Synteza i badania oddziaływania z albuminą N,N-dimetyloaminobenzylowej pochodnej tiosemikarbazonu i jej kompleksu z rutenem(II)

2013
journal article
article
dc.abstract.enPrevious studies have shown that some thiosemicarbazones have antitumor activity as inhibitors of ribonucleotide reductase and their reactivity can be enhanced by coordination to Ru ion. The following paper describes the synthesis of N,N-p-dimethylaminbenzaldehyde thiosemicarbazone and its Ru(II) complex. In addition, the interaction of the obtained compounds with albumin was carried out using fluorescence spectroscopy. It has been shown that coordination of ligand to ruthenium decrease its reactivity towards albumin and therefore the better bioavailability is expected.pl
dc.affiliationWydział Chemii : Zakład Chemii Nieorganicznejpl
dc.contributor.authorŁomzik, Michał - 149678 pl
dc.contributor.authorBrindell, Małgorzata - 127426 pl
dc.date.accession2019-06-11pl
dc.date.accessioned2015-06-17T06:43:20Z
dc.date.available2015-06-17T06:43:20Z
dc.date.issued2013pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalArt. w 2 wersjach językowych: tekst w jęz. pol. (s. 91-94) i ang. (s. 95-98)pl
dc.description.number2pl
dc.description.physical91-98pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume67pl
dc.identifier.issn0009-2886pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/9656
dc.identifier.weblinkhttp://yadda.icm.edu.pl/baztech/element/bwmeta1.element.baztech-article-BPP2-0025-0094?q=bwmeta1.element.baztech-volume-0009-2886-chemik-2013-vol__67_nr_2;1&qt=CHILDREN-STATELESSpl
dc.identifier.weblinkhttp://www.chemikinternational.com/year-2013/year-2013-issue-2/synthesis-and-interaction-with-albumin-of-nn-dimethylaminbenzyl-derivative-of-thiosemicarbazone-and-its-rutheniumii-complex-lomzik-m-brindell-m/pl
dc.languagepolpl
dc.language.containerpolpl
dc.rights.licenceOTHER
dc.share.typeinne
dc.subtypeArticlepl
dc.titleSynteza i badania oddziaływania z albuminą N,N-dimetyloaminobenzylowej pochodnej tiosemikarbazonu i jej kompleksu z rutenem(II)pl
dc.title.alternativeSynthesis and interaction with albumin of N,N-dimethylaminbenzyl derivative of thiosemicarbazone and its ruthenium(II) complexpl
dc.title.journalChemikpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Previous studies have shown that some thiosemicarbazones have antitumor activity as inhibitors of ribonucleotide reductase and their reactivity can be enhanced by coordination to Ru ion. The following paper describes the synthesis of N,N-p-dimethylaminbenzaldehyde thiosemicarbazone and its Ru(II) complex. In addition, the interaction of the obtained compounds with albumin was carried out using fluorescence spectroscopy. It has been shown that coordination of ligand to ruthenium decrease its reactivity towards albumin and therefore the better bioavailability is expected.
dc.affiliationpl
Wydział Chemii : Zakład Chemii Nieorganicznej
dc.contributor.authorpl
Łomzik, Michał - 149678
dc.contributor.authorpl
Brindell, Małgorzata - 127426
dc.date.accessionpl
2019-06-11
dc.date.accessioned
2015-06-17T06:43:20Z
dc.date.available
2015-06-17T06:43:20Z
dc.date.issuedpl
2013
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Art. w 2 wersjach językowych: tekst w jęz. pol. (s. 91-94) i ang. (s. 95-98)
dc.description.numberpl
2
dc.description.physicalpl
91-98
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
67
dc.identifier.issnpl
0009-2886
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/9656
dc.identifier.weblinkpl
http://yadda.icm.edu.pl/baztech/element/bwmeta1.element.baztech-article-BPP2-0025-0094?q=bwmeta1.element.baztech-volume-0009-2886-chemik-2013-vol__67_nr_2;1&qt=CHILDREN-STATELESS
dc.identifier.weblinkpl
http://www.chemikinternational.com/year-2013/year-2013-issue-2/synthesis-and-interaction-with-albumin-of-nn-dimethylaminbenzyl-derivative-of-thiosemicarbazone-and-its-rutheniumii-complex-lomzik-m-brindell-m/
dc.languagepl
pol
dc.language.containerpl
pol
dc.rights.licence
OTHER
dc.share.type
inne
dc.subtypepl
Article
dc.titlepl
Synteza i badania oddziaływania z albuminą N,N-dimetyloaminobenzylowej pochodnej tiosemikarbazonu i jej kompleksu z rutenem(II)
dc.title.alternativepl
Synthesis and interaction with albumin of N,N-dimethylaminbenzyl derivative of thiosemicarbazone and its ruthenium(II) complex
dc.title.journalpl
Chemik
dc.typepl
JournalArticle
dspace.entity.type
Publication

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