Early-life stress affects the structural and functional plasticity of the medial prefrontal cortex in adolescent rats

2013
journal article
article
115
dc.abstract.enEarly life experiences are crucial factors that shape brain development and function due to their ability to induce structural and functional plasticity. Among these experiences, early-life stress (ELS) is known to interfere with brain development and maturation, increasing the risk of future psychopathologies, including depression, anxiety, and personality disorders. Moreover, ELS may contribute to the emergence of these psychopathologies during adolescence. In this present study, we investigated the effects of ELS, in the form of maternal separation (MS), on the structural and functional plasticity of the medial prefrontal cortex (mPFC) and anxiety-like behavior in adolescent male rats. We found that the MS procedure resulted in disturbances in mother-pup interactions that lasted until weaning and were most strongly demonstrated by increases in nursing behavior. Moreover, MS caused atrophy of the basal dendritic tree and reduced spine density on both the apical and basal dendrites in layer II/III pyramidal neurons of the mPFC. The structural changes were accompanied by an impairment of long-term potentiation processes and increased expression of key proteins, specifically glutamate receptor 1, glutamate receptor 2, postsynaptic density protein 95, alphaCa^{2+}/calmodulin-dependent protein kinase II and alpha Ca2+/calmodulin-dependent protein kinase II phosphorylated at residue Thr305, that are engaged in long-term potentiation induction and maintenance in the mPFC. We also found that the MS animals were more anxious in the light/dark exploration test. The results of this study indicate that ELS has a significant impact on the structural and functional plasticity of the mPFC in adolescents. ELS-induced adaptive plasticity may underlie the pathomechanisms of some early-onset psychopathologies observed in adolescents.pl
dc.contributor.authorChocyk, Agnieszkapl
dc.contributor.authorBobula, Bartosz - 256764 pl
dc.contributor.authorDudys, Dorotapl
dc.contributor.authorPrzyborowska, Aleksandrapl
dc.contributor.authorMajcher-Maślanka, Iwonapl
dc.contributor.authorHess, Grzegorz - 128317 pl
dc.contributor.authorWędzony, Krzysztofpl
dc.date.accessioned2015-04-27T06:37:26Z
dc.date.available2015-04-27T06:37:26Z
dc.date.issued2013pl
dc.description.number1pl
dc.description.physical2089-2107pl
dc.description.volume38pl
dc.identifier.doi10.1111/ejn.12208pl
dc.identifier.eissn1460-9568pl
dc.identifier.issn0953-816Xpl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/5763
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licencebez licencji
dc.rights.uri*
dc.subject.enAMPA receptorspl
dc.subject.enCa^{2+}/calmodulin-dependent protein kinase IIpl
dc.subject.enlong-termpl
dc.subject.enpotentiationpl
dc.subject.enmaternal separationpl
dc.subject.enpostsynaptic density protein 95pl
dc.subtypeArticlepl
dc.titleEarly-life stress affects the structural and functional plasticity of the medial prefrontal cortex in adolescent ratspl
dc.title.journalEuropean Journal of Neurosciencepl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Early life experiences are crucial factors that shape brain development and function due to their ability to induce structural and functional plasticity. Among these experiences, early-life stress (ELS) is known to interfere with brain development and maturation, increasing the risk of future psychopathologies, including depression, anxiety, and personality disorders. Moreover, ELS may contribute to the emergence of these psychopathologies during adolescence. In this present study, we investigated the effects of ELS, in the form of maternal separation (MS), on the structural and functional plasticity of the medial prefrontal cortex (mPFC) and anxiety-like behavior in adolescent male rats. We found that the MS procedure resulted in disturbances in mother-pup interactions that lasted until weaning and were most strongly demonstrated by increases in nursing behavior. Moreover, MS caused atrophy of the basal dendritic tree and reduced spine density on both the apical and basal dendrites in layer II/III pyramidal neurons of the mPFC. The structural changes were accompanied by an impairment of long-term potentiation processes and increased expression of key proteins, specifically glutamate receptor 1, glutamate receptor 2, postsynaptic density protein 95, alphaCa^{2+}/calmodulin-dependent protein kinase II and alpha Ca2+/calmodulin-dependent protein kinase II phosphorylated at residue Thr305, that are engaged in long-term potentiation induction and maintenance in the mPFC. We also found that the MS animals were more anxious in the light/dark exploration test. The results of this study indicate that ELS has a significant impact on the structural and functional plasticity of the mPFC in adolescents. ELS-induced adaptive plasticity may underlie the pathomechanisms of some early-onset psychopathologies observed in adolescents.
dc.contributor.authorpl
Chocyk, Agnieszka
dc.contributor.authorpl
Bobula, Bartosz - 256764
dc.contributor.authorpl
Dudys, Dorota
dc.contributor.authorpl
Przyborowska, Aleksandra
dc.contributor.authorpl
Majcher-Maślanka, Iwona
dc.contributor.authorpl
Hess, Grzegorz - 128317
dc.contributor.authorpl
Wędzony, Krzysztof
dc.date.accessioned
2015-04-27T06:37:26Z
dc.date.available
2015-04-27T06:37:26Z
dc.date.issuedpl
2013
dc.description.numberpl
1
dc.description.physicalpl
2089-2107
dc.description.volumepl
38
dc.identifier.doipl
10.1111/ejn.12208
dc.identifier.eissnpl
1460-9568
dc.identifier.issnpl
0953-816X
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/5763
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
bez licencji
dc.rights.uri*
dc.subject.enpl
AMPA receptors
dc.subject.enpl
Ca^{2+}/calmodulin-dependent protein kinase II
dc.subject.enpl
long-term
dc.subject.enpl
potentiation
dc.subject.enpl
maternal separation
dc.subject.enpl
postsynaptic density protein 95
dc.subtypepl
Article
dc.titlepl
Early-life stress affects the structural and functional plasticity of the medial prefrontal cortex in adolescent rats
dc.title.journalpl
European Journal of Neuroscience
dc.typepl
JournalArticle
dspace.entity.type
Publication
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