Intra-arterial thrombolytic therapy in the acute ischemic stroke

2008
journal article
article
dc.abstract.enBackground: To evaluate the clinical efficacy and safety of local intra-arterial thrombolysis with rt-Pa in patients suffering from MCA acute brain infarction within 6 hours of the onset of symptoms Material/Methods: Forty one patients with acute ischemic stroke of the middle cerebral artery (MCA) were qualified to the treatment (up to 6 hours after the beginning of the symptoms). Patient qualification was based on clinical examination, computed tomography (CT) and digital subtraction angiography (DSA). CT follow-up was performed after 24 hours and between 7-10 days. Continuous infusion of rt-Pa with a final dose of 40mg was administered. The patients were evaluated before, at discharge and 90 days after the procedure on the basis of modified Rankin and NIHSS scores. Results: At the primary outcome, 22 (53%) of the patients achieved modified Rankin scores of 2 or less after 90 days. The secondary clinical outcome at 90 day follow-up: (NIHSS score £1) - 9 (22%) of the patients, (NIHSS score ³50% decrease) - 24 (59%). A rate of recanalization was achieved in 76% of patients. Symptomatic hemorrhages occurred in 4 (10%). There were no deaths in the treated group after thrombolysis up to the time of discharge; however, the mortality during the 90-day follow-up period was 7%. Conclusions: Intra-arterial thrombolysis with the use of rt-Pa, in the treatment of ischemic brain stroke within 6 hours after the onset considerably improved the clinical condition of patients after 90 days.pl
dc.contributor.authorPoncyljusz, Wojciechpl
dc.contributor.authorFalkowski, Aleksanderpl
dc.contributor.authorCebula, Ewapl
dc.contributor.authorSagan, Leszekpl
dc.contributor.authorJeżewski, Dariuszpl
dc.contributor.authorRzewuski, Krzysztofpl
dc.contributor.authorRać, Monikapl
dc.contributor.authorWalecka, Annapl
dc.contributor.authorKojder, Ireneuszpl
dc.date.accession2019-05-20pl
dc.date.accessioned2019-05-20T05:55:31Z
dc.date.available2019-05-20T05:55:31Z
dc.date.issued2008pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 10-11pl
dc.description.number4pl
dc.description.physical7-11pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume73pl
dc.identifier.articleid878361pl
dc.identifier.eissn1899-0967pl
dc.identifier.issn1733-134Xpl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/75138
dc.identifier.weblinkhttp://archiwum.inforadiologia.pl/download/index/idArt/878361.htmlpl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enlocal intra-arterial thrombolysispl
dc.subject.enacute ischemic strokepl
dc.subtypeArticlepl
dc.titleIntra-arterial thrombolytic therapy in the acute ischemic strokepl
dc.title.journalPolish Journal of Radiologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Background: To evaluate the clinical efficacy and safety of local intra-arterial thrombolysis with rt-Pa in patients suffering from MCA acute brain infarction within 6 hours of the onset of symptoms Material/Methods: Forty one patients with acute ischemic stroke of the middle cerebral artery (MCA) were qualified to the treatment (up to 6 hours after the beginning of the symptoms). Patient qualification was based on clinical examination, computed tomography (CT) and digital subtraction angiography (DSA). CT follow-up was performed after 24 hours and between 7-10 days. Continuous infusion of rt-Pa with a final dose of 40mg was administered. The patients were evaluated before, at discharge and 90 days after the procedure on the basis of modified Rankin and NIHSS scores. Results: At the primary outcome, 22 (53%) of the patients achieved modified Rankin scores of 2 or less after 90 days. The secondary clinical outcome at 90 day follow-up: (NIHSS score £1) - 9 (22%) of the patients, (NIHSS score ³50% decrease) - 24 (59%). A rate of recanalization was achieved in 76% of patients. Symptomatic hemorrhages occurred in 4 (10%). There were no deaths in the treated group after thrombolysis up to the time of discharge; however, the mortality during the 90-day follow-up period was 7%. Conclusions: Intra-arterial thrombolysis with the use of rt-Pa, in the treatment of ischemic brain stroke within 6 hours after the onset considerably improved the clinical condition of patients after 90 days.
dc.contributor.authorpl
Poncyljusz, Wojciech
dc.contributor.authorpl
Falkowski, Aleksander
dc.contributor.authorpl
Cebula, Ewa
dc.contributor.authorpl
Sagan, Leszek
dc.contributor.authorpl
Jeżewski, Dariusz
dc.contributor.authorpl
Rzewuski, Krzysztof
dc.contributor.authorpl
Rać, Monika
dc.contributor.authorpl
Walecka, Anna
dc.contributor.authorpl
Kojder, Ireneusz
dc.date.accessionpl
2019-05-20
dc.date.accessioned
2019-05-20T05:55:31Z
dc.date.available
2019-05-20T05:55:31Z
dc.date.issuedpl
2008
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 10-11
dc.description.numberpl
4
dc.description.physicalpl
7-11
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
73
dc.identifier.articleidpl
878361
dc.identifier.eissnpl
1899-0967
dc.identifier.issnpl
1733-134X
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/75138
dc.identifier.weblinkpl
http://archiwum.inforadiologia.pl/download/index/idArt/878361.html
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
local intra-arterial thrombolysis
dc.subject.enpl
acute ischemic stroke
dc.subtypepl
Article
dc.titlepl
Intra-arterial thrombolytic therapy in the acute ischemic stroke
dc.title.journalpl
Polish Journal of Radiology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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