Value of MRI in differentiating adrenal masses : quantitative analysis of tumor signal intensity

2008
journal article
article
dc.abstract.enBackground: Several reports show that MR imaging, especially using the chemical-shift sequence, provides highly reliable differentiation of adrenal adenomas from non-adenomas. The aim of the study was to evaluate the ability of MRI to distinguish adenomas from other adrenal masses using quantitative analysis of the tumors' signal intensity. Material/Methods: Fifty-four patients with 57 adrenal masses underwent MRI. The tumors were determined during surgery as pheochromocytomas (8), metastases (5), adrenal cortical carcinoma (1), and adenomas (24). Nineteen masses were diagnosed as adenomas on the basis of stability on imaging followup and the absence of clinical and endocrinological dysfunction. Chemical-shift-weighted images (T1TFE sequence) and T2-weighted images (TSE sequence) were used for quantitative analysis which included the T2 index (adrenal mass SI to liver SI ratio) and the CSI ratio (the adrenal mass SI on the in-phase image minus the adrenal mass SI on the opposed-phase image divided by the adrenal mass SI on the in-phase image). Statistical analysis was performed with the Mann-Whitney U test. Receiver operating characteristic (ROC) analysis of the calculated parameters was performed. Results: Significant differences in T2 index between adenomas (mean: 1.43±0.50) and pheochromocytomas (2.66±0.67) as well as between metastases (1.64±0.22) and pheochromocytomas were noted (p<0.05). The Mann-Whitney U test revealed no significant difference in T2 index for adenomas vs. metastases (p=0.1). The CSI ratio was significantly different for adenomas (0.36±0.18) vs. pheochromocytomas (-0.15±0.16) as well as for adenomas vs. metastases (-0.23±0.26). No significant difference occurred in the CSI ratios between pheochromocytomas and metastases. ROC analysis showed that the discriminatory ability of adenoma diagnosis with the CSI ratio is better than with the T2 index (areas under the ROC curve: 0.980 vs. 0.867). Conclusions: Quantitative methods using signal intensity ratios and indexes calculated from MR images are helpful in differentiating adrenal adenomas from non-adenomas. In the presented investigation the CSI ratio appeared much more reliable than the T2 index as a quantitative means of distinguishing adenomas from other adrenal tumors.pl
dc.contributor.authorZielonko, Joannapl
dc.contributor.authorStudniarek, Michałpl
dc.contributor.authorRzepko, Robertpl
dc.contributor.authorBabińska, Annapl
dc.contributor.authorSiekierska-Hellmann, Małgorzatapl
dc.date.accession2019-05-16pl
dc.date.accessioned2019-05-16T11:52:25Z
dc.date.available2019-05-16T11:52:25Z
dc.date.issued2008pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 12pl
dc.description.number2pl
dc.description.physical7-12pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume73pl
dc.identifier.articleid857099pl
dc.identifier.eissn1899-0967pl
dc.identifier.issn1733-134Xpl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/74920
dc.identifier.weblinkhttp://archiwum.inforadiologia.pl/download/index/idArt/857099.htmlpl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enadrenal massespl
dc.subject.enmagnetic resonancepl
dc.subject.enchemical shift imagingpl
dc.subtypeArticlepl
dc.titleValue of MRI in differentiating adrenal masses : quantitative analysis of tumor signal intensitypl
dc.title.journalPolish Journal of Radiologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Background: Several reports show that MR imaging, especially using the chemical-shift sequence, provides highly reliable differentiation of adrenal adenomas from non-adenomas. The aim of the study was to evaluate the ability of MRI to distinguish adenomas from other adrenal masses using quantitative analysis of the tumors' signal intensity. Material/Methods: Fifty-four patients with 57 adrenal masses underwent MRI. The tumors were determined during surgery as pheochromocytomas (8), metastases (5), adrenal cortical carcinoma (1), and adenomas (24). Nineteen masses were diagnosed as adenomas on the basis of stability on imaging followup and the absence of clinical and endocrinological dysfunction. Chemical-shift-weighted images (T1TFE sequence) and T2-weighted images (TSE sequence) were used for quantitative analysis which included the T2 index (adrenal mass SI to liver SI ratio) and the CSI ratio (the adrenal mass SI on the in-phase image minus the adrenal mass SI on the opposed-phase image divided by the adrenal mass SI on the in-phase image). Statistical analysis was performed with the Mann-Whitney U test. Receiver operating characteristic (ROC) analysis of the calculated parameters was performed. Results: Significant differences in T2 index between adenomas (mean: 1.43±0.50) and pheochromocytomas (2.66±0.67) as well as between metastases (1.64±0.22) and pheochromocytomas were noted (p<0.05). The Mann-Whitney U test revealed no significant difference in T2 index for adenomas vs. metastases (p=0.1). The CSI ratio was significantly different for adenomas (0.36±0.18) vs. pheochromocytomas (-0.15±0.16) as well as for adenomas vs. metastases (-0.23±0.26). No significant difference occurred in the CSI ratios between pheochromocytomas and metastases. ROC analysis showed that the discriminatory ability of adenoma diagnosis with the CSI ratio is better than with the T2 index (areas under the ROC curve: 0.980 vs. 0.867). Conclusions: Quantitative methods using signal intensity ratios and indexes calculated from MR images are helpful in differentiating adrenal adenomas from non-adenomas. In the presented investigation the CSI ratio appeared much more reliable than the T2 index as a quantitative means of distinguishing adenomas from other adrenal tumors.
dc.contributor.authorpl
Zielonko, Joanna
dc.contributor.authorpl
Studniarek, Michał
dc.contributor.authorpl
Rzepko, Robert
dc.contributor.authorpl
Babińska, Anna
dc.contributor.authorpl
Siekierska-Hellmann, Małgorzata
dc.date.accessionpl
2019-05-16
dc.date.accessioned
2019-05-16T11:52:25Z
dc.date.available
2019-05-16T11:52:25Z
dc.date.issuedpl
2008
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 12
dc.description.numberpl
2
dc.description.physicalpl
7-12
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
73
dc.identifier.articleidpl
857099
dc.identifier.eissnpl
1899-0967
dc.identifier.issnpl
1733-134X
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/74920
dc.identifier.weblinkpl
http://archiwum.inforadiologia.pl/download/index/idArt/857099.html
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
adrenal masses
dc.subject.enpl
magnetic resonance
dc.subject.enpl
chemical shift imaging
dc.subtypepl
Article
dc.titlepl
Value of MRI in differentiating adrenal masses : quantitative analysis of tumor signal intensity
dc.title.journalpl
Polish Journal of Radiology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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