Synaptic plasticity, astrocytes and morphological homeostasis

2006
journal article
article
40
dc.abstract.otherRecent discoveries suggest that astrocytes are an integral part of synaptic connections, as they sense and modulate synaptic activity. Moreover, there is evidence that astrocytes change the number of synaptic connections directly via synaptogenic signals or indirectly, by modifying the morphology of axons and dendrites. Here, we formulate the hypothesis that astrocytes mediate the morphological homeostasis of nerve cells, which is any adaptation of the morphology of a neuron to preserve its ability to respond to and generate synaptic activity during learning and mernory-induced changes. We argue that astrocytes control neuronal morphology locally and across long-ranging assemblies of neurons and that on the other hand, astrocytes, are part of the engram with plasticity-related changes affecting their morphology.pl
dc.affiliationWydział Biologii i Nauk o Ziemi : Instytut Zoologiipl
dc.contributor.authorŚlęzak, Michał - 143670 pl
dc.contributor.authorPfrieger, Frank W.pl
dc.contributor.authorSołtys, Zbigniew - 147734 pl
dc.date.accessioned2016-09-28T10:47:48Z
dc.date.available2016-09-28T10:47:48Z
dc.date.issued2006pl
dc.description.number2-3pl
dc.description.physical84-91pl
dc.description.volume99pl
dc.identifier.doi10.1016/j.jphysparis.2005.12.082pl
dc.identifier.eissn1769-7115pl
dc.identifier.issn0928-4257pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/30922
dc.languageengpl
dc.language.containerengpl
dc.rights.licencebez licencji
dc.subtypeArticlepl
dc.titleSynaptic plasticity, astrocytes and morphological homeostasispl
dc.title.journalJournal of Physiology. Parispl
dc.title.volumeThe World of the Synapse : Molecular Basis, Pathologies and Drug Discoverypl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.otherpl
Recent discoveries suggest that astrocytes are an integral part of synaptic connections, as they sense and modulate synaptic activity. Moreover, there is evidence that astrocytes change the number of synaptic connections directly via synaptogenic signals or indirectly, by modifying the morphology of axons and dendrites. Here, we formulate the hypothesis that astrocytes mediate the morphological homeostasis of nerve cells, which is any adaptation of the morphology of a neuron to preserve its ability to respond to and generate synaptic activity during learning and mernory-induced changes. We argue that astrocytes control neuronal morphology locally and across long-ranging assemblies of neurons and that on the other hand, astrocytes, are part of the engram with plasticity-related changes affecting their morphology.
dc.affiliationpl
Wydział Biologii i Nauk o Ziemi : Instytut Zoologii
dc.contributor.authorpl
Ślęzak, Michał - 143670
dc.contributor.authorpl
Pfrieger, Frank W.
dc.contributor.authorpl
Sołtys, Zbigniew - 147734
dc.date.accessioned
2016-09-28T10:47:48Z
dc.date.available
2016-09-28T10:47:48Z
dc.date.issuedpl
2006
dc.description.numberpl
2-3
dc.description.physicalpl
84-91
dc.description.volumepl
99
dc.identifier.doipl
10.1016/j.jphysparis.2005.12.082
dc.identifier.eissnpl
1769-7115
dc.identifier.issnpl
0928-4257
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/30922
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights.licence
bez licencji
dc.subtypepl
Article
dc.titlepl
Synaptic plasticity, astrocytes and morphological homeostasis
dc.title.journalpl
Journal of Physiology. Paris
dc.title.volumepl
The World of the Synapse : Molecular Basis, Pathologies and Drug Discovery
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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