Functional rearrangement of language areas in patients with tumors of the central nervous system using functional magnetic resonance imaging

2012
journal article
article
cris.lastimport.wos2024-04-10T03:17:32Z
dc.abstract.enBackground: The aim of this study was to determine the reorganization of the language areas in patients with tumors located near speech centers using functional magnetic resonance imaging (fMRI). Material/Methods: fMRI was performed prior to the surgical treatment of 11 right-handed patients with tumors located close to the Broca's or Wernicke's areas of the left hemisphere. The analysis included a record of the activity in four regions of interest (ROIs): Broca's and Wernicke's areas, and their anatomic homologues in the right hemisphere. For each patient a regional lateralization index was calculated separately for Broca's area versus its right-hemisphere homolog and Wernicke's area versus its right-hemisphere homolog. The results were correlated with the histopathological type of the tumor and its size. Results: Our fMRI examinations showed activation of the Broca's area in the right hemisphere in 3/4 cases of low grade gliomas (LGG) localized in the left frontal lobe. In one case of the high grade glioma (HGG) only the left hemisphere Broca's area was activated (LI=1). Activation in Wernicke's area in both hemispheres was obtained irrespective of the size and histological type of the tumor. All tumors localized in the left temporal lobe were HGG. We obtained activation only in the right hemisphere Wernicke's area in 4/5 of the cases. In 4/5 of the cases activation in Broca's area was present- in 2 cases in the left hemisphere, in 1 case in the right hemisphere and in 1 case bilateral. Conclusions: The presence of a neoplastic lesion in close topographic relationship to language areas induces their functional reorganization. fMRI is an useful method for determination of language areas localization in pre-operative planning. HGG tumors localized near Wernicke's area lead to transfer its function to the healthy hemisphere and/or to decreased activity in the affected hemisphere.pl
dc.contributor.authorKośla, Katarzynapl
dc.contributor.authorPfajfer, Lucjanpl
dc.contributor.authorBryszewski, Bartoszpl
dc.contributor.authorJaskólski, Dariuszpl
dc.contributor.authorStefańczyk, Ludomirpl
dc.contributor.authorMajos, Agatapl
dc.date.accessioned2017-09-08T10:35:00Z
dc.date.available2017-09-08T10:35:00Z
dc.date.issued2012pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 44-45pl
dc.description.number3pl
dc.description.physical39-45pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume77pl
dc.identifier.doi10.12659/PJR.883373pl
dc.identifier.eissn1899-0967pl
dc.identifier.issn1733-134Xpl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/43979
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode*
dc.share.typeotwarte czasopismo
dc.subject.enneuroplasticitypl
dc.subject.enlanguage lateralizationpl
dc.subject.enfunctional magnetic resonance imagingpl
dc.subject.enBrocapl
dc.subject.enWernickepl
dc.subtypeArticlepl
dc.titleFunctional rearrangement of language areas in patients with tumors of the central nervous system using functional magnetic resonance imagingpl
dc.title.journalPolish Journal of Radiologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T03:17:32Z
dc.abstract.enpl
Background: The aim of this study was to determine the reorganization of the language areas in patients with tumors located near speech centers using functional magnetic resonance imaging (fMRI). Material/Methods: fMRI was performed prior to the surgical treatment of 11 right-handed patients with tumors located close to the Broca's or Wernicke's areas of the left hemisphere. The analysis included a record of the activity in four regions of interest (ROIs): Broca's and Wernicke's areas, and their anatomic homologues in the right hemisphere. For each patient a regional lateralization index was calculated separately for Broca's area versus its right-hemisphere homolog and Wernicke's area versus its right-hemisphere homolog. The results were correlated with the histopathological type of the tumor and its size. Results: Our fMRI examinations showed activation of the Broca's area in the right hemisphere in 3/4 cases of low grade gliomas (LGG) localized in the left frontal lobe. In one case of the high grade glioma (HGG) only the left hemisphere Broca's area was activated (LI=1). Activation in Wernicke's area in both hemispheres was obtained irrespective of the size and histological type of the tumor. All tumors localized in the left temporal lobe were HGG. We obtained activation only in the right hemisphere Wernicke's area in 4/5 of the cases. In 4/5 of the cases activation in Broca's area was present- in 2 cases in the left hemisphere, in 1 case in the right hemisphere and in 1 case bilateral. Conclusions: The presence of a neoplastic lesion in close topographic relationship to language areas induces their functional reorganization. fMRI is an useful method for determination of language areas localization in pre-operative planning. HGG tumors localized near Wernicke's area lead to transfer its function to the healthy hemisphere and/or to decreased activity in the affected hemisphere.
dc.contributor.authorpl
Kośla, Katarzyna
dc.contributor.authorpl
Pfajfer, Lucjan
dc.contributor.authorpl
Bryszewski, Bartosz
dc.contributor.authorpl
Jaskólski, Dariusz
dc.contributor.authorpl
Stefańczyk, Ludomir
dc.contributor.authorpl
Majos, Agata
dc.date.accessioned
2017-09-08T10:35:00Z
dc.date.available
2017-09-08T10:35:00Z
dc.date.issuedpl
2012
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 44-45
dc.description.numberpl
3
dc.description.physicalpl
39-45
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
77
dc.identifier.doipl
10.12659/PJR.883373
dc.identifier.eissnpl
1899-0967
dc.identifier.issnpl
1733-134X
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/43979
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode
dc.share.type
otwarte czasopismo
dc.subject.enpl
neuroplasticity
dc.subject.enpl
language lateralization
dc.subject.enpl
functional magnetic resonance imaging
dc.subject.enpl
Broca
dc.subject.enpl
Wernicke
dc.subtypepl
Article
dc.titlepl
Functional rearrangement of language areas in patients with tumors of the central nervous system using functional magnetic resonance imaging
dc.title.journalpl
Polish Journal of Radiology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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