Clinical validity of MR based program for analysis of fluid/brain index of posterior cranial fossa structures in patients with spinocerebellar ataxia

2008
journal article
article
dc.abstract.enBackground: Spinocerebellar ataxia type 1 (SCA1) and type 2 (SCA2) belong to the group of neurodegenerative disorders of autosomal dominant inheritance, genetically and clinically heterogeneous, caused by CAG trinucleotide repeat expansion, which leads to productions of protein carrying the abnormal polyglutamine chain (polyQ). Molecular abnormalities cause degenerative changes - atrophy of posterior cranial fossa structures. The clinical symptoms typical of this disorder include progressive gait and limb ataxia, dysarthria, occulomotor disturbances, pyramidal tract and peripheral nerves involvement. The aim of the study is to evaluate the usefulness of a computer program prepared in our department for volumetric measurements of posterior cranial fossa structures (the pons, vermis and cerebellar hemispheres) in a group of SCA patients. Material/Methods: MR examinations of 22 patients suffering from SCA were used to calculate the value of fluid/brain index of posterior cranial fossa structures and compared with the results of group of 10 healthy volunteers. The degree of atrophy of posterior cranial fossa structures can be objectively evaluated by special volumetric measurements. Results: We found fluid/brain index (FBI) of posterior cranial fossa structures in group of SCA patients to vary from 0.1411 to 0.3929 (mean 0.2456 SD±0.601). Conclusions: 1. MR-based calculation of fluid/brain index of posterior fossa structures is a valuable tool for morphological assessment of SCA-related changes in brain structures. 2. The presented software enables objective evaluation of the course and stage of posterior fossa structures atrophy. 3. Our self-made computer program to calculate the fluid/brain index of posterior cranial fossa structures is easy to use on a personal computer - it is a good tool in everyday radiological practice.pl
dc.contributor.authorBogusławska, Romanapl
dc.contributor.authorRakowicz, Mariapl
dc.contributor.authorRola, Rafałpl
dc.contributor.authorSawicka, Beatapl
dc.contributor.authorKrawczyk, Renatapl
dc.contributor.authorMakulec, Arturpl
dc.contributor.authorZdzienicka, Elżbietapl
dc.contributor.authorPoniatowska, Renatapl
dc.contributor.authorRyterski, Jarosławpl
dc.contributor.authorSułek, Annapl
dc.contributor.authorWalecki, Jerzypl
dc.contributor.authorLechowicz, Waldemarpl
dc.date.accession2019-04-29pl
dc.date.accessioned2019-04-29T12:48:56Z
dc.date.available2019-04-29T12:48:56Z
dc.date.issued2008pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliiogr. s. 38-39pl
dc.description.number1pl
dc.description.physical32-39pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume73pl
dc.identifier.articleid677304pl
dc.identifier.eissn1899-0967pl
dc.identifier.issn1733-134Xpl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/73888
dc.identifier.weblinkhttp://archiwum.inforadiologia.pl/download/index/idArt/677304.htmlpl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enMR volumetric measurementspl
dc.subject.enspinocerebellar ataxia SCA1pl
dc.subject.enspinocerebellar ataxia SCA2pl
dc.subtypeArticlepl
dc.titleClinical validity of MR based program for analysis of fluid/brain index of posterior cranial fossa structures in patients with spinocerebellar ataxiapl
dc.title.journalPolish Journal of Radiologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Background: Spinocerebellar ataxia type 1 (SCA1) and type 2 (SCA2) belong to the group of neurodegenerative disorders of autosomal dominant inheritance, genetically and clinically heterogeneous, caused by CAG trinucleotide repeat expansion, which leads to productions of protein carrying the abnormal polyglutamine chain (polyQ). Molecular abnormalities cause degenerative changes - atrophy of posterior cranial fossa structures. The clinical symptoms typical of this disorder include progressive gait and limb ataxia, dysarthria, occulomotor disturbances, pyramidal tract and peripheral nerves involvement. The aim of the study is to evaluate the usefulness of a computer program prepared in our department for volumetric measurements of posterior cranial fossa structures (the pons, vermis and cerebellar hemispheres) in a group of SCA patients. Material/Methods: MR examinations of 22 patients suffering from SCA were used to calculate the value of fluid/brain index of posterior cranial fossa structures and compared with the results of group of 10 healthy volunteers. The degree of atrophy of posterior cranial fossa structures can be objectively evaluated by special volumetric measurements. Results: We found fluid/brain index (FBI) of posterior cranial fossa structures in group of SCA patients to vary from 0.1411 to 0.3929 (mean 0.2456 SD±0.601). Conclusions: 1. MR-based calculation of fluid/brain index of posterior fossa structures is a valuable tool for morphological assessment of SCA-related changes in brain structures. 2. The presented software enables objective evaluation of the course and stage of posterior fossa structures atrophy. 3. Our self-made computer program to calculate the fluid/brain index of posterior cranial fossa structures is easy to use on a personal computer - it is a good tool in everyday radiological practice.
dc.contributor.authorpl
Bogusławska, Romana
dc.contributor.authorpl
Rakowicz, Maria
dc.contributor.authorpl
Rola, Rafał
dc.contributor.authorpl
Sawicka, Beata
dc.contributor.authorpl
Krawczyk, Renata
dc.contributor.authorpl
Makulec, Artur
dc.contributor.authorpl
Zdzienicka, Elżbieta
dc.contributor.authorpl
Poniatowska, Renata
dc.contributor.authorpl
Ryterski, Jarosław
dc.contributor.authorpl
Sułek, Anna
dc.contributor.authorpl
Walecki, Jerzy
dc.contributor.authorpl
Lechowicz, Waldemar
dc.date.accessionpl
2019-04-29
dc.date.accessioned
2019-04-29T12:48:56Z
dc.date.available
2019-04-29T12:48:56Z
dc.date.issuedpl
2008
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliiogr. s. 38-39
dc.description.numberpl
1
dc.description.physicalpl
32-39
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
73
dc.identifier.articleidpl
677304
dc.identifier.eissnpl
1899-0967
dc.identifier.issnpl
1733-134X
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/73888
dc.identifier.weblinkpl
http://archiwum.inforadiologia.pl/download/index/idArt/677304.html
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
MR volumetric measurements
dc.subject.enpl
spinocerebellar ataxia SCA1
dc.subject.enpl
spinocerebellar ataxia SCA2
dc.subtypepl
Article
dc.titlepl
Clinical validity of MR based program for analysis of fluid/brain index of posterior cranial fossa structures in patients with spinocerebellar ataxia
dc.title.journalpl
Polish Journal of Radiology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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