of metabolism in man. Brain phenylalanine kinetics can determine neurological treatment outcome in phenylketonuria. The aim of our study was to test a simplified magnetic resonance spectroscopy method for assessment of brain phenylalanine dynamics in PKU patients. Material/Methods: Brain phenylalanine concentration (measured by means of magnetic resonance spectroscopy) and blood phenylalanine concentrations changes occurring within 24 hours after oral phenylalanine loading were analyzed in 5 PKU patients. Results/Conclusions: The brain/blood phenylalanine ratio in 3 persons with normal intelligence was lower than in 2 with borderline intelligence or mild mental retardation. In our opinion the proposed method could be useful for assessment of brain phenylalanine dynamics in PKU patients.pl
dc.affiliationWydział Lekarski : Instytut Pediatriipl
dc.contributor.authorBik-Multanowski, Mirosław - 128777 pl
dc.contributor.authorPietrzyk, Jacek J. - 133150 pl
dc.contributor.authorPasowicz, Mieczyslawpl
dc.contributor.authorBanys, R. Pawelpl
dc.date.accession2019-07-10pl
dc.date.accessioned2019-07-10T15:05:39Z
dc.date.available2019-07-10T15:05:39Z
dc.date.issued2006pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 25pl
dc.description.number2pl
dc.description.physical24-25pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume71pl
dc.identifier.articleid451183pl
dc.identifier.eissn1899-0967pl
dc.identifier.issn1733-134Xpl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/78843
dc.identifier.weblinkhttp://archiwum.inforadiologia.pl/download/index/idArt/451183.htmlpl
dc.languageengpl
dc.language.containerpolpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enblood-brain barrierpl
dc.subject.enamino acid transportpl
dc.subtypeArticlepl
dc.titleAssessment of brain phenylalanine dynamics in phenylketonuria patientspl
dc.title.alternativeOcena dynamiki mózgowego stężenia fenyloalaniny u pacjentów z fenyloketonuriąpl
dc.title.journalPolish Journal of Radiologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Background: Phenylketonuria (PKU) is the most common inborn error of metabolism in man. Brain phenylalanine kinetics can determine neurological treatment outcome in phenylketonuria. The aim of our study was to test a simplified magnetic resonance spectroscopy method for assessment of brain phenylalanine dynamics in PKU patients. Material/Methods: Brain phenylalanine concentration (measured by means of magnetic resonance spectroscopy) and blood phenylalanine concentrations changes occurring within 24 hours after oral phenylalanine loading were analyzed in 5 PKU patients. Results/Conclusions: The brain/blood phenylalanine ratio in 3 persons with normal intelligence was lower than in 2 with borderline intelligence or mild mental retardation. In our opinion the proposed method could be useful for assessment of brain phenylalanine dynamics in PKU patients.
dc.affiliationpl
Wydział Lekarski : Instytut Pediatrii
dc.contributor.authorpl
Bik-Multanowski, Mirosław - 128777
dc.contributor.authorpl
Pietrzyk, Jacek J. - 133150
dc.contributor.authorpl
Pasowicz, Mieczyslaw
dc.contributor.authorpl
Banys, R. Pawel
dc.date.accessionpl
2019-07-10
dc.date.accessioned
2019-07-10T15:05:39Z
dc.date.available
2019-07-10T15:05:39Z
dc.date.issuedpl
2006
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 25
dc.description.numberpl
2
dc.description.physicalpl
24-25
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
71
dc.identifier.articleidpl
451183
dc.identifier.eissnpl
1899-0967
dc.identifier.issnpl
1733-134X
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/78843
dc.identifier.weblinkpl
http://archiwum.inforadiologia.pl/download/index/idArt/451183.html
dc.languagepl
eng
dc.language.containerpl
pol
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
blood-brain barrier
dc.subject.enpl
amino acid transport
dc.subtypepl
Article
dc.titlepl
Assessment of brain phenylalanine dynamics in phenylketonuria patients
dc.title.alternativepl
Ocena dynamiki mózgowego stężenia fenyloalaniny u pacjentów z fenyloketonurią
dc.title.journalpl
Polish Journal of Radiology
dc.typepl
JournalArticle
dspace.entity.type
Publication

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