IgA antiphospholipid antibodies and anti-domain 1 of beta 2 glycoprotein 1 antibodies are associated with livedo reticularis and heart valve disease in antiphospholipid syndrome

2014
journal article
article
dc.abstract.enBackground. Antiphospholipid syndrome (APS) is an autoimmune disease associated with venous or arterial thrombosis and pregnancy loss, but also infrequently with non-criteria APS manifestations such as thrombocytopenia, livedo reticularis and heart valve disease. The occurrence of antiphospholipid antibodies is necessary to diagnose APS and includes the presence of lupus anticoagulant and anticardiolipin as well as anti-β2-glycoprotein I antibodies, both in IgM and/or IgG isotype. Objectives. The aim of this study was to evaluate the associations between antiphospholipid antibodies including IgA isotype and IgG anti-domain I of β2-glycoprotein I (β-2GPI-D1) and non-criteria-related manifestations of APS. Material and Methods. Thirty-three consecutive APS patients (26 women, 7 men, aged 44.1 ± 15 years), including 23 (69.7%) subjects with primary APS, were enrolled. Together with standard antiphospholipid antibodies, IgA anticardiolipin, IgA anti-β2-glycoprotein I and IgG anti-β-2GPI-D1 antibodies in serum samples were evaluated by chemiluminescence using the QUANTA Flash® System. Results. Livedo reticularis (n = 8, 24.2%) was associated with increased levels of IgG anti-β-2GPI-D1 (p = 0.005), IgA anticardiolipin (p = 0.001) and IgA anti-β2-glycoprotein I (p = 0.002) antibodies. Heart valve disease (n = 9, 27.3%) was observed in patients with higher IgG anti-β-2GPI-D1 (p = 0.01). The associations of HVD with increased levels of IgA aCL and IgA anti-β-2GPI tended to be significant (p = 0.07). None of antiphospholipid antibodies showed association with thrombocytopenia (n = 6, 18.2%). Conclusions. Our study suggests that increased IgA antiphospholipid antibodies and IgG anti-β-2GPI-D1 antibodies may be involved in the development of livedo reticularis and heart valve disease in APS patients.pl
dc.affiliationWydział Lekarski : Instytut Kardiologiipl
dc.contributor.authorCieśla, Marekpl
dc.contributor.authorWypasek, Ewa - 132801 pl
dc.contributor.authorUndas, Anetta - 133708 pl
dc.date.accession2020-12-08pl
dc.date.accessioned2015-02-27T09:56:06Z
dc.date.available2015-02-27T09:56:06Z
dc.date.created2014pl
dc.date.issued2014pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number5pl
dc.description.physical729–733pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume23pl
dc.identifier.eissn1899–5276pl
dc.identifier.issn1230-025Xpl
dc.identifier.projectROD UJ / Ppl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/3371
dc.identifier.weblinkhttp://www.advances.umed.wroc.pl/en/article/2014/23/5/729/pl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 3.0 Polska*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/legalcode*
dc.share.typeotwarte czasopismo
dc.subject.enantiphospholipid syndromepl
dc.subject.enbeta 2 glycoprotein 1pl
dc.subject.endomain 1pl
dc.subject.enheart valve diseasepl
dc.subject.enlivedo reticularispl
dc.subtypeArticlepl
dc.titleIgA antiphospholipid antibodies and anti-domain 1 of beta 2 glycoprotein 1 antibodies are associated with livedo reticularis and heart valve disease in antiphospholipid syndromepl
dc.title.journalAdvances in Clinical and Experimental Medicinepl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Background. Antiphospholipid syndrome (APS) is an autoimmune disease associated with venous or arterial thrombosis and pregnancy loss, but also infrequently with non-criteria APS manifestations such as thrombocytopenia, livedo reticularis and heart valve disease. The occurrence of antiphospholipid antibodies is necessary to diagnose APS and includes the presence of lupus anticoagulant and anticardiolipin as well as anti-β2-glycoprotein I antibodies, both in IgM and/or IgG isotype. Objectives. The aim of this study was to evaluate the associations between antiphospholipid antibodies including IgA isotype and IgG anti-domain I of β2-glycoprotein I (β-2GPI-D1) and non-criteria-related manifestations of APS. Material and Methods. Thirty-three consecutive APS patients (26 women, 7 men, aged 44.1 ± 15 years), including 23 (69.7%) subjects with primary APS, were enrolled. Together with standard antiphospholipid antibodies, IgA anticardiolipin, IgA anti-β2-glycoprotein I and IgG anti-β-2GPI-D1 antibodies in serum samples were evaluated by chemiluminescence using the QUANTA Flash® System. Results. Livedo reticularis (n = 8, 24.2%) was associated with increased levels of IgG anti-β-2GPI-D1 (p = 0.005), IgA anticardiolipin (p = 0.001) and IgA anti-β2-glycoprotein I (p = 0.002) antibodies. Heart valve disease (n = 9, 27.3%) was observed in patients with higher IgG anti-β-2GPI-D1 (p = 0.01). The associations of HVD with increased levels of IgA aCL and IgA anti-β-2GPI tended to be significant (p = 0.07). None of antiphospholipid antibodies showed association with thrombocytopenia (n = 6, 18.2%). Conclusions. Our study suggests that increased IgA antiphospholipid antibodies and IgG anti-β-2GPI-D1 antibodies may be involved in the development of livedo reticularis and heart valve disease in APS patients.
dc.affiliationpl
Wydział Lekarski : Instytut Kardiologii
dc.contributor.authorpl
Cieśla, Marek
dc.contributor.authorpl
Wypasek, Ewa - 132801
dc.contributor.authorpl
Undas, Anetta - 133708
dc.date.accessionpl
2020-12-08
dc.date.accessioned
2015-02-27T09:56:06Z
dc.date.available
2015-02-27T09:56:06Z
dc.date.createdpl
2014
dc.date.issuedpl
2014
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
5
dc.description.physicalpl
729–733
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
23
dc.identifier.eissnpl
1899–5276
dc.identifier.issnpl
1230-025X
dc.identifier.projectpl
ROD UJ / P
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/3371
dc.identifier.weblinkpl
http://www.advances.umed.wroc.pl/en/article/2014/23/5/729/
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 3.0 Polska
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/3.0/legalcode
dc.share.type
otwarte czasopismo
dc.subject.enpl
antiphospholipid syndrome
dc.subject.enpl
beta 2 glycoprotein 1
dc.subject.enpl
domain 1
dc.subject.enpl
heart valve disease
dc.subject.enpl
livedo reticularis
dc.subtypepl
Article
dc.titlepl
IgA antiphospholipid antibodies and anti-domain 1 of beta 2 glycoprotein 1 antibodies are associated with livedo reticularis and heart valve disease in antiphospholipid syndrome
dc.title.journalpl
Advances in Clinical and Experimental Medicine
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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