Ophthalmic applicator displacement as a method of treating large diffuse uveal melanomas

2023
journal article
article
1
dc.abstract.enPurpose: The presentation of results of an ophthalmic plaque displacement as a brachytherapy treatment method of large diffuse uveal melanomas. Material and methods: This was a retrospective analysis of treatment results of 9 patients with large diffuse uveal melanomas using ophthalmic plaque displacement. Patients were treated with this method in our center between 2012 and 2021 (last follow-up visit in 2023). To achieve appropriate radiation dose distribution for large tumors with a base greater than 18 mm, brachytherapy ($^{106}$Ru in 7 patients and $^{125}$I in 2 patients) with applicator displacement was used as primary treatment. Median follow-up was 2.9 years, and for patients with positive primary treatment results, it was 1.7 months. Median time to local relapse was 2.3 years. Results: In 5 patients, a positive result of local treatment was obtained, out of whom, one patient underwent enucleation due to complications. In the next 4 cases, local recurrence developed. In all tumors, the use of applicator displacement method caused that planning target volume (PTV) was effectively covered with treatment isodose. Conclusions: Brachytherapy with ocular applicator displacement allows for the treatment of tumors with base measurements larger than 18 mm. The application of this method may be considered as an alternative for eye enucleation in particular cases of large diffuse tumors, such as a neoplasm of the eye with vison, or when a patient does not consent to enucleation.pl
dc.affiliationWydział Lekarski : Klinika Okulistyki i Onkologii Okulistycznejpl
dc.affiliationWydział Lekarski : Zakład Biofizykipl
dc.affiliationWydział Fizyki, Astronomii i Informatyki Stosowanejpl
dc.cm.id112820pl
dc.cm.idOmegaUJCM2b7c028c6c334331ac8b0c5d25c19fabpl
dc.contributor.authorMarkiewicz, Anna - 130866 pl
dc.contributor.authorSkórkiewicz, Konrad - 188612 pl
dc.contributor.authorBogdał, Agata - 209580 pl
dc.contributor.authorMedoń, Dominikpl
dc.contributor.authorŚwider, Mirellapl
dc.contributor.authorKorab-Chrzanowska, Elżbietapl
dc.contributor.authorKowal, Joanna - 364512 pl
dc.contributor.authorDębicka-Kumela, Magdalena - 355444 pl
dc.contributor.authorRomanowska-Dixon, Bożena - 133294 pl
dc.date.accession2023-07-27pl
dc.date.accessioned2023-08-23T12:33:38Z
dc.date.available2023-08-23T12:33:38Z
dc.date.issued2023pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number3pl
dc.description.physical184-190pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume15pl
dc.identifier.doi10.5114/jcb.2023.128920pl
dc.identifier.eissn2081-2841pl
dc.identifier.issn1689-832Xpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/317894
dc.identifier.weblinkhttps://www.termedia.pl/Ophthalmic-applicator-displacement-as-a-method-of-treating-large-diffuse-uveal-melanomas,54,50907,1,1.htmlpl
dc.languageengpl
dc.language.containerengpl
dc.pbn.affiliationDziedzina nauk medycznych i nauk o zdrowiu : nauki medycznepl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-SA
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl*
dc.share.typeOtwarte czasopismo
dc.subject.enuveal melanomapl
dc.subject.enapplicator displacementpl
dc.subject.enplaque displacementpl
dc.subject.enbrachytherapypl
dc.subject.enenucleationpl
dc.subject.enocular melanomapl
dc.subject.endiffuse uveal melanomapl
dc.subject.enophthalmic applicatorpl
dc.subtypeArticlepl
dc.titleOphthalmic applicator displacement as a method of treating large diffuse uveal melanomaspl
dc.title.journalJournal of Contemporary Brachytherapypl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Purpose: The presentation of results of an ophthalmic plaque displacement as a brachytherapy treatment method of large diffuse uveal melanomas. Material and methods: This was a retrospective analysis of treatment results of 9 patients with large diffuse uveal melanomas using ophthalmic plaque displacement. Patients were treated with this method in our center between 2012 and 2021 (last follow-up visit in 2023). To achieve appropriate radiation dose distribution for large tumors with a base greater than 18 mm, brachytherapy ($^{106}$Ru in 7 patients and $^{125}$I in 2 patients) with applicator displacement was used as primary treatment. Median follow-up was 2.9 years, and for patients with positive primary treatment results, it was 1.7 months. Median time to local relapse was 2.3 years. Results: In 5 patients, a positive result of local treatment was obtained, out of whom, one patient underwent enucleation due to complications. In the next 4 cases, local recurrence developed. In all tumors, the use of applicator displacement method caused that planning target volume (PTV) was effectively covered with treatment isodose. Conclusions: Brachytherapy with ocular applicator displacement allows for the treatment of tumors with base measurements larger than 18 mm. The application of this method may be considered as an alternative for eye enucleation in particular cases of large diffuse tumors, such as a neoplasm of the eye with vison, or when a patient does not consent to enucleation.
dc.affiliationpl
Wydział Lekarski : Klinika Okulistyki i Onkologii Okulistycznej
dc.affiliationpl
Wydział Lekarski : Zakład Biofizyki
dc.affiliationpl
Wydział Fizyki, Astronomii i Informatyki Stosowanej
dc.cm.idpl
112820
dc.cm.idOmegapl
UJCM2b7c028c6c334331ac8b0c5d25c19fab
dc.contributor.authorpl
Markiewicz, Anna - 130866
dc.contributor.authorpl
Skórkiewicz, Konrad - 188612
dc.contributor.authorpl
Bogdał, Agata - 209580
dc.contributor.authorpl
Medoń, Dominik
dc.contributor.authorpl
Świder, Mirella
dc.contributor.authorpl
Korab-Chrzanowska, Elżbieta
dc.contributor.authorpl
Kowal, Joanna - 364512
dc.contributor.authorpl
Dębicka-Kumela, Magdalena - 355444
dc.contributor.authorpl
Romanowska-Dixon, Bożena - 133294
dc.date.accessionpl
2023-07-27
dc.date.accessioned
2023-08-23T12:33:38Z
dc.date.available
2023-08-23T12:33:38Z
dc.date.issuedpl
2023
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
3
dc.description.physicalpl
184-190
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
15
dc.identifier.doipl
10.5114/jcb.2023.128920
dc.identifier.eissnpl
2081-2841
dc.identifier.issnpl
1689-832X
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/317894
dc.identifier.weblinkpl
https://www.termedia.pl/Ophthalmic-applicator-displacement-as-a-method-of-treating-large-diffuse-uveal-melanomas,54,50907,1,1.html
dc.languagepl
eng
dc.language.containerpl
eng
dc.pbn.affiliationpl
Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-SA
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
Otwarte czasopismo
dc.subject.enpl
uveal melanoma
dc.subject.enpl
applicator displacement
dc.subject.enpl
plaque displacement
dc.subject.enpl
brachytherapy
dc.subject.enpl
enucleation
dc.subject.enpl
ocular melanoma
dc.subject.enpl
diffuse uveal melanoma
dc.subject.enpl
ophthalmic applicator
dc.subtypepl
Article
dc.titlepl
Ophthalmic applicator displacement as a method of treating large diffuse uveal melanomas
dc.title.journalpl
Journal of Contemporary Brachytherapy
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.

Views
2
Views per month
Views per city
Krakow
2