dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexes

2014
journal article
article
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dc.abstract.enDual-mode MRI contrast agents consisting of superparamagnetic iron oxide nanoparticle (SPION) cores and gadolinium ions associated with the ionic chitosan protecting layer were synthesized and studied. Gadolinium ions were introduced into the coating layer via direct complex formation on the nanoparticles surface, covalent attachment or electrostatically driven deposition of the preformed Gd complex. The modified SPIONs having hydrodynamic diameters ca. 100 nm form stable, well-defined dispersions in water and have excellent magnetic properties. Physiochemical prop- erties of those new materials were characterized using e.g., FTIR spectroscopy, dynamic light scattering, X-ray fluorescence, TEM, and vibrating sample mag- netometry. They behave as superparamagnetics and shorten both T 1 and T 2 proton relaxation times, thus influencing both r 1 and r 2 relaxivity values that reach 53.7 and 375.5 mM - 1 s - 1 , respectively, at 15 MHz. The obtained materials can be considered as highly effective contrast agents for low-field MRI, particu- larly useful at permanent magnet-based scanners.pl
dc.affiliationWydział Chemii : Zakład Chemii Fizycznej i Elektrochemiipl
dc.contributor.authorSzpak, Agnieszka - 103704 pl
dc.contributor.authorFiejdasz, Sylwia - 103693 pl
dc.contributor.authorPrendota, Witoldpl
dc.contributor.authorStrączek, Tomaszpl
dc.contributor.authorKapusta, Czesławpl
dc.contributor.authorSzmyd, Januszpl
dc.contributor.authorNowakowska, Maria - 131048 pl
dc.contributor.authorZapotoczny, Szczepan - 132863 pl
dc.date.accession2019-02-15pl
dc.date.accessioned2015-06-12T07:16:52Z
dc.date.available2015-06-12T07:16:52Z
dc.date.issued2014pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.admin[AB] Fiejdasz, Sylwia 50000141pl
dc.description.number11pl
dc.description.physical2678 (1-11)pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume16pl
dc.identifier.doi10.1007/s11051-014-2678-6pl
dc.identifier.eissn1572-896Xpl
dc.identifier.issn1388-0764pl
dc.identifier.projectROD UJ / Ppl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/9487
dc.identifier.weblinkhttps://link.springer.com/content/pdf/10.1007%2Fs11051-014-2678-6.pdfpl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeinne
dc.subject.ensuperparamagnetic nanoparticlespl
dc.subject.engadoliniumpl
dc.subject.enSPIONpl
dc.subject.enmagnetic resonance imagingpl
dc.subject.enchitosanpl
dc.subject.enrelaxivitypl
dc.subject.encomposite nanoparticlespl
dc.subtypeArticlepl
dc.title$T_{1}-T_{2}$ dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexespl
dc.title.journalJournal of Nanoparticle Researchpl
dc.typeJournalArticlepl
dspace.entity.typePublication
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