Prognostic value of duration of untreated psychosis in long-term outcome of schizophrenia

2011
journal article
article
19
dc.abstract.enThe goal of this prognostic study was to investigate whether the duration of untreated psychosis (DUP) may have a prognostic value with regard to the further course of the illness. Material/Methods: Fifty-eight patients (77% of the original study group) diagnosed with DSM III schizophrenia and later re-diagnosed with DSM IV T-R were assessed at 4 time points. Number of relapses, average time of inpatient treatment, number of inpatient readmissions, and severity of psychopathological symptoms were assessed at 1-, 3-, 7- and 12-year follow-ups. DUP information was obtained by clinical interview with patients and their families. The severity of symptoms was assessed using BPRS-SA, UCLA version. Results: Increases in the number of relapses at follow-ups were more prominent in the group with a longer DUP (p<0.001). Decreases in the results of BPRS (symptom improvement) were more prominent in patients with a shorter DUP. The latter had significantly lower results than patients with a long DUP at each assessment except the index hospitalization (p equalled, respectively: 0.449; 0.002; 0.012; 0.034 and 0.014). Decreases in positive symptoms were greater in patients with a short DUP – significant at all except the 7-year follow-up (p equalled respectively: 0.230; <0.001; 0.011; 0.214; <0.001). Conclusions: 1) A positive correlation was found between DUP and the dynamics of general and positive symptoms and the number of relapses. 2) There was no significant relationship between DUP and the dynamics of negative symptoms, whereas the relationship between the time and number of re-hospitalizations was marginally significant.pl
dc.affiliationWydział Filozoficzny : Instytut Psychologiipl
dc.affiliationWydział Lekarskipl
dc.contributor.authorCechnicki, Andrzej - 128966 pl
dc.contributor.authorHanuszkiewicz, Igorpl
dc.contributor.authorPolczyk, Romuald - 131496 pl
dc.contributor.authorBielańska, Annapl
dc.date.accession2018-10-18pl
dc.date.accessioned2018-12-28T12:35:13Z
dc.date.available2018-12-28T12:35:13Z
dc.date.issued2011pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr s. 283pl
dc.description.number5pl
dc.description.physical277-283pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume17pl
dc.identifier.doi10.12659/MSM.881768pl
dc.identifier.eissn1643-3750pl
dc.identifier.issn1234-1010pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/64602
dc.identifier.weblinkhttps://www.medscimonit.com/download/index/idArt/881768pl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enschizophreniapl
dc.subject.encourse of illnesspl
dc.subject.enduration of untreated psychosispl
dc.subject.plschizofreniapl
dc.subject.plprzebieg chorobypl
dc.subject.plczas trwania nieleczonej psychozypl
dc.subtypeArticlepl
dc.titlePrognostic value of duration of untreated psychosis in long-term outcome of schizophreniapl
dc.title.journalMedical Science Monitorpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
The goal of this prognostic study was to investigate whether the duration of untreated psychosis (DUP) may have a prognostic value with regard to the further course of the illness. Material/Methods: Fifty-eight patients (77% of the original study group) diagnosed with DSM III schizophrenia and later re-diagnosed with DSM IV T-R were assessed at 4 time points. Number of relapses, average time of inpatient treatment, number of inpatient readmissions, and severity of psychopathological symptoms were assessed at 1-, 3-, 7- and 12-year follow-ups. DUP information was obtained by clinical interview with patients and their families. The severity of symptoms was assessed using BPRS-SA, UCLA version. Results: Increases in the number of relapses at follow-ups were more prominent in the group with a longer DUP (p<0.001). Decreases in the results of BPRS (symptom improvement) were more prominent in patients with a shorter DUP. The latter had significantly lower results than patients with a long DUP at each assessment except the index hospitalization (p equalled, respectively: 0.449; 0.002; 0.012; 0.034 and 0.014). Decreases in positive symptoms were greater in patients with a short DUP – significant at all except the 7-year follow-up (p equalled respectively: 0.230; <0.001; 0.011; 0.214; <0.001). Conclusions: 1) A positive correlation was found between DUP and the dynamics of general and positive symptoms and the number of relapses. 2) There was no significant relationship between DUP and the dynamics of negative symptoms, whereas the relationship between the time and number of re-hospitalizations was marginally significant.
dc.affiliationpl
Wydział Filozoficzny : Instytut Psychologii
dc.affiliationpl
Wydział Lekarski
dc.contributor.authorpl
Cechnicki, Andrzej - 128966
dc.contributor.authorpl
Hanuszkiewicz, Igor
dc.contributor.authorpl
Polczyk, Romuald - 131496
dc.contributor.authorpl
Bielańska, Anna
dc.date.accessionpl
2018-10-18
dc.date.accessioned
2018-12-28T12:35:13Z
dc.date.available
2018-12-28T12:35:13Z
dc.date.issuedpl
2011
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr s. 283
dc.description.numberpl
5
dc.description.physicalpl
277-283
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
17
dc.identifier.doipl
10.12659/MSM.881768
dc.identifier.eissnpl
1643-3750
dc.identifier.issnpl
1234-1010
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/64602
dc.identifier.weblinkpl
https://www.medscimonit.com/download/index/idArt/881768
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
schizophrenia
dc.subject.enpl
course of illness
dc.subject.enpl
duration of untreated psychosis
dc.subject.plpl
schizofrenia
dc.subject.plpl
przebieg choroby
dc.subject.plpl
czas trwania nieleczonej psychozy
dc.subtypepl
Article
dc.titlepl
Prognostic value of duration of untreated psychosis in long-term outcome of schizophrenia
dc.title.journalpl
Medical Science Monitor
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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