Respiration phase-locks to fast stimulus presentations : implications for the interpretation of posterior midline "deactivations"

2014
journal article
article
33
dc.abstract.enThe posterior midline region (PMR)-considered a core of the default mode network-is deactivated during successful performance in different cognitive tasks. The extent of PMR-deactivations is correlated with task-demands and associated with successful performance in various cognitive domains. In the domain of episodic memory, functional MRI (fMRI) studies found that PMR-deactivations reliably predict learning (successful encoding). Yet it is unclear what explains this relation. One intriguing possibility is that PMR-deactivations are partially mediated by respiratory artifacts. There is evidence that the fMRI signal in PMR is particularly prone to respiratory artifacts, because of its large surrounding blood vessels. As respiratory fluctuations have been shown to track changes in attention, it is critical for the general interpretation of fMRI results to clarify the relation between respiratory fluctuations, cognitive performance, and fMRI signal. Here, we investigated this issue by measuring respiration during word encoding, together with a breath-holding condition during fMRI-scanning. Stimulus-locked respiratory analyses showed that respiratory fluctuations predicted successful encoding via a respiratory phase-locking mechanism. At the same time, the fMRI analyses showed that PMR-deactivations associated with learning were reduced during breath-holding and correlated with individual differences in the respiratory phase-locking effect during normal breathing. A left frontal region-used as a control region-did not show these effects. These findings indicate that respiration is a critical factor in explaining the link between PMR-deactivation and successful cognitive performance. Further research is necessary to demonstrate whether our findings are restricted to episodic memory encoding, or also extend to other cognitive domains.pl
dc.affiliationPion Prorektora ds. badań naukowych i funduszy strukturalnych : Małopolskie Centrum Biotechnologiipl
dc.contributor.authorHuijbers, Willempl
dc.contributor.authorPennartz, Cyriel M. A.pl
dc.contributor.authorBeldzik, Ewa - 145217 pl
dc.contributor.authorDomagalik-Pittner, Aleksandra - 135778 pl
dc.contributor.authorVinck, M.pl
dc.contributor.authorHofman, Winnie F.pl
dc.contributor.authorCabeza, Robertopl
dc.contributor.authorDaselaar, Sander M.pl
dc.date.accessioned2017-02-07T15:11:40Z
dc.date.available2017-02-07T15:11:40Z
dc.date.issued2014pl
dc.description.number9pl
dc.description.physical4932-4943pl
dc.description.volume35pl
dc.identifier.doi10.1002/hbm.22523pl
dc.identifier.eissn1097-0193pl
dc.identifier.issn1065-9471pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/37218
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licencebez licencji
dc.rights.uri*
dc.subtypeArticlepl
dc.titleRespiration phase-locks to fast stimulus presentations : implications for the interpretation of posterior midline "deactivations"pl
dc.title.journalHuman Brain Mappingpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
The posterior midline region (PMR)-considered a core of the default mode network-is deactivated during successful performance in different cognitive tasks. The extent of PMR-deactivations is correlated with task-demands and associated with successful performance in various cognitive domains. In the domain of episodic memory, functional MRI (fMRI) studies found that PMR-deactivations reliably predict learning (successful encoding). Yet it is unclear what explains this relation. One intriguing possibility is that PMR-deactivations are partially mediated by respiratory artifacts. There is evidence that the fMRI signal in PMR is particularly prone to respiratory artifacts, because of its large surrounding blood vessels. As respiratory fluctuations have been shown to track changes in attention, it is critical for the general interpretation of fMRI results to clarify the relation between respiratory fluctuations, cognitive performance, and fMRI signal. Here, we investigated this issue by measuring respiration during word encoding, together with a breath-holding condition during fMRI-scanning. Stimulus-locked respiratory analyses showed that respiratory fluctuations predicted successful encoding via a respiratory phase-locking mechanism. At the same time, the fMRI analyses showed that PMR-deactivations associated with learning were reduced during breath-holding and correlated with individual differences in the respiratory phase-locking effect during normal breathing. A left frontal region-used as a control region-did not show these effects. These findings indicate that respiration is a critical factor in explaining the link between PMR-deactivation and successful cognitive performance. Further research is necessary to demonstrate whether our findings are restricted to episodic memory encoding, or also extend to other cognitive domains.
dc.affiliationpl
Pion Prorektora ds. badań naukowych i funduszy strukturalnych : Małopolskie Centrum Biotechnologii
dc.contributor.authorpl
Huijbers, Willem
dc.contributor.authorpl
Pennartz, Cyriel M. A.
dc.contributor.authorpl
Beldzik, Ewa - 145217
dc.contributor.authorpl
Domagalik-Pittner, Aleksandra - 135778
dc.contributor.authorpl
Vinck, M.
dc.contributor.authorpl
Hofman, Winnie F.
dc.contributor.authorpl
Cabeza, Roberto
dc.contributor.authorpl
Daselaar, Sander M.
dc.date.accessioned
2017-02-07T15:11:40Z
dc.date.available
2017-02-07T15:11:40Z
dc.date.issuedpl
2014
dc.description.numberpl
9
dc.description.physicalpl
4932-4943
dc.description.volumepl
35
dc.identifier.doipl
10.1002/hbm.22523
dc.identifier.eissnpl
1097-0193
dc.identifier.issnpl
1065-9471
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/37218
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
bez licencji
dc.rights.uri*
dc.subtypepl
Article
dc.titlepl
Respiration phase-locks to fast stimulus presentations : implications for the interpretation of posterior midline "deactivations"
dc.title.journalpl
Human Brain Mapping
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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