GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects

2012
journal article
article
5
cris.lastimport.wos2024-04-10T03:12:11Z
dc.abstract.enLesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system. We have evaluated the linkage disequilibrium patterns and haplotype frequencies of GABRG1 and GABRA2 genes in 133 alcoholics divided according to Lesch's typology and in 145 matched controls. Besides several relationships at a threshold of statistical significance, we found no significant differences in the haplotype distribution of these genes between alcoholics and controls. Lesch's typology may not be related with the genotype of alcoholics – at least in terms of genes with an established role in the development of dependency.pl
dc.affiliationWydział Zarządzania i Komunikacji Społecznej : Instytut Psychologii Stosowanejpl
dc.affiliationPion Kanclerza : Pion Zastępcy kanclerza ds. ogólnychpl
dc.contributor.authorKaniewska-Grzywacz, Anna - 128620 pl
dc.contributor.authorMałecka, Iwonapl
dc.contributor.authorKorostyński, Michałpl
dc.contributor.authorPrzewłocki, Ryszard - 131566 pl
dc.contributor.authorBieńkowski, Przemysławpl
dc.contributor.authorSamochowiec, Jerzypl
dc.date.accession2019-04-09pl
dc.date.accessioned2014-09-24T15:57:13Z
dc.date.available2014-09-24T15:57:13Z
dc.date.issued2012pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number2pl
dc.description.physical357-361pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume8pl
dc.identifier.doi10.5114/aoms.2012.28565pl
dc.identifier.eissn1896-9151pl
dc.identifier.issn1734-1922pl
dc.identifier.projectROD UJ / Ppl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/1267
dc.identifier.weblinkhttps://www.termedia.pl/Clinical-research-GABA-A-receptor-genes-do-not-play-a-role-in-genetics-of-Lesch-s-typology-in-Caucasian-subjects,19,18564,0,1.htmlpl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-SA
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enalcohol dependencepl
dc.subject.enGABApl
dc.subject.engeneticspl
dc.subject.enLesch's typologypl
dc.subtypeArticlepl
dc.titleGABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjectspl
dc.title.journalArchives of Medical Sciencepl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T03:12:11Z
dc.abstract.enpl
Lesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system. We have evaluated the linkage disequilibrium patterns and haplotype frequencies of GABRG1 and GABRA2 genes in 133 alcoholics divided according to Lesch's typology and in 145 matched controls. Besides several relationships at a threshold of statistical significance, we found no significant differences in the haplotype distribution of these genes between alcoholics and controls. Lesch's typology may not be related with the genotype of alcoholics – at least in terms of genes with an established role in the development of dependency.
dc.affiliationpl
Wydział Zarządzania i Komunikacji Społecznej : Instytut Psychologii Stosowanej
dc.affiliationpl
Pion Kanclerza : Pion Zastępcy kanclerza ds. ogólnych
dc.contributor.authorpl
Kaniewska-Grzywacz, Anna - 128620
dc.contributor.authorpl
Małecka, Iwona
dc.contributor.authorpl
Korostyński, Michał
dc.contributor.authorpl
Przewłocki, Ryszard - 131566
dc.contributor.authorpl
Bieńkowski, Przemysław
dc.contributor.authorpl
Samochowiec, Jerzy
dc.date.accessionpl
2019-04-09
dc.date.accessioned
2014-09-24T15:57:13Z
dc.date.available
2014-09-24T15:57:13Z
dc.date.issuedpl
2012
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
2
dc.description.physicalpl
357-361
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
8
dc.identifier.doipl
10.5114/aoms.2012.28565
dc.identifier.eissnpl
1896-9151
dc.identifier.issnpl
1734-1922
dc.identifier.projectpl
ROD UJ / P
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/1267
dc.identifier.weblinkpl
https://www.termedia.pl/Clinical-research-GABA-A-receptor-genes-do-not-play-a-role-in-genetics-of-Lesch-s-typology-in-Caucasian-subjects,19,18564,0,1.html
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-SA
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
alcohol dependence
dc.subject.enpl
GABA
dc.subject.enpl
genetics
dc.subject.enpl
Lesch's typology
dc.subtypepl
Article
dc.titlepl
GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects
dc.title.journalpl
Archives of Medical Science
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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