Additional value of [18F]FDG PET/CT in detection of suspected malignancy in patients with paraneoplastic neurological syndromes having negative results of conventional radiological imaging

2022
journal article
article
2
dc.abstract.enBackground: Paraneoplastic neurological syndromes (PNS) affecting the CNS (central nervous system) are rare, presenting in less than 1% of all those with cancer. The pathogenesis of paraneoplastic neurological syndromes is not fully understood, but it is presumed to result from an immune attack on the underlying malignancy. The presence of different types of onconeural antibodies may occur in different tumors and can lead to different clinical manifestations, making the early detection of cancers challenging. Aim: An evaluation of [18F]FDG PET/CT in neoplastic tumor detection in patients with paraneoplastic neurological syndromes having negative or unremarkable results of conventional radiological imaging. Methods: Among all patients diagnosed with paraneoplastic neurological syndromes in the Neurology Department in 2016–2020, 15 patients with unremarkable conventional radiological findings who underwent [18F]FDG PET/CT were included in the study. Results: [18F]FDG PET/CT enabled localization of suspected malignancy in 53% (8 of 15) of PNS cases with previous unremarkable conventional radiological findings. Conclusion: [18F]FDG PET/CT may be considered as a useful tool for neoplastic tumor detection in patients with paraneoplastic neurological syndromes, accelerating the diagnostic process and enabling faster initiation of appropriate treatment.pl
dc.affiliationWydział Lekarski : Klinika Endokrynologiipl
dc.affiliationWydział Lekarski : Zakład Neurogenetykipl
dc.affiliationWydział Lekarski : Klinika Neurologiipl
dc.affiliationWydział Nauk o Zdrowiu : Instytut Fizjoterapiipl
dc.cm.id107514
dc.cm.idOmegaUJCMf309ddfa80f147e8a468bcf418501165pl
dc.contributor.authorOpalińska, Marta - 152452 pl
dc.contributor.authorSowa-Staszczak, Anna - 354560 pl
dc.contributor.authorWężyk, Kamil - 414089 pl
dc.contributor.authorJagiełła, Jeremiasz - 141402 pl
dc.contributor.authorSłowik, Agnieszka - 133430 pl
dc.contributor.authorHubalewska-Dydejczyk, Alicja - 129732 pl
dc.date.accession2022-03-18pl
dc.date.accessioned2022-03-17T13:31:49Z
dc.date.available2022-03-17T13:31:49Z
dc.date.issued2022pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number6pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume11pl
dc.identifier.articleid1537pl
dc.identifier.doi10.3390/jcm11061537pl
dc.identifier.eissn2077-0383pl
dc.identifier.issn2077-0383pl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/289363
dc.identifier.weblinkhttps://www.mdpi.com/2077-0383/11/6/1537pl
dc.languageengpl
dc.language.containerengpl
dc.pbn.affiliationDziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licenceCC-BY
dc.rights.uri*
dc.share.typeOtwarte czasopismo
dc.subtypeArticlepl
dc.titleAdditional value of [18F]FDG PET/CT in detection of suspected malignancy in patients with paraneoplastic neurological syndromes having negative results of conventional radiological imagingpl
dc.title.journalJournal of Clinical Medicinepl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Background: Paraneoplastic neurological syndromes (PNS) affecting the CNS (central nervous system) are rare, presenting in less than 1% of all those with cancer. The pathogenesis of paraneoplastic neurological syndromes is not fully understood, but it is presumed to result from an immune attack on the underlying malignancy. The presence of different types of onconeural antibodies may occur in different tumors and can lead to different clinical manifestations, making the early detection of cancers challenging. Aim: An evaluation of [18F]FDG PET/CT in neoplastic tumor detection in patients with paraneoplastic neurological syndromes having negative or unremarkable results of conventional radiological imaging. Methods: Among all patients diagnosed with paraneoplastic neurological syndromes in the Neurology Department in 2016–2020, 15 patients with unremarkable conventional radiological findings who underwent [18F]FDG PET/CT were included in the study. Results: [18F]FDG PET/CT enabled localization of suspected malignancy in 53% (8 of 15) of PNS cases with previous unremarkable conventional radiological findings. Conclusion: [18F]FDG PET/CT may be considered as a useful tool for neoplastic tumor detection in patients with paraneoplastic neurological syndromes, accelerating the diagnostic process and enabling faster initiation of appropriate treatment.
dc.affiliationpl
Wydział Lekarski : Klinika Endokrynologii
dc.affiliationpl
Wydział Lekarski : Zakład Neurogenetyki
dc.affiliationpl
Wydział Lekarski : Klinika Neurologii
dc.affiliationpl
Wydział Nauk o Zdrowiu : Instytut Fizjoterapii
dc.cm.id
107514
dc.cm.idOmegapl
UJCMf309ddfa80f147e8a468bcf418501165
dc.contributor.authorpl
Opalińska, Marta - 152452
dc.contributor.authorpl
Sowa-Staszczak, Anna - 354560
dc.contributor.authorpl
Wężyk, Kamil - 414089
dc.contributor.authorpl
Jagiełła, Jeremiasz - 141402
dc.contributor.authorpl
Słowik, Agnieszka - 133430
dc.contributor.authorpl
Hubalewska-Dydejczyk, Alicja - 129732
dc.date.accessionpl
2022-03-18
dc.date.accessioned
2022-03-17T13:31:49Z
dc.date.available
2022-03-17T13:31:49Z
dc.date.issuedpl
2022
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
6
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
11
dc.identifier.articleidpl
1537
dc.identifier.doipl
10.3390/jcm11061537
dc.identifier.eissnpl
2077-0383
dc.identifier.issnpl
2077-0383
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/289363
dc.identifier.weblinkpl
https://www.mdpi.com/2077-0383/11/6/1537
dc.languagepl
eng
dc.language.containerpl
eng
dc.pbn.affiliation
Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
CC-BY
dc.rights.uri*
dc.share.type
Otwarte czasopismo
dc.subtypepl
Article
dc.titlepl
Additional value of [18F]FDG PET/CT in detection of suspected malignancy in patients with paraneoplastic neurological syndromes having negative results of conventional radiological imaging
dc.title.journalpl
Journal of Clinical Medicine
dc.typepl
JournalArticle
dspace.entity.type
Publication

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