Multirate delivery of multiple therapeutic agents from metal-organic frameworks

2014
journal article
article
dc.abstract.otherThe highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.pl
dc.affiliationWydział Chemii : Zakład Chemii Nieorganicznejpl
dc.contributor.authorMcKinlay, Alistair C.pl
dc.contributor.authorAllan, Phoebe K.pl
dc.contributor.authorRenouf, Catherine L.pl
dc.contributor.authorDuncan, Morven J.pl
dc.contributor.authorWheatley, Paul S.pl
dc.contributor.authorWarrender, Steward J.pl
dc.contributor.authorDawson, Danielpl
dc.contributor.authorAshbrook, Sharon E.pl
dc.contributor.authorGil, Barbara - 128059 pl
dc.contributor.authorMarszałek, Bartosz - 115142 pl
dc.contributor.authorDüren, Tinapl
dc.contributor.authorWilliams, Jenifer J.pl
dc.contributor.authorCharrier, Cedricpl
dc.contributor.authorMercer, Derry K.pl
dc.contributor.authorTeat, Simon J.pl
dc.contributor.authorMorris, Russell E.pl
dc.date.accession2019-02-14pl
dc.date.accessioned2015-06-17T09:44:12Z
dc.date.available2015-06-17T09:44:12Z
dc.date.issued2014pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number12pl
dc.description.publication0,9pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume2pl
dc.identifier.articleid124108pl
dc.identifier.doi10.1063/1.4903290pl
dc.identifier.eissn2166-532Xpl
dc.identifier.projectROD UJ / Ppl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/9691
dc.identifier.weblinkhttps://aip.scitation.org/doi/pdf/10.1063/1.4903290?class=pdfpl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 3.0 Polska*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/legalcode*
dc.share.typeotwarte czasopismo
dc.subtypeArticlepl
dc.titleMultirate delivery of multiple therapeutic agents from metal-organic frameworkspl
dc.title.journalAPL Materialspl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.otherpl
The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.
dc.affiliationpl
Wydział Chemii : Zakład Chemii Nieorganicznej
dc.contributor.authorpl
McKinlay, Alistair C.
dc.contributor.authorpl
Allan, Phoebe K.
dc.contributor.authorpl
Renouf, Catherine L.
dc.contributor.authorpl
Duncan, Morven J.
dc.contributor.authorpl
Wheatley, Paul S.
dc.contributor.authorpl
Warrender, Steward J.
dc.contributor.authorpl
Dawson, Daniel
dc.contributor.authorpl
Ashbrook, Sharon E.
dc.contributor.authorpl
Gil, Barbara - 128059
dc.contributor.authorpl
Marszałek, Bartosz - 115142
dc.contributor.authorpl
Düren, Tina
dc.contributor.authorpl
Williams, Jenifer J.
dc.contributor.authorpl
Charrier, Cedric
dc.contributor.authorpl
Mercer, Derry K.
dc.contributor.authorpl
Teat, Simon J.
dc.contributor.authorpl
Morris, Russell E.
dc.date.accessionpl
2019-02-14
dc.date.accessioned
2015-06-17T09:44:12Z
dc.date.available
2015-06-17T09:44:12Z
dc.date.issuedpl
2014
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
12
dc.description.publicationpl
0,9
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
2
dc.identifier.articleidpl
124108
dc.identifier.doipl
10.1063/1.4903290
dc.identifier.eissnpl
2166-532X
dc.identifier.projectpl
ROD UJ / P
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/9691
dc.identifier.weblinkpl
https://aip.scitation.org/doi/pdf/10.1063/1.4903290?class=pdf
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 3.0 Polska
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/3.0/legalcode
dc.share.type
otwarte czasopismo
dc.subtypepl
Article
dc.titlepl
Multirate delivery of multiple therapeutic agents from metal-organic frameworks
dc.title.journalpl
APL Materials
dc.typepl
JournalArticle
dspace.entity.type
Publication

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