The proliferative response of S-100 protein-positive glial cells to injury in the neonatal rat brain

1991
journal article
article
34
dc.abstract.otherAstroglial proliferative response to unilateral injury of the cerebral hemisphere was studied in newborn rats using [H-3]thymidine autoradiography combined with immunocytochemical staining for S-100 protein as an astroglial marker. The animals received [H-3]thymidine at different intervals following injury and the distribution of double-labeled cells was recorded 4 h after each [H-3]thymidine injection. The reactive proliferation of all cells within the investigated areas was detectable as early as about 2 h after injury. However, the quantitative increase in astroglial mitotic rate could be first detected on day 1 following the injury and the reactive changes were observed until day 8. They were regarded as evidence for the ability of astroglia to proliferate in response to injury in the neonatal brain. Since the astroglial divisions occurred mainly at the lesion site, the post-traumatic gliosis could be considered not only a result of astrocyte migration towards the lesion but also an effect of local mitotic activity.pl
dc.affiliationWydział Biologii i Nauk o Ziemi : Instytut Zoologiipl
dc.contributor.authorJaneczko, Krzysztof - 128444 pl
dc.date.accessioned2015-03-12T09:38:07Z
dc.date.available2015-03-12T09:38:07Z
dc.date.issued1991pl
dc.description.number1pl
dc.description.physical86-90pl
dc.description.volume564pl
dc.identifier.doi10.1016/0006-8993(91)91355-5pl
dc.identifier.eissn1872-6240pl
dc.identifier.issn0006-8993pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/3765
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.uri*
dc.subject.enbrain injurypl
dc.subject.enreactive astrocyte proliferationpl
dc.subject.ennewborn ratpl
dc.subject.enS-100 protein immunocytochemistrypl
dc.subject.enautoradiographypl
dc.subtypeArticlepl
dc.titleThe proliferative response of S-100 protein-positive glial cells to injury in the neonatal rat brainpl
dc.title.journalBrain Researchpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.otherpl
Astroglial proliferative response to unilateral injury of the cerebral hemisphere was studied in newborn rats using [H-3]thymidine autoradiography combined with immunocytochemical staining for S-100 protein as an astroglial marker. The animals received [H-3]thymidine at different intervals following injury and the distribution of double-labeled cells was recorded 4 h after each [H-3]thymidine injection. The reactive proliferation of all cells within the investigated areas was detectable as early as about 2 h after injury. However, the quantitative increase in astroglial mitotic rate could be first detected on day 1 following the injury and the reactive changes were observed until day 8. They were regarded as evidence for the ability of astroglia to proliferate in response to injury in the neonatal brain. Since the astroglial divisions occurred mainly at the lesion site, the post-traumatic gliosis could be considered not only a result of astrocyte migration towards the lesion but also an effect of local mitotic activity.
dc.affiliationpl
Wydział Biologii i Nauk o Ziemi : Instytut Zoologii
dc.contributor.authorpl
Janeczko, Krzysztof - 128444
dc.date.accessioned
2015-03-12T09:38:07Z
dc.date.available
2015-03-12T09:38:07Z
dc.date.issuedpl
1991
dc.description.numberpl
1
dc.description.physicalpl
86-90
dc.description.volumepl
564
dc.identifier.doipl
10.1016/0006-8993(91)91355-5
dc.identifier.eissnpl
1872-6240
dc.identifier.issnpl
0006-8993
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/3765
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.uri*
dc.subject.enpl
brain injury
dc.subject.enpl
reactive astrocyte proliferation
dc.subject.enpl
newborn rat
dc.subject.enpl
S-100 protein immunocytochemistry
dc.subject.enpl
autoradiography
dc.subtypepl
Article
dc.titlepl
The proliferative response of S-100 protein-positive glial cells to injury in the neonatal rat brain
dc.title.journalpl
Brain Research
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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