Evaluation of gastric emptying in patients with chronic renal failure on continuous ambulatory peritoneal dialysis using -solid meal

2004
journal article
article
dc.abstract.enBACKGROUND: Continuous ambulatory peritoneal dialysis (CAPD) is an alternative to the hemodialysis mode of terminal renal failure treatment. Nutritional status impairment is common among patients with end-stage renal disease, and its laboratory surrogates predict increased morbidity and mortality risk in patients on chronic haemodialysis or peritoneal dialyses. The aetiology of malnutrition is multifactorial and delayed gastric emptying is also considered to be a significant factor. The aim of this study was to estimate the direct influence of indwelled dialysate in the peritoneal cavity on gastric emptying in patients treated with CAPD. MATERIAL AND METHODS: the study group included 20 patients (9 males, 11 females) aged 50,1 ± 11 years (range: 39–75 years) with chronic renal failure treated with CAPD for 18.4 ± 14.7 months. All patients were non-diabetic and had no other than chronic uraemia co-morbidity known to influence autonomic nervous system function and gastric motility. The control group included 15 healthy volunteers matched by age, sex and body weight. Dialysis adequacy parameters were calculated based on 24-hour urine and dialysate collections. Gastric emptying was estimated with dynamic abdominal scintigraphy. We compared the results of gastric emptying tests performed in dialysed patients with and without dialysate liquid in the peritoneal cavity and related the values to those of the control subjects. RESULTS: In the study group, weekly values of dialysis parameters were within the ranges considered satisfactory in terms of uraemia control. All parameters of gastric emptying were significantly delayed and prolonged in terminal renal failure patients, but the results have shown no significant differences between those with and without indwelling dialysate. CONCLUSIONS: Based on the results we conclude that gastric emptying in subjects with chronic renal failure treated with CAPD is markedly delayed compared to healthy subjects. There was no significant effect of indwelling dialysate in the peritoneal cavity on gastric emptying rates found, based on the observation that its removal was not associated with any noticeable improvement of gastric emptying. The data strongly contraindicate the theory of peritoneal dialysate volume being the cause of this reversible disorder and indicate that the role of other possible factors leading to the development of gastropathy in those patients should be investigated.pl
dc.affiliationWydział Lekarski : Klinika Nefrologiipl
dc.affiliationWydział Lekarski : Klinika Endokrynologiipl
dc.contributor.authorHubalewska-Dydejczyk, Alicja - 129732 pl
dc.contributor.authorStompór, Tomaszpl
dc.contributor.authorPłaczkiewicz, Ewapl
dc.contributor.authorStaszczak, Annapl
dc.contributor.authorHuszno, Bohdan - 352434 pl
dc.contributor.authorSułowicz, Władysław - 133536 pl
dc.contributor.authorSzybiński, Zbigniewpl
dc.date.accession2020-07-06pl
dc.date.accessioned2020-07-06T12:58:39Z
dc.date.available2020-07-06T12:58:39Z
dc.date.issued2004pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 30pl
dc.description.number1pl
dc.description.physical27-30pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume7pl
dc.identifier.eissn1644-4345pl
dc.identifier.issn1506-9680pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/165268
dc.identifier.weblinkhttps://journals.viamedica.pl/nuclear_medicine_review/article/view/15361/12185pl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enperitoneal dialysispl
dc.subject.engastric emptyingpl
dc.subject.enscintigraphypl
dc.subject.en99mTc-solid mealpl
dc.subtypeArticlepl
dc.titleEvaluation of gastric emptying in patients with chronic renal failure on continuous ambulatory peritoneal dialysis using $^{99m}Tc$-solid mealpl
dc.title.journalNuclear Medicine Reviewpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
BACKGROUND: Continuous ambulatory peritoneal dialysis (CAPD) is an alternative to the hemodialysis mode of terminal renal failure treatment. Nutritional status impairment is common among patients with end-stage renal disease, and its laboratory surrogates predict increased morbidity and mortality risk in patients on chronic haemodialysis or peritoneal dialyses. The aetiology of malnutrition is multifactorial and delayed gastric emptying is also considered to be a significant factor. The aim of this study was to estimate the direct influence of indwelled dialysate in the peritoneal cavity on gastric emptying in patients treated with CAPD. MATERIAL AND METHODS: the study group included 20 patients (9 males, 11 females) aged 50,1 ± 11 years (range: 39–75 years) with chronic renal failure treated with CAPD for 18.4 ± 14.7 months. All patients were non-diabetic and had no other than chronic uraemia co-morbidity known to influence autonomic nervous system function and gastric motility. The control group included 15 healthy volunteers matched by age, sex and body weight. Dialysis adequacy parameters were calculated based on 24-hour urine and dialysate collections. Gastric emptying was estimated with dynamic abdominal scintigraphy. We compared the results of gastric emptying tests performed in dialysed patients with and without dialysate liquid in the peritoneal cavity and related the values to those of the control subjects. RESULTS: In the study group, weekly values of dialysis parameters were within the ranges considered satisfactory in terms of uraemia control. All parameters of gastric emptying were significantly delayed and prolonged in terminal renal failure patients, but the results have shown no significant differences between those with and without indwelling dialysate. CONCLUSIONS: Based on the results we conclude that gastric emptying in subjects with chronic renal failure treated with CAPD is markedly delayed compared to healthy subjects. There was no significant effect of indwelling dialysate in the peritoneal cavity on gastric emptying rates found, based on the observation that its removal was not associated with any noticeable improvement of gastric emptying. The data strongly contraindicate the theory of peritoneal dialysate volume being the cause of this reversible disorder and indicate that the role of other possible factors leading to the development of gastropathy in those patients should be investigated.
dc.affiliationpl
Wydział Lekarski : Klinika Nefrologii
dc.affiliationpl
Wydział Lekarski : Klinika Endokrynologii
dc.contributor.authorpl
Hubalewska-Dydejczyk, Alicja - 129732
dc.contributor.authorpl
Stompór, Tomasz
dc.contributor.authorpl
Płaczkiewicz, Ewa
dc.contributor.authorpl
Staszczak, Anna
dc.contributor.authorpl
Huszno, Bohdan - 352434
dc.contributor.authorpl
Sułowicz, Władysław - 133536
dc.contributor.authorpl
Szybiński, Zbigniew
dc.date.accessionpl
2020-07-06
dc.date.accessioned
2020-07-06T12:58:39Z
dc.date.available
2020-07-06T12:58:39Z
dc.date.issuedpl
2004
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 30
dc.description.numberpl
1
dc.description.physicalpl
27-30
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
7
dc.identifier.eissnpl
1644-4345
dc.identifier.issnpl
1506-9680
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/165268
dc.identifier.weblinkpl
https://journals.viamedica.pl/nuclear_medicine_review/article/view/15361/12185
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
peritoneal dialysis
dc.subject.enpl
gastric emptying
dc.subject.enpl
scintigraphy
dc.subject.enpl
99mTc-solid meal
dc.subtypepl
Article
dc.titlepl
Evaluation of gastric emptying in patients with chronic renal failure on continuous ambulatory peritoneal dialysis using $^{99m}Tc$-solid meal
dc.title.journalpl
Nuclear Medicine Review
dc.typepl
JournalArticle
dspace.entity.type
Publication

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