In this study we examined the hypothesis that depression and anxiety may mediate the relationship betweenpersonality traits and both positive and negative psychotic-like experiences (PLEs) in healthy adults. TheCommunity Assessment of Psychic Experiences (CAPE) scale, Temperament and Character Inventory (TCI),Beck Depression Inventory (BDI) and State and Trait Anxiety Inventory (STAI) were administered to 492healthy individuals. Multiple stepwise regression and mediation analyses were performed to examine whetherdepressive and anxiety symptoms influence the relationship between the TCI dimensions and positive andnegative PLEs. Self-transcendence, persistence, novelty-seeking and self-directedness significantly predictedpositive PLEs; self-directedness and harm avoidance were predictable for negative PLEs. Self-transcendence,self-directedness, persistence and harm avoidance also predicted the distress caused by positive PLEs, whereasself-directedness and harm avoidance predicted distress raised by negative PLEs. Depressive symptoms and thestate of anxiety partially mediated the linkage between self-directedness and positive PLEs, and between self-directedness, harm avoidance and negative PLEs. Our findings confirm that the personality pattern influencesboth positive and negative PLEs as well as distress caused by experiencing positive and negative PLEs, and theyindicate that certain personality traits may influence the development of PLEs via the emotional pathway ofheightened depression and anxiety.