Filamentous aggregates of tau proteins fulfil standard amyloid criteria provided by the fuzzy oil drop (FOD) model

2018
journal article
article
19
cris.lastimport.wos2024-04-09T21:28:42Z
dc.abstract.enAbnormal filamentous aggregates that are formed by tangled tau protein turn out to be classic amyloid fibrils, meeting all the criteria defined under the fuzzy oil drop model in the context of amyloid characterization. The model recognizes amyloids as linear structures where local hydrophobicity minima and maxima propagate in an alternating manner along the fibril’s long axis. This distribution of hydrophobicity differs greatly from the classic monocentric hydrophobic core observed in globular proteins. Rather than becoming a globule, the amyloid instead forms a ribbonlike (or cylindrical) structure.pl
dc.affiliationWydział Lekarski : Zakład Bioinformatyki i Telemedycynypl
dc.cm.id91352
dc.contributor.authorDułak, Dawidpl
dc.contributor.authorGadzała, Małgorzatapl
dc.contributor.authorBanach, Mateusz - 103003 pl
dc.contributor.authorPtak-Kaczor, Magdalena - 222421 pl
dc.contributor.authorWiśniowski, Zdzisław - 133792 pl
dc.contributor.authorKonieczny, Leszekpl
dc.contributor.authorRoterman-Konieczna, Irena - 133298 pl
dc.date.accessioned2019-03-20T12:24:32Z
dc.date.available2019-03-20T12:24:32Z
dc.date.issued2018pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number10pl
dc.description.points30pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume19pl
dc.identifier.articleid2910pl
dc.identifier.doi10.3390/ijms19102910pl
dc.identifier.eissn1422-0067pl
dc.identifier.issn1661-6596pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/70941
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.entau amyloidpl
dc.subject.enAlzheimer’s diseasepl
dc.subject.entauopathypl
dc.subtypeArticlepl
dc.titleFilamentous aggregates of tau proteins fulfil standard amyloid criteria provided by the fuzzy oil drop (FOD) modelpl
dc.title.journalInternational Journal of Molecular Sciencespl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T21:28:42Z
dc.abstract.enpl
Abnormal filamentous aggregates that are formed by tangled tau protein turn out to be classic amyloid fibrils, meeting all the criteria defined under the fuzzy oil drop model in the context of amyloid characterization. The model recognizes amyloids as linear structures where local hydrophobicity minima and maxima propagate in an alternating manner along the fibril’s long axis. This distribution of hydrophobicity differs greatly from the classic monocentric hydrophobic core observed in globular proteins. Rather than becoming a globule, the amyloid instead forms a ribbonlike (or cylindrical) structure.
dc.affiliationpl
Wydział Lekarski : Zakład Bioinformatyki i Telemedycyny
dc.cm.id
91352
dc.contributor.authorpl
Dułak, Dawid
dc.contributor.authorpl
Gadzała, Małgorzata
dc.contributor.authorpl
Banach, Mateusz - 103003
dc.contributor.authorpl
Ptak-Kaczor, Magdalena - 222421
dc.contributor.authorpl
Wiśniowski, Zdzisław - 133792
dc.contributor.authorpl
Konieczny, Leszek
dc.contributor.authorpl
Roterman-Konieczna, Irena - 133298
dc.date.accessioned
2019-03-20T12:24:32Z
dc.date.available
2019-03-20T12:24:32Z
dc.date.issuedpl
2018
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
10
dc.description.pointspl
30
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
19
dc.identifier.articleidpl
2910
dc.identifier.doipl
10.3390/ijms19102910
dc.identifier.eissnpl
1422-0067
dc.identifier.issnpl
1661-6596
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/70941
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
tau amyloid
dc.subject.enpl
Alzheimer’s disease
dc.subject.enpl
tauopathy
dc.subtypepl
Article
dc.titlepl
Filamentous aggregates of tau proteins fulfil standard amyloid criteria provided by the fuzzy oil drop (FOD) model
dc.title.journalpl
International Journal of Molecular Sciences
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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